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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 2836 - 2845
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2017, Volume 259, pp. e68 - e68
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2012, Volume 379, Issue 9825, pp. 1508 - 1516
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 10, pp. e0206158 - e0206158
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are responsible for thousands of inherited diseases. Readthrough of... 
SYNTHETIC AMINOGLYCOSIDES | ZEBRAFISH | PTC124 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | HUMAN GENETIC-DISEASES | DESIGNER AMINOGLYCOSIDES | CYSTIC-FIBROSIS | SUPPRESSION | ATALUREN | NONSENSE MUTATION | Gentamicins - chemistry | Antibiotics, Antineoplastic - pharmacology | Gentamicins - therapeutic use | Kidney Diseases - pathology | Humans | Cells, Cultured | Codon, Terminator - chemical synthesis | Rats | Male | Open Reading Frames - genetics | Zebrafish - embryology | Rats, Sprague-Dawley | Animals | Gentamicins - pharmacology | Embryo, Nonmammalian | Kidney Diseases - chemically induced | Codon, Nonsense - chemical synthesis | Protein Synthesis Inhibitors - pharmacology | Aminoglycosides - pharmacology | Open Reading Frames - drug effects | Genetic Diseases, Inborn - drug therapy | Protein Synthesis Inhibitors - therapeutic use | Aminoglycosides - therapeutic use | Physiological aspects | Genetic aspects | Research | Gene mutations | Gentamicin | Aminoglycosides | Codon | Genetic translation | Health aspects | Disease | Nonsense mutation | Toxicity | Genes | Clinical trials | Cytotoxicity | Proteins | Insurance pools | Rodents | Translation termination | Aminoglycoside antibiotics | Biocompatibility | Safety | Genetic disorders | Stop codon | Cystic fibrosis | Pharmacology | Chemical compounds | Hereditary diseases | Reinsurance | Antibiotics | Mutation | Codons | Index Medicus
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1535-4989, 2014, Volume 50, Issue 4, pp. 805 - 816
New drugs are needed to enhance premature termination codon (PTC) suppression to treat the underlying cause of cystic fibrosis (CF) and other diseases caused... 
Aminoglycosides | Ivacaftor | Cystic fibrosis transmembrane conductance regulator | Nonsense mutations | Translational readthrough | ANTIBIOTICS | translational readthrough | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETIC-DISEASES | ivacaftor | GENTAMICIN | CELL BIOLOGY | IN-VITRO | PREMATURE STOP MUTATIONS | GLYCOSAMINOGLYCAN ACCUMULATION | RESPIRATORY SYSTEM | PTC124 TREATMENT | TERMINATION CODONS | cystic fibrosis transmembrane conductance regulator | nonsense mutations | aminoglycosides | DUCHENNE MUSCULAR-DYSTROPHY | CF MOUSE MODEL | Luciferases - metabolism | Aminophenols - pharmacokinetics | Humans | Rats, Inbred F344 | Quinolones - pharmacology | Aminophenols - pharmacology | Luciferases - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - drug effects | Transfection | Biological Transport | Time Factors | Quinolones - pharmacokinetics | Chlorides - metabolism | Organ of Corti - pathology | Genes, Reporter | Disease Models, Animal | Cell Line | Mice, Inbred CFTR | Aminoglycosides - pharmacokinetics | Cystic Fibrosis - metabolism | Codon, Nonsense - drug effects | Rats | Mice, Transgenic | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Drug Synergism | Animals | Aminoglycosides - toxicity | Cystic Fibrosis - genetics | Organ of Corti - drug effects | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aminoglycosides - pharmacology | Aminoglycosides - chemical synthesis | Cystic Fibrosis - drug therapy | Proteins | Studies | Cell culture | Genetic disorders | Antibiotics | Toxicity | Rodents | Cystic fibrosis | Mutation | Reproductive system | Muscular dystrophy | Original Research
Journal Article
Molecular systems biology, ISSN 1744-4292, 2013, Volume 9, Issue 1, pp. 700 - n/a
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast,... 
collateral sensitivity network | trade off | evolutionary experiment | antibiotic resistance | Antibiotic resistance | PERMEABILITY | ENTERICA SEROVAR TYPHIMURIUM | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SUSCEPTIBILITY | SALMONELLA | AMINOGLYCOSIDE | RESISTANCE | MULTIDRUG EFFLUX | STAPHYLOCOCCUS-AUREUS | Genome, Bacterial | Escherichia coli - drug effects | Selection, Genetic | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Resistance, Microbial - genetics | Biological Evolution | Microbial Sensitivity Tests | Aminoglycosides - metabolism | Biological Transport | Metabolic Networks and Pathways | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Membrane - metabolism | High-Throughput Nucleotide Sequencing | Mutation | Aminoglycosides - pharmacology | Cell Membrane - drug effects | Laboratories | Genes | Aminoglycosides | Genomes | Biosynthesis | Drug resistance | Experiments | Gene sequencing | Proteins | E coli | Evolution | Aminoglycoside antibiotics | Adaptation | Efflux | Integrated approach | Hypersensitivity | Antimicrobial agents | Acids | Antibiotics | Plasmids | Protein synthesis | Sensitivity enhancement | Transporter | Life Sciences | Medication | Pharmaceutical sciences
Journal Article
Toxicology Letters, ISSN 0378-4274, 10/2016, Volume 259, pp. S247 - S247
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. S284 - S285
Journal Article