X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (291) 291
aminopterin - analogs & derivatives (288) 288
animals (225) 225
aminopterin - pharmacology (191) 191
aminopterin - therapeutic use (141) 141
methotrexate (138) 138
oncology (134) 134
female (129) 129
mice (118) 118
aminopterin (107) 107
male (104) 104
folic acid antagonists - pharmacology (94) 94
index medicus (85) 85
methotrexate - pharmacology (83) 83
aminopterin - administration & dosage (76) 76
middle aged (76) 76
pharmacology & pharmacy (74) 74
aged (73) 73
adult (69) 69
aminopterin - adverse effects (68) 68
folic acid antagonists - therapeutic use (68) 68
folate analogs (61) 61
structure-activity relationship (61) 61
antineoplastic agents - therapeutic use (60) 60
antineoplastic combined chemotherapy protocols - therapeutic use (55) 55
aminopterin - metabolism (53) 53
folic acid - analogs & derivatives (53) 53
10-deaza-aminopterin series (52) 52
kinetics (51) 51
antifolate (48) 48
chemotherapy (46) 46
methotrexate - analogs & derivatives (45) 45
cell division - drug effects (43) 43
cell line (43) 43
folic acid antagonists (43) 43
tetrahydrofolate dehydrogenase - metabolism (42) 42
folic acid (41) 41
pralatrexate (41) 41
methotrexate - therapeutic use (40) 40
tumor cells, cultured (37) 37
cancer (36) 36
edatrexate (36) 36
treatment outcome (36) 36
aminopterin - chemical synthesis (35) 35
lung neoplasms - drug therapy (35) 35
methotrexate - metabolism (35) 35
rats (34) 34
dose-response relationship, drug (33) 33
chemistry, medicinal (32) 32
antineoplastic agents - pharmacology (31) 31
biochemistry & molecular biology (31) 31
carcinoma, non-small-cell lung - drug therapy (31) 31
dihydrofolate reductase (31) 31
leukemia l1210 - drug therapy (31) 31
dihydrofolate-reductase (30) 30
drug administration schedule (30) 30
folic acid antagonists - chemical synthesis (30) 30
folic acid antagonists - adverse effects (29) 29
aminopterin - pharmacokinetics (28) 28
folic acid antagonists - administration & dosage (27) 27
research (27) 27
antitumor-activity (26) 26
folic acid antagonists - metabolism (26) 26
leucovorin (26) 26
antineoplastic agents - adverse effects (25) 25
drug resistance (25) 25
antineoplastic agents - chemical synthesis (24) 24
folic acid - pharmacology (24) 24
phase-ii (24) 24
clinical trials as topic (23) 23
folic acid antagonists - pharmacokinetics (23) 23
10-propargyl-10-deazaaminopterin (22) 22
folic acid - metabolism (22) 22
folic-acid (22) 22
hematology (22) 22
aminopterin - toxicity (21) 21
chemistry (21) 21
mutation (21) 21
neoplasms - drug therapy (21) 21
time factors (21) 21
aged, 80 and over (20) 20
aminopterin - chemistry (20) 20
in vitro techniques (20) 20
methotrexate - administration & dosage (20) 20
10-ethyl-10-deaza-aminopterin (19) 19
analogs (19) 19
liver - enzymology (19) 19
molecular structure (19) 19
folic acid antagonists - chemistry (18) 18
inhibition (18) 18
lymphoma, t-cell, peripheral - drug therapy (18) 18
pharmacology (18) 18
antimetabolites (17) 17
cell lung-cancer (17) 17
chemical phenomena (17) 17
cisplatin (17) 17
drug screening assays, antitumor (17) 17
peptide synthases - antagonists & inhibitors (17) 17
polyglutamic acid - metabolism (17) 17
acid (16) 16
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
CHEMICAL BIOLOGY & DRUG DESIGN, ISSN 1747-0277, 03/2016, Volume 87, Issue 3, pp. 444 - 454
Based on our previous work, seven N-5-substituted 8,10-dideazatetrahydrofolate analogues and one 8-deazatetrahydrofolate analogue were designed and synthesized... 
10-DEAZA-AMINOPTERIN SERIES | DESIGN | CHEMISTRY, MEDICINAL | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOLATE ANALOGS | anticancer agents | SYNTHASE | POTENT | AGENTS | INHIBITORS | 8,10-Dideazatetrahydrofolate | THYMIDYLATE SYNTHETASE
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2013, Volume 13, Issue 2, pp. 364 - 372
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2000, Volume 6, Issue 12, pp. 4885 - 4892
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2009, Volume 27, Issue 26, pp. 4357 - 4364
Journal Article
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, ISSN 1520-4391, 12/2015, Volume 2015, Issue 1, pp. 529 - 544
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2002, Volume 45, Issue 8, pp. 1690 - 1696
Details are disclosed for the synthesis of N α-[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]-N δ-hemiphthaloyl-l-ornithine (2) and N... 
POTENT | CHEMISTRY, MEDICINAL | REDUCED FOLATE CARRIER | SIDE-CHAIN | DIHYDROFOLATE-REDUCTASE | BIOLOGICAL EVALUATION | METHOTREXATE | 10-PROPARGYL-10-DEAZAAMINOPTERIN | INHIBITORS | AMINOPTERIN | CYTOTOXICITY
Journal Article