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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 810 - 821
We found serum lipid profiles changed in women with PCOS. Obesity and compensatory hyperinsulinemia promoted the metabolism of arachidonic acid and other PUFAs, whereas androgen had an inhibitory effect. Abstract Context... 
POLYCYSTIC-OVARY-SYNDROME | IONIZATION-MASS-SPECTROMETRY | RISK-FACTORS | TESTOSTERONE | BIOLOGICAL SAMPLES | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | NONALCOHOLIC STEATOHEPATITIS | FAT-CELL LIPOLYSIS | OLDER CHINESE | OBESE WOMEN | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Linoleic Acid - metabolism | Humans | Dehydroepiandrosterone Sulfate - metabolism | Case-Control Studies | Young Adult | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Diet, High-Fat | Mass Spectrometry | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Fatty Acids - metabolism | Phosphatidylglycerols - metabolism | Disease Models, Animal | Hyperinsulinism - metabolism | Ceramides - metabolism | Hyperinsulinism - complications | Polycystic Ovary Syndrome - metabolism | Cholesterol, HDL - metabolism | Obesity - complications | Eicosapentaenoic Acid - metabolism | Rats | Sex Hormone-Binding Globulin - metabolism | Lipid Metabolism | Fatty Acids, Unsaturated - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Triglycerides - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Animals | Cholesterol, LDL - metabolism | Phosphatidic Acids - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Docosahexaenoic Acids - metabolism | Polycystic ovary syndrome | Obesity | Hyperinsulinemia | Lecithin | Polyunsaturated fatty acids | Lipids | Mass spectroscopy | Liquid chromatography | Phospholipids | Metabolism | Arachidonic acid | Insulin | Fatty acids | Patients | Chromatography | Biological activity | Subgroups | Gas chromatography | Androgens | Molecular modelling | Metabolites | Lipid metabolism | Mass spectrometry | Metabolic disorders
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2012, Volume 109, Issue 22, pp. 8517 - 8522
Dietary fish oil containing ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA... 
Prostaglandins | Receptors | Cellular metabolism | Cyclooxygenase inhibitors | Eicosanoids | Lipids | Phospholipids | Cell membranes | Lipid metabolism | Fatty acids | P388D MACROPHAGES | CYTOSOLIC PHOSPHOLIPASE A | INHIBITION | RAW264.7 CELLS | PROSTAGLANDIN-E SYNTHASE-1 | MULTIDISCIPLINARY SCIENCES | PURIFICATION | N-3 FATTY-ACIDS | CELL-PROLIFERATION | EXPRESSION | ARACHIDONATE | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Male | Macrophages, Peritoneal - cytology | Adenosine Triphosphate - pharmacology | Lipoxygenase - metabolism | Fatty Acids, Omega-3 - pharmacology | Toll-Like Receptor 4 - agonists | Cell Membrane - metabolism | Macrophages, Peritoneal - drug effects | Cell Membrane - drug effects | Cell Line | Fatty Acids, Omega-3 - metabolism | Cells, Cultured | Fatty Acids, Unsaturated - pharmacology | Phospholipases A2 - metabolism | Fatty Acids, Unsaturated - metabolism | Macrophages - cytology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Docosahexaenoic Acids - pharmacology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Prostaglandin-Endoperoxide Synthases - metabolism | Eicosanoids - metabolism | Arachidonic Acid - pharmacology | Lipopolysaccharides - pharmacology | Membrane Lipids - metabolism | Receptors, Purinergic P2X7 - metabolism | Macrophages - drug effects | Mice | Macrophages, Peritoneal - metabolism | Docosahexaenoic Acids - metabolism | Physiological aspects | Eicosanoic acid | Research | Health aspects | Omega-3 fatty acids | Proteomics | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e112945
...), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 2014, Volume 1842, Issue 7, pp. 959 - 970
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 31, pp. 25758 - 25769
... and primarily requires fatty acid oxidation for energy. We reported previously that switching from the early to the late acute inflammatory response following TLR4 stimulation depends on NAD... 
MACROPHAGE-MEDIATED INFLAMMATION | HOMEOSTASIS | T-CELL MEMORY | METABOLISM | ADIPONECTIN | INSULIN-RESISTANCE | IMMUNOSUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN TOLERANCE | SEPSIS | DIFFERENTIATION | Sirtuin 1 - metabolism | Humans | Monocyte-Macrophage Precursor Cells - immunology | Glucose Transporter Type 1 - metabolism | Monocyte-Macrophage Precursor Cells - metabolism | Leukocytes - immunology | Heat-Shock Proteins - genetics | Monocyte-Macrophage Precursor Cells - physiology | Nicotinamide Phosphoribosyltransferase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sepsis - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NAD - biosynthesis | Fatty Acids - metabolism | Cell Line | Sepsis - immunology | Cytokines - metabolism | Oxidation-Reduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Adaptation, Physiological - immunology | Animals | Carrier Proteins - metabolism | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Glycolysis | Mice | Leukocytes - metabolism | Sirtuins - metabolism | NAD | Sirtuins | Immunology | Acute Inflammation | Bioenergetics | PGC-1 | Sepsis | HIF-1α | Biosensors | Macrophages | Metabolism
Journal Article
by Zhao, S and Xu, W and Jiang, W and Yu, W and Lin, Y and Zhang, T and Yao, J and Zhou, L and Zeng, Y and Li, H and Li, Y and Shi, J and An, W and Hancock, S. M and He, F and Qin, L and Chin, J and Yang, P and Chen, X and Lei, Q and Xiong, Y and Guan, K.-L
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 327, Issue 5968, pp. 1000 - 1004
.... Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue... 
Enzymes | Protein metabolism | Cellular metabolism | HEK293 cells | Amino acids | Reports | Acetylation | Physiological regulation | Lipid metabolism | Liver cells | Fatty acids | PHOSPHOENOLPYRUVATE CARBOXYKINASE | GLUCONEOGENESIS | MULTIDISCIPLINARY SCIENCES | DEFICIENCY | Liver - enzymology | Humans | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Multienzyme Complexes - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Argininosuccinate Lyase - metabolism | Glycogen - metabolism | Urea - metabolism | Lysine - metabolism | Fatty Acids - metabolism | Enzymes - metabolism | Gluconeogenesis | Malate Dehydrogenase - metabolism | Cell Line | Argininosuccinate Lyase - genetics | Oxidation-Reduction | Enoyl-CoA Hydratase - metabolism | Liver - metabolism | Proteome | Citric Acid Cycle | Proteins - metabolism | Peroxisomal Bifunctional Enzyme | Glycolysis | Protein Processing, Post-Translational | Isomerases - metabolism | Hepatocytes - enzymology | Post-translational modification | Cellular proteins | Lysine | Cellular control mechanisms | Cell metabolism | Physiological aspects | Research | Chemical properties | Proteins | Biochemistry | Cellular biology | Metabolism
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 551, Issue 7678, pp. 115 - 118
Journal Article
The Plant cell, ISSN 1040-4651, 11/2010, Volume 22, Issue 11, pp. 3845 - 3863
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and nutrients (e.g., amino acids... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article