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RNA, ISSN 1355-8382, 10/2013, Volume 19, Issue 10, pp. 1449 - 1459
Here we demonstrate the use of strong anion-exchange fast performance liquid chromatography (FPLC) as a simple, fast, and robust method for RNA production by... 
Aminoacylation
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 05/2011, Volume 108, Issue 20, pp. 8239 - 8244
Human lysyl-tRNA synthetase is bound to the multi-tRNA synthetase complex (MSC) that maintains and regulates the aminoacylation and nuclear functions of LysRS.... 
Aminoacylation
Journal Article
11/2012
Methods are being developed to produce “designer proteins” from unnatural amino acids that are added into specific locations by the ribosome using an altered... 
tRNA | aminoacylation | 0490
Dissertation
11/2009
Direct synthesis of aminoacyl-tRNA occurs using α-N-tBoc-protected aminoacyl phosphates and lanthanum salts. Deprotection of aminoacyl tRNA is essential prior... 
tRNA | 0487 | aminoacylation
Dissertation
11/2009
Synthesizing proteins containing unnatural amino acids inserted at specific positions within the protein sequence has been a longstanding goal of biological... 
Aminoacylation | Bioorganic | Lanthanum | 0490
Dissertation
RNA Biology, ISSN 1547-6286, 05/2018, Volume 15, Issue 4-5, pp. 667 - 677
Inhibition of tRNA aminoacylation has proven to be an effective antimicrobial strategy, impeding an essential step of protein synthesis. Mupirocin, the... 
Aminoacylation | transfer RNA | translation inhibitors | drug development | drug targets | antibiotic targets | antimicrobials | aminoacyl tRNA synthetases | antibiotics | ACCEPTOR IN-VITRO | DISCRIMINATOR BASE | RIBONUCLEASE-P RIBOZYME | IDENTITY DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHETASE INHIBITORS | GENETIC-CODE | CONFORMATIONAL-CHANGES | PROTEIN-PROTEIN INTERACTIONS | SPECIES-SPECIFIC AMINOACYLATION | THERMUS-THERMOPHILUS | Thermus thermophilus - drug effects | Protein Synthesis Inhibitors - chemistry | Species Specificity | Escherichia coli - drug effects | Humans | Structure-Activity Relationship | Fatty Alcohols - chemistry | Fatty Alcohols - pharmacology | Thermus thermophilus - genetics | RNA, Transfer, Leu - metabolism | Isoleucine-tRNA Ligase - genetics | Piperidines - pharmacology | Anti-Bacterial Agents - chemistry | Protein Synthesis Inhibitors - pharmacology | Quinazolinones - pharmacology | RNA, Transfer, Leu - genetics | Thermus thermophilus - enzymology | Piperidines - chemistry | Escherichia coli - enzymology | Transfer RNA Aminoacylation - genetics | Mupirocin - pharmacology | Mupirocin - chemistry | Isoleucine-tRNA Ligase - metabolism | Escherichia coli - genetics | RNA, Transfer, Leu - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Quinazolinones - chemistry | Transfer RNA Aminoacylation - drug effects | Isoleucine-tRNA Ligase - antagonists & inhibitors | Biochemistry & Molecular Biology
Journal Article
RNA, ISSN 1355-8382, 07/2001, Volume 7, Issue 7, pp. 1043 - 1051
We previously reported a bifunctional ribozyme that catalyzes self-aminoacylation and subsequent acyl-transfer to a tRNA. The ribozyme selectively recognizes a... 
aminoacylation
Journal Article
Journal Article
Human Mutation, ISSN 1059-7794, 10/2017, Volume 38, Issue 10, pp. 1348 - 1354
Aminoacyl‐transfer RNA (tRNA) synthetases ligate amino acids to specific tRNAs and are essential for protein synthesis. Although alanyl‐tRNA synthetase (AARS)... 
microcephaly | hypomyelination | transfer RNA | aminoacylation defect | AARS | MARIE-TOOTH-DISEASE | NEUROPATHY | AARS MUTATION | ATROPHY | GENETICS & HEREDITY | MEDICINE | BINDING | Spastic Paraplegia, Hereditary - genetics | Lennox Gastaut Syndrome - diagnosis | Microcephaly - genetics | Humans | Child, Preschool | Infant | Electroencephalography | Amino Acid Sequence - genetics | Spasms, Infantile - genetics | Aminoacylation - genetics | Lennox Gastaut Syndrome - genetics | Charcot-Marie-Tooth Disease - genetics | Alanine-tRNA Ligase - genetics | Microcephaly - pathology | Female | Protein Biosynthesis - genetics | Spasms, Infantile - complications | Spastic Paraplegia, Hereditary - pathology | Siblings | Microcephaly - diagnostic imaging | Spasms, Infantile - diagnostic imaging | Charcot-Marie-Tooth Disease - pathology | Mutation - genetics | Whole Exome Sequencing | Spasms, Infantile - pathology | Lennox Gastaut Syndrome - pathology | Spastic Paraplegia, Hereditary - complications | Lennox Gastaut Syndrome - complications | Medical research | Career development | Nervous system diseases | Neurosciences | Ligases | Encephalopathy | Epilepsy | Medicine, Experimental | Amino acids | Protein biosynthesis | Transfer RNA | Aminoacylation | tRNA | Spasticity | Microcephaly | Ribonucleic acid--RNA | Neurological diseases | Microencephaly | Alanine-tRNA ligase | Charcot-Marie-Tooth disease | Mutation
Journal Article
06/2008
Abstract “Biomimetic Aminoacylation” Svetlana K. Tzvetkova Doctor of Philosophy, 2008 Graduate Department of Chemistry University of Toronto The accuracy of... 
Aminoacylation tRNA | non-natural amino acids | 0490
Dissertation
Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7272, pp. 522 - 526
Journal Article
JOURNAL OF MOLECULAR EVOLUTION, ISSN 0022-2844, 04/2019, Volume 87, Issue 2-3, pp. 83 - 92
How ribosomal translation could have evolved remains an open question in most available scenarios for the early developments of life. Rather than considering... 
Translation | Aminoacylation | RNA | Phosphoramidate | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROLYSIS | POLYMERIZATION | STEREOSELECTIVE AMINOACYLATION | PEPTIDE FORMATION | EVOLUTIONARY BIOLOGY | ORIGIN | Amino acid | GENETICS & HEREDITY | Copolymer | TEMPLATE-DIRECTED SYNTHESIS | TRANSFER-RNA | ANHYDRIDES | OLIGOMERIZATION | PRECURSORS | Analysis | Polymerization | Amino acids | Nucleotides | Polymers | Genetic translation
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 11/2019, Volume 10, Issue 1, pp. 1 - 12
Journal Article
Nucleic acids research, ISSN 0305-1048, 08/2017, Volume 45, Issue 14, pp. e133 - e133
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2018, Volume 46, Issue 7, pp. 3643 - 3656
Journal Article
NATURE METHODS, ISSN 1548-7091, 05/2006, Volume 3, Issue 5, pp. 357 - 359
Here we describe a de novo tRNA acytation system, the flexizyme (Fx) system, for the preparation of acyl tRNAs with nearly unlimited selection of amino and... 
RIBOZYME | GENETIC-CODE | AMINO-ACIDS | BIOCHEMICAL RESEARCH METHODS | SITE-SPECIFIC INCORPORATION | AMINOACYLATION
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 01/2015, Volume 142, pp. 59 - 67
The ( ) leucyl-tRNA synthetase (LeuRS) enzyme is part of the aminoacyl-tRNA synthetase (aaRS) family. LeuRS is an essential enzyme that relies on specialized... 
Leucyl-tRNA synthetase | Aminoacylation reaction | ZN-1 domain
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2018, Volume 285, Issue 14, pp. 2654 - 2661
Journal Article
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