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Nature (London), ISSN 1476-4687, 04/2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Plant molecular biology, ISSN 0167-4412, 1/2013, Volume 81, Issue 1, pp. 27 - 40
Journal Article
Nature cell biology, ISSN 1476-4679, 02/2007, Volume 9, Issue 3, pp. 299 - 309
Non-muscle myosin II has diverse functions in cell contractility, cytokinesis and locomotion, but the specific contributions of its different isoforms have yet... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Nonmuscle Myosin Type IIA - antagonists & inhibitors | Embryonic Stem Cells - metabolism | RNA, Small Interfering - genetics | Embryonic Stem Cells - cytology | Humans | Nocodazole - pharmacology | Cercopithecus aethiops | Cell Movement - physiology | Heterocyclic Compounds, 4 or More Rings - pharmacology | Microtubules - metabolism | Nonmuscle Myosin Type IIB - antagonists & inhibitors | Transfection | Nonmuscle Myosin Type IIA - physiology | Guanine Nucleotide Exchange Factors - metabolism | Microtubules - drug effects | Nonmuscle Myosin Type IIA - genetics | Kinesin - genetics | Aminoquinolines - pharmacology | Kinesin - antagonists & inhibitors | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Nonmuscle Myosin Type IIB - physiology | Fibroblasts - metabolism | Guanine Nucleotide Exchange Factors - genetics | Nonmuscle Myosin Type IIB - genetics | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Actomyosin - metabolism | Kinesin - metabolism | Naphthalenes - pharmacology | Azepines - pharmacology | Cell Movement - drug effects | Animals | Embryonic Stem Cells - drug effects | Cell Adhesion - physiology | Fibroblasts - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Fibroblasts - cytology | Mice | Vinblastine - pharmacology | Thiones - pharmacology | COS Cells | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Evaluation | Motility | Microtubules | Myosin | Physiological aspects | Genetic aspects | Properties | Health aspects | Cells | Index Medicus
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6417 - 6426
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 07/2005, Volume 102, Issue 31, pp. 11011 - 11016
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 05/2012, Volume 109, Issue 21, pp. 8253 - 8258
Autophagy is a lysosome-dependent degradative process that protects cancer cells from multiple stresses. In preclinical models, autophagy inhibition with... 
Cell death | Medical treatment | Cell lines | Lysosomes | Immunoblotting | Cytotoxicity | Dosage | Heterologous transplantation | Tumors | Cancer | Antimalarials | Cancer cell survival | Stress responses | Drug resistance | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Autophagy-Related Proteins | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Aminoquinolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Colonic Neoplasms - drug therapy | Humans | Brain Neoplasms - pathology | Aminoquinolines - toxicity | Drug Resistance, Neoplasm | Polyamines - toxicity | Intestinal Obstruction - chemically induced | Autophagy - drug effects | Antineoplastic Agents - toxicity | Glioblastoma - genetics | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Autophagy - genetics | Cell Death - drug effects | Aminoquinolines - pharmacology | Lysosomes - drug effects | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Antimalarials - pharmacology | HT29 Cells | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Polyamines - pharmacology | Animals | Mice, Nude | Colonic Neoplasms - pathology | Glioblastoma - pathology | Hydroxychloroquine - pharmacology | Mice | Glioblastoma - drug therapy | Intestinal Obstruction - genetics | Polyamines - chemical synthesis | Autophagy (Cytology) | Phenotype | Genetic aspects | Dosage and administration | Enzyme inhibitors | Identification and classification | Index Medicus | antimalarials | Biological Sciences | cancer cell survival | drug resistance | cell death | stress responses
Journal Article