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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 29, pp. 10574 - 10579
Metformin, a first-line diabetes drug linked to cancer prevention in retrospective clinical analyses, inhibits cellular transformation and selectively kills... 
Lactates | Energy metabolism | Cellular metabolism | Epithelial cells | Cell lines | Stem cells | Glycolysis | Transformed cell line | Breast cancer | Cancer | Metabolic profiling | Cancer metabolism | Metabolism | COMPLEX I | RESPIRATORY-CHAIN | MULTIDISCIPLINARY SCIENCES | glycolysis | metabolic profiling | DECREASES | CHEMOTHERAPY | cancer metabolism | BREAST-CANCER | DIABETIC-PATIENTS | GROWTH | MITOCHONDRIAL DYSFUNCTION | metabolism | INFLAMMATORY RESPONSE | Biguanides - pharmacology | Ribonucleotides - metabolism | Neoplastic Stem Cells - drug effects | Humans | Metformin - pharmacology | Citric Acid Cycle - drug effects | Glycerophosphates - metabolism | Endoplasmic Reticulum - metabolism | Nucleotides - metabolism | Glycolysis - drug effects | Phenformin - pharmacology | Lactates - metabolism | Aminoimidazole Carboxamide - analogs & derivatives | Metabolome - drug effects | Neoplastic Stem Cells - metabolism | Endoplasmic Reticulum - drug effects | Tamoxifen - pharmacology | src-Family Kinases - metabolism | Cell Line, Tumor | Folic Acid - metabolism | Neoplastic Stem Cells - pathology | Aminoimidazole Carboxamide - metabolism | Cell Line, Transformed | Pharmaceutical research | Stem cell research | Analysis | Drug interactions | Cancer cells | Dosage and administration | Metformin | Research | Health aspects | Biological Sciences
Journal Article
Acta Physiologica, ISSN 1748-1708, 05/2009, Volume 196, Issue 1, pp. 81 - 98
As the liver is central in the maintenance of glucose homeostasis and energy storage, knowledge of the physiology as well as physiopathology of hepatic energy... 
hepatic glucose production | fatty liver | type 2 diabetes | AMP-activated protein kinase | liver | energy metabolism | AMP‐activated protein kinase | Type 2 diabetes | Energy metabolism | Fatty liver | Hepatic glucose production | Liver | PHYSIOLOGY | LIPID-METABOLISM | CREB COACTIVATOR TORC2 | ACETYL-COA CARBOXYLASE | MICE LACKING ADIPONECTIN | LIVER-DISEASE | ISOLATED RAT HEPATOCYTES | SKELETAL-MUSCLE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | ADIPOSE-TISSUE | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Hypoglycemic Agents - metabolism | Humans | Homeostasis | Protein Subunits - metabolism | Liver Cirrhosis - metabolism | Aminoimidazole Carboxamide - metabolism | Energy Metabolism - physiology | Protein Subunits - genetics | Liver Cirrhosis - drug therapy | Dyslipidemias - drug therapy | Ribonucleotides - metabolism | Fatty Liver - metabolism | Fatty Liver - physiopathology | Lipid Metabolism | Mitochondria - metabolism | AMP-Activated Protein Kinases - chemistry | Fatty Liver - drug therapy | Gluconeogenesis - physiology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Dyslipidemias - metabolism | Glucose - metabolism | Protein Conformation | Liver - cytology | Protein Subunits - chemistry | Liver Cirrhosis - physiopathology | AMP-Activated Protein Kinases - genetics | Dyslipidemias - physiopathology | Glucose metabolism | Enzymes | Liver diseases | Physiological aspects | Protein biosynthesis | Insulin resistance | Glucose | Protein kinases | Health aspects | Fatty acids | Dextrose | cytology | Protein Subunits | Dyslipidemias | AMP-Activated Protein Kinases | therapeutic | Hypoglycemic Agents | Aminoimidazole Carboxamide | Mitochondria | genetics | Gluconeogenesis | chemistry | drug therapy | physiology | Liver Cirrhosis | enzymology | Fatty Liver | physiopathology | Ribonucleotides | Energy Metabolism | analogs & derivatives | MP-activated protein kinase | metabolism
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Journal Article
RNA, ISSN 1355-8382, 05/2017, Volume 23, Issue 5, pp. 655 - 672
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e52852
Journal Article
Diabetes, ISSN 0012-1797, 01/2006, Volume 55, Issue 1, pp. 120 - 127
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis... 
DEPENDENT DIABETES-MELLITUS | OXIDATIVE STRESS | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | MUSCLE | RAT-HEART | COMPLICATIONS | AICAR | BLOOD-GLUCOSE CONTROL | INTENSIVE INSULIN THERAPY | NEPHROPATHY | Reactive Oxygen Species - metabolism | Humans | Multienzyme Complexes - metabolism | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Hyperglycemia - pathology | Aminoimidazole Carboxamide - metabolism | Protein-Serine-Threonine Kinases - metabolism | Superoxide Dismutase - metabolism | Ribonucleotides - metabolism | DNA, Mitochondrial - metabolism | Heat-Shock Proteins - metabolism | Metformin - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Multienzyme Complexes - genetics | Transcription Factors - genetics | Enzyme Activation - drug effects | NF-E2-Related Factor 1 - metabolism | Hypoglycemic Agents - pharmacology | Hyperglycemia - metabolism | Transcription Factors - metabolism | Aminoimidazole Carboxamide - analogs & derivatives | Endothelial Cells - cytology | Endothelial Cells - enzymology | Research | Diabetes | Endothelial growth factors | Health aspects | Protein kinases
Journal Article