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Nature Cell Biology, ISSN 1465-7392, 12/2009, Volume 11, Issue 12, pp. 1444 - 1450
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 7/2013, Volume 113, Issue 3, pp. 441 - 449
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e65403 - e65403
Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene... 
ACTIVATED PROTEIN-KINASE | PATHWAY | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | DEGRADATION | MECHANISMS | COOPERATION | CANCER | SONIC-HEDGEHOG | Interleukin-8 - genetics | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Hedgehog Proteins - metabolism | Gene Expression Profiling | Vascular Endothelial Growth Factor A - metabolism | Hedgehog Proteins - agonists | Vascular Endothelial Growth Factor A - genetics | Dermis - drug effects | Matrix Metalloproteinase 7 - metabolism | Medulloblastoma - pathology | Biomarkers, Tumor - metabolism | Cerebellar Neoplasms - pathology | Interleukin-8 - metabolism | Patched Receptors | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Cerebellar Neoplasms - metabolism | Fibroblasts - metabolism | Cerebellar Neoplasms - drug therapy | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Medulloblastoma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Fibroblasts - drug effects | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Zinc Finger Protein GLI1 | Patched-1 Receptor | Receptors, Cell Surface - genetics | Receptor, Epidermal Growth Factor - metabolism | Hedgehog Proteins - genetics | Cyclohexylamines - pharmacology | HEK293 Cells | Veratrum Alkaloids - pharmacology | Dermis - cytology | Dermis - metabolism | Enzyme-Linked Immunosorbent Assay | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Matrix Metalloproteinase 7 - genetics | Carrier Proteins - metabolism | Protein Array Analysis | Medulloblastoma - drug therapy | Genetic aspects | Epidermal growth factor | Medulloblastoma | Pancreatic cancer | Genes | Skin cancer | Regulators | Transcription factors | Transcription | Brain cancer | Genomics | Crosstalk | Signal strength | AKT protein | Genomes | Insulin-like growth factors | Amphiregulin | Kinases | Synergism | Proteins | Synergistic effects | Signal transduction | Immunology | Pancreatic carcinoma | Etiology | Rodents | Genetics | Physiology | Trends | Interleukin 8 | Medical research | Gli1 protein | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Gene expression | Insulin | Signaling | Hypotheses | Hedgehog protein | Aberration | Molecular biology | Human behavior | Cancer | Matrilysin | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 10/2017, Volume 265, pp. 133 - 139
The factor VII activating protease (FSAP) knockout mice have a bigger neointima after vascular injury and a larger infarct volume after stroke. The Marburg I... 
Atherosclerosis | Protease activated receptors | Inflammation | Gene expression | FSAP | Thrombosis | HABP2 | CARDIAC & CARDIOVASCULAR SYSTEMS | RECEPTOR | RISK | NEOINTIMA FORMATION | PROTEOLYSIS | INDUCTION | IL-6 | INTERLEUKIN-6 EXPRESSION | PERIPHERAL VASCULAR DISEASE | MARBURG-I POLYMORPHISM | PROMOTES | Inflammation - pathology | Interleukin-8 - genetics | Receptor, PAR-1 - metabolism | Humans | Apoptosis - genetics | Gene Expression Profiling | Time Factors | Cyclooxygenase 2 - genetics | E-Selectin - genetics | Inflammation Mediators - metabolism | Serine Endopeptidases - genetics | Amphiregulin - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Amphiregulin - genetics | Cell Proliferation - genetics | Interleukin-6 - genetics | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Cells, Cultured | Gene Expression Regulation | E-Selectin - metabolism | Receptor, PAR-1 - genetics | Muscle, Smooth, Vascular - pathology | Human Umbilical Vein Endothelial Cells - enzymology | Cyclooxygenase 2 - metabolism | Inflammation - genetics | Serine Endopeptidases - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Inflammation - enzymology | Muscle, Smooth, Vascular - enzymology | Single nucleotide polymorphisms | Proteases | Genes | Endothelium | Anopheles | Platelet-derived growth factor | Analysis | Genetic research | Smooth muscle | Fibroblast growth factors | Index Medicus
Journal Article
Tumor Biology, ISSN 1010-4283, 7/2016, Volume 37, Issue 7, pp. 9197 - 9207
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2009, Volume 27, Issue 30, pp. 5068 - 5074
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 39, pp. 32578 - 32587
Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host... 
CELLS | ACTIVATION | ALPHA-CONVERTING ENZYME | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENTEROTOXINS | PENETRATION | NECROSIS-FACTOR-ALPHA | CLEAVAGE | EXPRESSION | SYNDECANS | ADAM17 Protein | Interleukin-8 - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Syndecan-1 - genetics | ErbB Receptors - genetics | Glycoproteins - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Amphiregulin | Superantigens - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | EGF Family of Proteins | Bacterial Toxins - genetics | Dipeptides - metabolism | Interleukin-8 - metabolism | Transforming Growth Factor alpha - metabolism | Staphylococcus aureus - metabolism | Glycoproteins - genetics | Staphylococcus aureus - genetics | ErbB Receptors - metabolism | Syndecan-1 - metabolism | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Transforming Growth Factor alpha - genetics | Hydroxamic Acids - metabolism | ADAM Proteins - metabolism | Bacterial Toxins - metabolism | Enterotoxins - genetics | Models, Biological | Superantigens - genetics | Enterotoxins - metabolism | Human Umbilical Vein Endothelial Cells - pathology | ADAM Proteins - genetics | Dipeptides - genetics | Index Medicus | Molecular Bases of Disease | Shedding | Toxic Shock Syndrome | ADAM ADAMTS | Epidermal Growth Factor Receptor (EGFR) | Epithelial Cell | Mucosal Immunology | Superantigen | Staphylococcus aureus
Journal Article
Journal Article
by Chen, Z and Chen, J and Gu, Y and Hu, C and Li, J.-L and Lin, S and Shen, H and Cao, C and Gao, R and Li, J and Ha, P.K and Kaye, F.J and Griffin, J.D and Wu, L
Oncogene, ISSN 0950-9232, 07/2014, Volume 33, Issue 29, pp. 3869 - 3877
Salivary gland tumors (SGT) are a group of highly heterogeneous head and neck malignancies with widely varied clinical outcomes and no standard effective... 
salivary gland tumors | mucoepidermoid carcinoma | AREG | CRTC1-MAML2 | EGFR | WILD-TYPE | TRANSCRIPTIONAL COACTIVATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMORS | CELL BIOLOGY | LUNG-CANCER | CETUXIMAB | ONCOGENE | CREB | ONCOLOGY | GENETICS & HEREDITY | NOTCH RECEPTORS | T(11/19) TRANSLOCATION | MASTERMIND | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Glycoproteins - metabolism | Cell Survival - genetics | Amphiregulin | Carcinoma, Mucoepidermoid - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Carcinoma, Mucoepidermoid - genetics | Receptor, Epidermal Growth Factor - metabolism | Heterografts | EGF Family of Proteins | Antibodies, Monoclonal, Humanized - pharmacology | Female | Cetuximab | Nuclear Proteins - genetics | Disease Models, Animal | Glycoproteins - genetics | Cell Survival - drug effects | Intercellular Signaling Peptides and Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomes, Human, Pair 19 | Animals | Signal Transduction - drug effects | Oncogene Proteins, Fusion - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Cell Line, Tumor | Protein Binding | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Chromosomes, Human, Pair 11 | Salivary gland tumors | Cancer cells | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Cancer | Signal transduction | Head & neck cancer | Cancer therapies | Clinical outcomes | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 50, pp. 41991 - 42000
Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) activation have been described in animal models of pulmonary fibrosis and in patients with... 
APOPTOSIS | TGF-BETA | SIGNALING PATHWAY | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | MYOFIBROBLAST DIFFERENTIATION | INDUCED LUNG FIBROSIS | FACTOR-ALPHA | TRANSGENIC MICE | NIH 3T3 Cells | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Transforming Growth Factor beta1 - metabolism | Intercellular Signaling Peptides and Proteins - biosynthesis | Pulmonary Fibrosis - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Amphiregulin | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Lung - metabolism | Pulmonary Fibrosis - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Fibroblasts - metabolism | Glycoproteins - genetics | Lung - pathology | Gene Expression Regulation - genetics | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Smad Proteins - genetics | Pulmonary Fibrosis - pathology | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Glycoproteins - biosynthesis | Animals | Ligands | Mice | Smad Proteins - metabolism | Index Medicus | Molecular Bases of Disease | Epidermal Growth Factor Receptor (EGFR) | Fibroblast | Lung | Animal Models | Fibrosis
Journal Article
Modern Pathology, ISSN 0893-3952, 2014, Volume 27, Issue 5, pp. 665 - 674
Our objective was to explore alteration of the epidermal growth factor receptor (EGFR) signaling pathway in ampullary carcinoma. lmmunohistochemical studies... 
epidermal growth factor receptor pathway | KRAS | PIK3CA | ampullary carcinoma | TARGETED THERAPY | PIK3CA MUTATIONS | PATHOLOGY | PANCREATIC-CARCINOMA | MOLECULAR ANALYSIS | COLON-CANCER | AMPHIREGULIN | K-RAS | COLORECTAL-CANCER | ONCOGENIC MUTATIONS | PlK3CA | DPC4/SMAD4 GENE | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Humans | Middle Aged | ras Proteins - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | DNA Mutational Analysis | Ampulla of Vater - metabolism | Female | Adenocarcinoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Common Bile Duct Neoplasms - genetics | Duodenal Neoplasms - pathology | Proto-Oncogene Proteins B-raf - metabolism | Ampulla of Vater - pathology | PTEN Phosphohydrolase - genetics | Pancreatic Neoplasms - pathology | Duodenal Neoplasms - genetics | PTEN Phosphohydrolase - metabolism | Pancreatic Neoplasms - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Common Bile Duct Neoplasms - metabolism | Duodenal Neoplasms - metabolism | Signal Transduction - physiology | Aged | Common Bile Duct Neoplasms - pathology | Index Medicus | Ampullary carcinoma | Epidermal growth factor receptor pathway
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2009, Volume 119, Issue 10, pp. 3000 - 3010
EGFR is a major anticancer drug target in human epithelial. tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib... 
MEDICINE, RESEARCH & EXPERIMENTAL | CETUXIMAB | GEFITINIB | FACTOR RECEPTOR MUTATIONS | COMBINATION THERAPY | EPIDERMAL-GROWTH-FACTOR | T790M MUTATIONS | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | GENE MUTATION | ERLOTINIB | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Receptor, Epidermal Growth Factor - genetics | Humans | Glycoproteins - metabolism | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Epiregulin | Amphiregulin | Antibodies, Monoclonal, Humanized | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Quinazolines - metabolism | Tumor Cells, Cultured | Cetuximab | Disease Models, Animal | Glycoproteins - genetics | Lung Neoplasms - genetics | Epidermal Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - genetics | Epidermal Growth Factor - metabolism | Mice, Transgenic | Paclitaxel - therapeutic use | Drug Resistance, Neoplasm - genetics | Animals | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Mice | Mutation | Genetic aspects | Gene mutations | Drug therapy | Drug resistance | Identification and classification | Lung cancer | Index Medicus | Abridged Index Medicus
Journal Article