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1. Full Text Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A(2A) and A(1) antagonists
by Randall, PA and Nunes, EJ and Janniere, SL and Stopper, CM and Farrar, AM and Sager, TN and Baqi, Y and Hockemeyer, J and Muller, CE and Salamone, JD
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 07/2011, Volume 216, Issue 2, pp. 173 - 186
Adenosine A(2A) antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on instrumental behavior. However, little is... 
Dopamine | RECEPTOR ANTAGONISTS | PSYCHIATRY | CAFFEINE | Depression | Activation | Anergia | SCHEDULE-CONTROLLED BEHAVIOR | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Parkinsonism | SYMPATHOMIMETIC AMINES | LOCOMOTOR SUPPRESSION | DECISION-MAKING | Psychomotor slowing | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | MSX-3 REVERSES | Adenosine | Analysis | Theophylline | Caffeine
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2. Full Text Dopamine and serotonin antagonists fail to alter the discriminative stimulus properties of ±methylenedioxymethamphetamine
by Schenk, Susan and Highgate, Quenten
Behavioural Pharmacology, ISSN 0955-8810, 06/2019, Volume 30, Issue 4, pp. 327 - 334
Most studies on discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) have been conducted using a relatively low dose (1.5 mg/kg), and... 
4-methylenedioxymethamphetamine | MEDIATION | rat | (+)-AMPHETAMINE | amphetamine | COCAINE | DEPLETION | NEUROSCIENCES | serotonin | RECEPTOR SUBTYPES | drug discrimination | RITANSERIN | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | dopamine
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3. Full Text Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist ( + )-Naltrexone on Incubation of Heroin Craving
by Theberge, Florence R and Li, Xuan and Kambhampati, Sarita and Pickens, Charles L and St. Laurent, Robyn and Bossert, Jennifer M and Baumann, Michael H and Hutchinson, Mark R and Rice, Kenner C and Watkins, Linda R and Shaham, Yavin
Biological Psychiatry, ISSN 0006-3223, 2013, Volume 73, Issue 8, pp. 729 - 737
Background Recent evidence implicates toll-like receptor 4 (TLR4) in opioid analgesia, tolerance, conditioned place preference, and self-administration. Here,... 
Psychiatry | extinction | reinstatement | relapse | Craving | opioid drugs | glia | heroin self-administration | TLR4 | DRUG-DEPENDENCE | CONDITIONED IMMUNOMODULATION | PSYCHIATRY | COCAINE-SEEKING | DOPAMINE D-1-FAMILY RECEPTORS | FACTOR-KAPPA-B | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | STRESS-INDUCED REINSTATEMENT | TIME-DEPENDENT CHANGES | CENTRAL-NERVOUS-SYSTEM | Behavior, Addictive - drug therapy | Cues | Naltrexone - therapeutic use | Drug Administration Schedule | Stereoisomerism | Extinction, Psychological - drug effects | Rats | Dose-Response Relationship, Drug | Naltrexone - pharmacology | Self Administration | Animals | Conditioning, Operant - drug effects | Narcotic Antagonists - therapeutic use | Time Factors | Methamphetamine - administration & dosage | Narcotic Antagonists - pharmacology | Heroin - administration & dosage | Toll-Like Receptor 4 - antagonists & inhibitors | Infusion Pumps, Implantable - psychology | Naltrexone - administration & dosage | Physiological aspects | Naltrexone | Heroin | craving
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4. Antidepressant-like effects of κ-opioid receptor antagonists in the forced swim test in rats
by Mague, Stephen D and Pliakas, Andrea M and Todtenkopf, Mark S and Tomasiewicz, Hilarie C and Zhang, Yan and Stevens Jr, William C and Jones, Robert M and Portoghese, Philip S and Carlezon Jr, William A
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2003, Volume 305, Issue 1, pp. 323 - 330
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test... 
DEPRESSION | STIMULATION | SENSITIZATION | DRUGS | COCAINE WITHDRAWAL | DOPAMINE | PHARMACOLOGY & PHARMACY | NUCLEUS-ACCUMBENS SHELL | BRAIN REWARD PATHWAYS | AMPHETAMINE | 5'-GUANIDINONALTRINDOLE | Receptors, Opioid, kappa - antagonists & inhibitors | Animals | Narcotic Antagonists - pharmacology | Motor Activity - drug effects | Rats | Male | Models, Animal | Antidepressive Agents - pharmacology | Swimming | Rats, Sprague-Dawley
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5. Full Text N-Methyl d-Aspartate Receptor Antagonists Ketamine and MK-801 Induce Wake-Related Aberrant γ Oscillations in the Rat Neocortex
by Pinault, Didier
Biological Psychiatry, ISSN 0006-3223, 2008, Volume 63, Issue 8, pp. 730 - 735
Background Single subanesthetic doses of ketamine, a non-competitive NMDA receptor (NMDAr) antagonist, induce cognitive impairment, schizophreniform psychosis,... 
Psychiatry | electrocorticogram | neural synchrony | d-amphetamine | schizophrenia | Apomorphine | glutamate | Dopamine Agonists - pharmacology | Receptors, N-Methyl-D-Aspartate - drug effects | Wakefulness - drug effects | Dextroamphetamine - pharmacology | Dopamine Uptake Inhibitors - pharmacology | Rats, Wistar | Rats | Male | Excitatory Amino Acid Antagonists - pharmacology | Nerve Net - drug effects | Arousal - drug effects | Cortical Synchronization | Neocortex - drug effects | Animals | Apomorphine - pharmacology | Electroencephalography - drug effects | Injections, Subcutaneous | Synaptic Transmission - drug effects | Dizocilpine Maleate - pharmacology | Ketamine - pharmacology | Life Sciences | Human health and pathology | Neurons and Cognition | Psychiatrics and mental health
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6. Full Text Noradrenergic antagonists mitigate amphetamine-induced recovery
by Hylin, M.J and Brenneman, M.M and Corwin, J.V
Behavioural Brain Research, ISSN 0166-4328, 09/2017, Volume 334, pp. 61 - 71
Brain injury, including that due to stroke, leaves individuals with cognitive deficits that can disrupt daily aspect of living. As of now there are few... 
Recovery of function | Amphetamine | Noradrenaline | Brain injury | MEDIAL AGRANULAR CORTEX | BRAIN-INJURY | NEUROTROPHIC FACTOR | FIBROBLAST-GROWTH-FACTOR | UNILATERAL LESIONS | NEUROSCIENCES | VAGUS NERVE-STIMULATION | BEHAVIORAL RECOVERY | POSTERIOR PARIETAL CORTEX | DORSOMEDIAL PREFRONTAL CORTEX | BEHAVIORAL SCIENCES | MOTOR RECOVERY | Brain | Analysis | Therapeutics | Central nervous system agents | Injuries | Homeopathy | Materia medica and therapeutics
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7. Full Text Attenuation of the disruptive effects of (+/‐)3,4‐methylenedioxymethamphetamine and cocaine on delayed matching‐to‐sample performance with D1 versus D2 antagonists
by Harper, David N
Addiction Biology, ISSN 1355-6215, 11/2013, Volume 18, Issue 6, pp. 912 - 920
ABSTRACT Evidence suggests that acute exposure to (+/‐)3,4‐methylenedioxymethamphetamine (MDMA) produces qualitatively similar effects on recognition task... 
Cocaine | memory | delayed matching to sample | dopamine | MDMA | PROACTIVE-INTERFERENCE | COGNITIVE PERFORMANCE | DOPAMINE RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | SUBSTANCE ABUSE | SHORT-TERM-MEMORY | PREFRONTAL CORTEX | RECEPTOR ANTAGONIST | ECSTASY MDMA | D-AMPHETAMINE | WORKING-MEMORY | Receptors, Dopamine D1 - antagonists & inhibitors | Neurotransmitter Uptake Inhibitors - adverse effects | Neurotransmitter Uptake Inhibitors - antagonists & inhibitors | Humans | N-Methyl-3,4-methylenedioxyamphetamine - adverse effects | Injections, Intraperitoneal | Rats | Male | Psychomotor Performance - drug effects | Benzazepines - pharmacology | Animals | Recognition (Psychology) - drug effects | Analysis of Variance | Time Factors | Dopamine Antagonists - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - antagonists & inhibitors | Cocaine - adverse effects | Dopamine D2 Receptor Antagonists | Salicylamides - pharmacology | Cocaine - antagonists & inhibitors | Memory | Analysis | Ecstasy (Drug) | Resveratrol | Addiction
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8. Full Text Impulsivity moderates the effects of dopamine D2 and mixed D1–D2 antagonists in individuals with gambling disorder
by Zack, Martin and Lobo, Daniela and Biback, Candice and Fang, Tim and Smart, Kelly and Tatone, Daniel and Kalia, Aditi and Digiacomo, Daniel and Kennedy, James L
Journal of Psychopharmacology, ISSN 0269-8811, 8/2019, Volume 33, Issue 8, pp. 1015 - 1029
Background: The functional role of dopamine D1 and D2 receptors in gambling disorder (GD) remains unclear. Aims: This study aimed to investigate the role of D1... 
amphetamine | impulsivity | Gambling | dopamine | DRUG | HALOPERIDOL | PSYCHIATRY | BEHAVIORAL SENSITIZATION | LOCOMOTOR-ACTIVITY | RECEPTOR | PATHOLOGICAL GAMBLERS | REWARD | NEUROSCIENCES | CLINICAL NEUROLOGY | NUCLEUS-ACCUMBENS | PHARMACOLOGY & PHARMACY | SUBJECTIVE RESPONSES | D-AMPHETAMINE | Impulsivity | Dopamine | Activation | Antagonists | Haloperidol | Receptors | Dopamine D1 receptors | Fluphenazine | Amphetamine | Salience | Games | Legalized gambling | Impulsive behavior | Dopamine D2 receptors | Gaming machines
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9. Full Text N -methyl- d -aspartic acid receptor antagonist–induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
by Ehrlichman, R.S and Gandal, M.J and Maxwell, C.R and Lazarewicz, M.T and Finkel, L.H and Contreras, D and Turetsky, B.I and Siegel, S.J
Neuroscience, ISSN 0306-4522, 2009, Volume 158, Issue 2, pp. 705 - 712
Abstract Introduction: Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in... 
Neurology | NMDA | electroencephalography | frequency oscillations | animal model | RAT | PREPULSE INHIBITION | NETWORKS | GAMMA-OSCILLATIONS | NEUROSCIENCES | MISMATCH NEGATIVITY | KETAMINE | IN-VITRO | AUDITORY-EVOKED POTENTIALS | DOPAMINE | ACOUSTIC STARTLE | Schizophrenia - chemically induced | Evoked Potentials, Auditory - drug effects | Mice, Inbred C57BL | Risperidone - pharmacology | Amphetamine - administration & dosage | Male | Electroencephalography | Biological Clocks - drug effects | Acoustic Stimulation - methods | Ketamine - adverse effects | Animals | Drug Interactions | Schizophrenia - physiopathology | Reaction Time - drug effects | Mice | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Central Nervous System Stimulants - administration & dosage | Excitatory Amino Acid Antagonists - adverse effects | Haloperidol - pharmacology | Disease Models, Animal | Index Medicus
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10. Full Text Serotonin antagonists fail to alter MDMA self-administration in rats
by Schenk, Susan and Foote, Jason and Aronsen, Dane and Bukholt, Natasha and Highgate, Quenten and Van de Wetering, Ross and Webster, Jeremy
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 09/2016, Volume 148, pp. 38 - 45
Acute exposure to ± 3,4-methylenedioxymethamphetamine (MDMA) preferentially increases release of serotonin (5-HT), and a role of 5-HT in many of the behavioral... 
Self-administration | Hyperactivity | Serotonin receptors | Reinstatement | MDMA | FREELY MOVING RATS | ECSTASY DEPENDENCE | COCAINE-SEEKING BEHAVIOR | 5-HT2C RECEPTORS | RHESUS-MONKEYS | CUE-INDUCED REINSTATEMENT | LOCOMOTOR-ACTIVITY | NEUROSCIENCES | RECEPTOR ANTAGONIST | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | Ketanserin - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage | Rats | Male | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Drug-Seeking Behavior - drug effects | Self Administration | Animals | Extinction, Psychological | Oxadiazoles - pharmacology | Pyridines - pharmacology | Phenols | Central nervous system agents | Ecstasy (Drug) | Resveratrol | Cocaine
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11. Full Text Capturing the Angel in "Angel Dust": Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans
by Moghaddam, B and Krystal, JH
SCHIZOPHRENIA BULLETIN, ISSN 0586-7614, 09/2012, Volume 38, Issue 5, pp. 942 - 949
Here, we describe our collaborative efforts to use N-methyl-D-aspartate (NMDA) receptor antagonists as a translational tool to advance our understanding of the... 
PSYCHIATRY | GLUTAMATERGIC DYSFUNCTION | RATS | SCHIZOPHRENIA | PREFRONTAL CORTEX | PHENCYCLIDINE | ketamine | SUBANESTHETIC KETAMINE | NMDA | DOPAMINE | HEALTHY-VOLUNTEERS | AMPHETAMINE | glutamate | WORKING-MEMORY | Receptors, Metabotropic Glutamate - drug effects | Phencyclidine - pharmacology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Neurosciences | Humans | Receptors, Metabotropic Glutamate - physiology | Emotions - drug effects | Cerebral Cortex - physiopathology | Allosteric Regulation - physiology | Psychoses, Substance-Induced - physiopathology | Antipsychotic Agents - therapeutic use | Schizophrenia - physiopathology | Receptors, Dopamine D2 - drug effects | Receptor, Metabotropic Glutamate 5 | Cerebral Cortex - drug effects | Dopamine - metabolism | Disease Models, Animal | Allosteric Regulation - drug effects | Emotions - physiology | Phencyclidine - antagonists & inhibitors | Synapses - drug effects | Synapses - physiology | Translational Medical Research | Glutamic Acid - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Brief Psychiatric Rating Scale | Animals | Receptors, Dopamine D2 - physiology | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Ketamine - pharmacology
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12. Full Text Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague–Dawley rats
by Gutierrez, Arnold and Regan, Samantha L and Hoover, Christopher S and Williams, Michael T and Vorhees, Charles V
Psychopharmacology, ISSN 0033-3158, 7/2019, Volume 236, Issue 7, pp. 2243 - 2258
Methamphetamine (MA) is an abused psychostimulant that causes cognitive deficits after chronic use. Neostriatal dopamine receptors play a role in MA monoamine... 
Dopamine D2 antagonist | Neurosciences | Rat | Methamphetamine | Dopamine D1 antagonist | Sulpiride | Monoamines | Spatial learning | Biomedicine | SCH-23390 | Egocentric learning | Pharmacology/Toxicology | Psychiatry | CAUDATE-PUTAMEN | PSYCHIATRY | MORRIS WATER MAZE | PATH-INTEGRATION | NEUROSCIENCES | NUCLEUS-ACCUMBENS | COGNITIVE IMPAIRMENTS | DOUBLE DISSOCIATION | STRIATAL DOPAMINE | TRANSPORTER FUNCTION | PHARMACOLOGY & PHARMACY | INDUCED NEUROTOXICITY | RECEPTORS | Animal experimentation | Phenols | Dopamine receptors | Water treatment | Drug abuse | Spatial discrimination learning | Cognitive ability | Activation | Antagonists | Navigation behavior | Learning | Neurotoxicity | Receptors | Methamphetamines | Rodents | Neostriatum | Attenuation | Pretreatment | Dopamine D2 receptors | Dopamine | Serotonin | Animal memory | Maze learning | Gliosis | Dopamine D1 receptors | Spatial memory
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