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Structure, ISSN 0969-2126, 04/2018, Volume 26, Issue 4, pp. 580 - 589.e4
5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from Saccharomyces... 
ClpX | AAA+ unfoldase | porphyria | XLSA | XLPP | α-oxoamine family | sideroblastic anemia | BIOCHEMISTRY & MOLECULAR BIOLOGY | LINKED SIDEROBLASTIC ANEMIA | 5-AMINOLEVULINATE SYNTHASE | GLYCINE LOOP | FEATURES | CELL BIOLOGY | PHOSPHATE COFACTOR-BINDING | BIOPHYSICS | METABOLISM | SUCCINYL-COA SYNTHETASE | PURIFICATION | MUTATIONS | DOMINANT PROTOPORPHYRIA | Pyridoxal Phosphate - chemistry | Mitochondria - enzymology | Aminolevulinic Acid - chemistry | Saccharomyces cerevisiae - genetics | Protein Multimerization | Substrate Specificity | Crystallography, X-Ray | Protein Subunits - metabolism | Pyridoxal Phosphate - metabolism | Coenzymes - metabolism | Heme - chemistry | Mitochondria - genetics | Aminolevulinic Acid - metabolism | Heme - biosynthesis | Cloning, Molecular | Escherichia coli - metabolism | 5-Aminolevulinate Synthetase - metabolism | Protein Interaction Domains and Motifs | Coenzymes - chemistry | Mitochondria - chemistry | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | 5-Aminolevulinate Synthetase - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - chemistry | Amino Acid Motifs | Protein Conformation, beta-Strand | Escherichia coli - genetics | 5-Aminolevulinate Synthetase - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Subunits - chemistry | Kinetics | Mutation | Amino Acid Substitution | Saccharomyces cerevisiae Proteins - chemistry | Phosphates | Enzymes | Anemia | Analysis | Heme | Crystals | Hemoglobin synthesis | Structure | BASIC BIOLOGICAL SCIENCES | ClpXAAA+ unfoldase | AAA+ | unfoldase | Sideroblastic anemia
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 01/2019, Volume 203, pp. 203 - 213
Journal Article
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 01/2019, Volume 83, pp. 400 - 413
[Display omitted] Multi-stimuli-responsive theranostic nanoplatform integrating functions of both imaging and multimodal therapeutics holds great promise for... 
Gold nanorod | Hyaluronic acid | Targeted delivery | Triple-responsive drug release | Photodynamic and photothermal dual-therapy | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | PH-DRIVEN | PHOTOSENSITIZER | LIGHT | PHOTOTHERMAL ABLATION | DRUG-RELEASE | COMBINATION | Photodynamic and photothermal dual therapy | CHEMOTHERAPY | DELIVERY | NANOPARTICLES | DYE | Aminolevulinic Acid - chemistry | Antineoplastic Agents, Immunological - pharmacokinetics | Humans | Hyaluronic Acid - pharmacology | Antineoplastic Agents, Immunological - chemistry | Photochemotherapy | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Nanotubes - chemistry | MCF-7 Cells | Hyperthermia, Induced | Female | Gold - chemistry | Metal Nanoparticles - chemistry | Aminolevulinic Acid - pharmacology | Hyaluronic Acid - chemistry | Metal Nanoparticles - therapeutic use | Gold - pharmacology | Hyaluronic Acid - pharmacokinetics | Antineoplastic Agents, Immunological - pharmacology | Xenograft Model Antitumor Assays | Aminolevulinic Acid - pharmacokinetics | Gold - pharmacokinetics | Animals | Breast Neoplasms - pathology | Mice, Nude | Mice | Mice, Inbred BALB C | Care and treatment | Fluorescence | Breast cancer | Health aspects | Cancer | Therapy | Drug delivery systems | Aminolevulinic acid | pH effects | Cancer therapies | CD44 antigen | Bioaccumulation | Chemical bonds | Glutathione | Gold | Photodynamic therapy | Medical imaging | I.R. radiation | Pharmacology | Light therapy | ErbB-2 protein | Organic chemistry | Side effects | Acids | Irradiation | Nanorods | Stimuli | Tumors
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 07/2013, Volume 8, Issue 1, pp. 2669 - 2676
Background: 5-Aminolevulinic acid (ALA) is a prodrug for topical photodynamic therapy. The effectiveness of topical ALA can be limited by its bioavailability.... 
Nanoparticles | Skin squamous cell carcinoma | 5-Aminolevulinic acid (ALA) | Poly(lactic-co-glycolic acid) (PLGA) | Photodynamic therapy (PDT) | poly(lactic-co-glycolic acid) (PLGA) | PHOTODYNAMIC THERAPY | DELTA-AMINOLEVULINIC-ACID | WORKERS | NANOSCIENCE & NANOTECHNOLOGY | CANCER | CELLULAR UPTAKE | DELIVERY | nanoparticles | skin squamous cell carcinoma | PLASMA | ESTERS | PHARMACOLOGY & PHARMACY | photodynamic therapy (PDT) | SKIN | NANOTECHNOLOGY | Aminolevulinic Acid - toxicity | Cell Survival - drug effects | Microscopy, Electron, Transmission | Aminolevulinic Acid - chemistry | Lactic Acid - chemistry | Photosensitizing Agents - chemistry | Nanoparticles - chemistry | Photochemotherapy - methods | Humans | Polyglycolic Acid - toxicity | Cell Survival - radiation effects | Nanoparticles - toxicity | Particle Size | Lactic Acid - pharmacokinetics | Aminolevulinic Acid - pharmacokinetics | Analysis of Variance | Polyglycolic Acid - pharmacokinetics | Photosensitizing Agents - toxicity | Polyglycolic Acid - chemistry | Cell Line, Tumor | Photosensitizing Agents - pharmacokinetics | Calorimetry, Differential Scanning | Lactic Acid - toxicity | Kinetics | Drugs | Drug delivery systems | Photosensitizing compounds | Research | Photochemotherapy | Health aspects | Vehicles | Cancer | Photodynamic therapy | Original Research
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 11/2017, Volume 14, Issue 11, pp. e1700197 - n/a
Journal Article
Journal Article
ChemSusChem, ISSN 1864-5631, 03/2016, Volume 9, Issue 6, pp. 562 - 582
Journal Article