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The New England journal of medicine, ISSN 1533-4406, 11/2017, Volume 377, Issue 21, pp. 2013 - 2023
Journal Article
The New England journal of medicine, ISSN 1533-4406, 11/2017, Volume 377, Issue 21, pp. 2024 - 2035
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 10/2009, Volume 106, Issue 44, pp. 18825 - 18830
.... Here we describe the in vitro pharmacology of VX-770, an orally bioavailable CFTR potentiator in clinical development for the treatment of CF... 
3T3 cells | Lungs | Secretion | Epithelial cells | Lung diseases | Bronchi | Cystic fibrosis | Pharmacology | Genetic mutation | Cilia | Epithelial sodium channel (ENaC) | Cystic fibrosis transmembrane conductance regulator (CFTR) | Epithelial ion transport | Human bronchial epithelium (HBE) culture | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | NIH 3T3 Cells | Epithelial Cells - metabolism | Aminophenols - chemistry | Cystic Fibrosis - physiopathology | Epithelial Cells - drug effects | Humans | Quinolones - pharmacology | Epithelial Sodium Channels - metabolism | Sodium - metabolism | Aminophenols - pharmacology | Quinolines - pharmacology | Amino Acid Substitution - drug effects | Quinolones - chemistry | Chlorides - metabolism | Cilia - drug effects | Bronchi - pathology | Quinolines - chemistry | Cells, Cultured | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Mutation - genetics | Cilia - metabolism | Drug Synergism | Animals | Absorption - drug effects | Mice | Ion Channel Gating - drug effects | Care and treatment | Chemical properties | Protein kinases | Health aspects | Proteins | Cell culture | Membranes | Mutation | Gene expression | Kinases | Index Medicus | Biological Sciences | epithelial sodium channel (ENaC) | cystic fibrosis transmembrane conductance regulator (CFTR) | epithelial ion transport | human bronchial epithelium (HBE) culture
Journal Article
Journal of antibiotics, ISSN 1881-1469, 09/2011, Volume 64, Issue 11, pp. 705 - 710
Platensimycin and platencin are novel antibiotics produced by Streptomyces platensis. They are potent and non-toxic natural products active against... 
Analogs | Antibiotic | Platencin | Strain improvement | Platensimycin | Chemical synthesis | Streptomyces platensis | Pharmacology & Pharmacy | Immunology | Life Sciences & Biomedicine | Microbiology | Biotechnology & Applied Microbiology | Science & Technology | Anilides - therapeutic use | Aminophenols - pharmacokinetics | Gram-Positive Bacteria - drug effects | Humans | Aminophenols - therapeutic use | Anilides - pharmacokinetics | Aminobenzoates - therapeutic use | Aminophenols - pharmacology | Streptomyces - metabolism | Anti-Bacterial Agents - therapeutic use | Gram-Positive Bacterial Infections - microbiology | Adamantane - therapeutic use | Molecular Structure | Adamantane - pharmacokinetics | Polycyclic Compounds - metabolism | Adamantane - pharmacology | Adamantane - metabolism | Anilides - metabolism | Models, Molecular | Anti-Bacterial Agents - metabolism | Aminophenols - metabolism | Polycyclic Compounds - pharmacology | Polycyclic Compounds - pharmacokinetics | Aminobenzoates - metabolism | Anilides - pharmacology | Anti-Bacterial Agents - pharmacokinetics | Lipid Metabolism - drug effects | Aminobenzoates - pharmacology | Anti-Bacterial Agents - pharmacology | Polycyclic Compounds - therapeutic use | Gram-Positive Bacterial Infections - drug therapy | Aminobenzoates - pharmacokinetics | Fatty Acids - biosynthesis | Index Medicus
Journal Article
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 10/2018, Volume 379, Issue 17, pp. 1612 - 1620
This preclinical, phase 2 report shows that VX-445, a CFTR potentiator when administered with tezacaftor and ivacaftor, improved lung function and reduced... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pyrazoles - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Pyrrolidines - administration & dosage | Chloride Channel Agonists - therapeutic use | Male | Aminophenols - therapeutic use | Chloride Channel Agonists - adverse effects | Aminophenols - adverse effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Sweat - chemistry | Young Adult | Quinolones - adverse effects | Chlorides - metabolism | Quinolones - therapeutic use | Adult | Benzodioxoles - adverse effects | Female | Benzodioxoles - therapeutic use | Pyrazoles - pharmacology | Pyridines - therapeutic use | Pyridines - administration & dosage | Double-Blind Method | Genotype | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Chlorides - analysis | Pyrazoles - administration & dosage | Indoles - adverse effects | Cystic Fibrosis - genetics | Adolescent | Alleles | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Indoles - therapeutic use | Pyridines - pharmacology | Mutation | Cystic Fibrosis - drug therapy | Drug Combinations | Cystic fibrosis | Ivacaftor | Dosage and administration | Drug therapy | Statistical analysis | Writers | Epithelial cells | Chloride transport | Recovery of function | Patients | Design | Proteins | Genotype & phenotype | Chloride | Collaboration | Conductance | Cystic fibrosis transmembrane conductance regulator | Protein transport | Sweat | Pharmaceuticals | Index Medicus | Abridged Index Medicus
Journal Article