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Journal of Inorganic Biochemistry, ISSN 0162-0134, 07/2016, Volume 160, pp. 125 - 139
Cobalt(II) complexes with a series of non-steroidal anti-inflammatory drugs (diflunisal, flufenamic acid, mefenamic acid and niflumic acid) in the presence of... 
Cobalt(II) complexes | Interaction with calf-thymus DNA | Interaction with albumins | Antioxidant activity | Non-steroidal anti-inflammatory drugs | MEFENAMIC-ACID | TRANSITION-METAL-COMPLEXES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINUCLEAR COPPER(II) COMPLEX | DNA-BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | TOLFENAMIC ACID STRUCTURE | FLUFENAMIC ACID | BIOLOGICAL EVALUATION | SCHIFF-BASE COMPLEXES | Free Radical Scavengers - chemistry | 2,2'-Dipyridyl - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Mefenamic Acid - chemistry | Aminopyridines - chemistry | Biphenyl Compounds - antagonists & inhibitors | Phenanthrolines - chemistry | Picrates - chemistry | Free Radical Scavengers - chemical synthesis | Biphenyl Compounds - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Intercalating Agents - chemical synthesis | Methanol - chemistry | Serum Albumin - chemistry | Binding Sites | Niflumic Acid - chemistry | 2,2'-Dipyridyl - chemistry | Models, Molecular | Coordination Complexes - chemistry | Intercalating Agents - chemistry | DNA - chemistry | Diflunisal - chemistry | Picrates - antagonists & inhibitors | Cations, Divalent | Flufenamic Acid - chemistry | Coordination Complexes - chemical synthesis | Kinetics | Cobalt - chemistry
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 09/2016, Volume 162, pp. 9 - 21
The reaction of NiCl with the non-steroidal anti-inflammatory drug diflunisal (Hdifl) resulted in the formation of complex [Ni(difl-O) (MeOH) ], . The... 
Nickel complexes | Diflunisal | Albumin-binding | Biological activity | DNA-binding | NONSTEROIDAL ANTIINFLAMMATORY DRUG | CRYSTAL-STRUCTURE | COPPER(II) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-BINDING | BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | TOLFENAMIC ACID STRUCTURE | ANTICANCER ACTIVITY | BIOLOGICAL PERSPECTIVES | BOVINE SERUM-ALBUMIN | METAL-COMPLEXES | Ethidium - chemistry | Free Radical Scavengers - chemistry | 2,2'-Dipyridyl - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Aminopyridines - chemistry | Sulfonic Acids - chemistry | Biphenyl Compounds - antagonists & inhibitors | Phenanthrolines - chemistry | Cattle | Hydroxyl Radical - chemistry | Picrates - chemistry | Free Radical Scavengers - chemical synthesis | Benzothiazoles - antagonists & inhibitors | Biphenyl Compounds - chemistry | Hydroxyl Radical - antagonists & inhibitors | Serum Albumin - chemistry | Binding, Competitive | Nickel - chemistry | 2,2'-Dipyridyl - chemistry | Models, Molecular | Coordination Complexes - chemistry | Sulfonic Acids - antagonists & inhibitors | DNA - chemistry | Diflunisal - chemistry | Picrates - antagonists & inhibitors | Animals | Benzothiazoles - chemistry | Coordination Complexes - chemical synthesis | Protein Binding | Antioxidants | Cytokinins | Nickel | Fluocinolone acetonide | DNA | Crystals | Albumin | Nonsteroidal anti-inflammatory drugs | Structure
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2017, Volume 12, Issue 7, pp. 487 - 501
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for... 
kinase inhibitors | pharmacophores | sulfoximines | drug design | medicinal chemistry | PHOSPHODIESTERASE-5 INHIBITORS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | DIELS-ALDER REACTIONS | DEPENDENT KINASE INHIBITOR | BREAST-CANCER | POTENT INHIBITOR | STRUCTURAL BASIS | CDK4/6 INHIBITOR | PHARMACOLOGY & PHARMACY | ERECTILE DYSFUNCTION | Estradiol - analogs & derivatives | Sulfoxides - chemical synthesis | Cyclin-Dependent Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Imatinib Mesylate - chemical synthesis | Pyrazoles - chemical synthesis | Pyridines - chemistry | Imatinib Mesylate - metabolism | Piperazines - metabolism | Piperazines - chemistry | Aminopyridines - metabolism | Fulvestrant | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Vardenafil Dihydrochloride - chemistry | Drug Design | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Purines - chemical synthesis | Estradiol - metabolism | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Piperidines - metabolism | Purines - metabolism | Pyridines - chemical synthesis | Pyrazoles - metabolism | Piperidines - chemical synthesis | Imatinib Mesylate - chemistry | Vardenafil Dihydrochloride - metabolism | Aminopyridines - chemical synthesis | Sulfoxides - chemistry | Estradiol - chemistry | Purines - chemistry | Pyridines - metabolism | Vardenafil Dihydrochloride - chemical synthesis | Sulfoxides - metabolism | Piperazines - chemical synthesis | Estradiol - chemical synthesis | Protein Kinase Inhibitors - metabolism | Drug discovery | Chemical properties | Pharmaceutical industry | Full Paper | Full Papers
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 09/2016, Volume 162, pp. 22 - 30
From the reaction of Cu(II) with the non-steroidal anti-inflammatory drug ketoprofen (Hketo), complex [Cu (keto) (H O) ] was isolated, while the presence of a... 
Interaction with CT DNA | Interaction with albumins | Copper(II) complexes | Antioxidant activity | Ketoprofen | TRANSITION-METAL-COMPLEXES | MOLECULAR-STRUCTURE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIFUNGAL ACTIVITY | NICKEL(II) COMPLEXES | PROTEIN-BINDING | CHEMISTRY, INORGANIC & NUCLEAR | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SUPEROXIDE-DISMUTASE | Ethidium - chemistry | Free Radical Scavengers - chemistry | 2,2'-Dipyridyl - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Ketoprofen - chemistry | Aminopyridines - chemistry | Sulfonic Acids - chemistry | Copper - chemistry | Biphenyl Compounds - antagonists & inhibitors | Phenanthrolines - chemistry | Cattle | Hydroxyl Radical - chemistry | Picrates - chemistry | Free Radical Scavengers - chemical synthesis | Benzothiazoles - antagonists & inhibitors | Biphenyl Compounds - chemistry | Hydroxyl Radical - antagonists & inhibitors | Serum Albumin - chemistry | Binding, Competitive | 2,2'-Dipyridyl - chemistry | Models, Molecular | Coordination Complexes - chemistry | Sulfonic Acids - antagonists & inhibitors | DNA - chemistry | Picrates - antagonists & inhibitors | Animals | Benzothiazoles - chemistry | Coordination Complexes - chemical synthesis | Protein Binding | Copper compounds | Cytokinins | Fluocinolone acetonide | Analysis | Antioxidants | Albumin | Fluorescence
Journal Article
European Journal of Inorganic Chemistry, ISSN 1434-1948, 01/2016, Volume 2016, Issue 1, pp. 56 - 63
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 2007, Volume 67, Issue 3, pp. 950 - 957
Journal Article
Journal Article
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 11/2015, Volume 13, Issue 44, pp. 10888 - 10894
The use of B(OCH2CF3)3 for mediating direct amidation reactions of a wide range of pharmaceutically relevant carboxylic acids and amines is described,... 
Amines - chemistry | Aminopyridines - chemistry | Solvents - chemistry | Carboxylic Acids - chemistry | Methyl Ethers - chemistry | Amides - chemistry | Cyclopentanes - chemistry | Catalysis | Borates - chemistry | Esterification | Phenylacetates - chemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62721
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small... 
TARGET | CRYSTALLIZATION | CELL-MEMBRANE | TGF-BETA | ZEBRAFISH | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | PROMOTE PROTEIN STABILITY | RECEPTOR | BONE | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | Activin Receptors, Type I - antagonists & inhibitors | Body Patterning - drug effects | Bone Morphogenetic Proteins - antagonists & inhibitors | Neovascularization, Physiologic - drug effects | Humans | Molecular Conformation | Models, Molecular | Zebrafish | Pyrimidines - pharmacology | Aminopyridines - chemistry | Bone Morphogenetic Proteins - metabolism | Protein Kinase Inhibitors - chemistry | Animals | Signal Transduction - drug effects | Aminopyridines - pharmacology | Protein Binding | Phenols - chemistry | Protein Kinase Inhibitors - pharmacology | Bone Morphogenetic Proteins - chemistry | Smad Proteins - metabolism | Activin Receptors, Type I - chemistry | Phenols - pharmacology | Pyrazoles - pharmacology | Analysis | Crystals | Bone morphogenetic proteins | Drug discovery | Transforming growth factors | Structure | Phosphotransferases | Phosphorylation | Smad protein | Laboratories | Genomics | Identification | Kinases | Medical schools | Optimization | Proteins | Consortia | Signal transduction | Neurodegeneration | Crystal structure | Recombinant | Medical research | Complementarity | Research & development--R&D | Pharmacology | Myositis ossificans | Embryos | Signaling | Hospitals | Inhibitors | Phenols | Pharmacokinetics | Cancer | Research & development | R&D
Journal Article