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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 715 - 718
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2004, Volume 164, Issue 5, pp. 769 - 779
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases.... 
EGF receptor | Growth factor signaling | EGF receptor ligands | ADAMs | Ectodomain shedding | ectodomain shedding | HB-EGF | MEMBRANE | TACE | ALPHA-CONVERTING-ENZYME | growth factor signaling | FACTOR RECEPTOR | MICE LACKING | FAMILY | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | TGF-ALPHA | METALLOPROTEASE-DISINTEGRIN | ADAM17 Protein | Metalloendopeptidases - genetics | Phenylalanine - analogs & derivatives | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Thiophenes - metabolism | Epiregulin | Amphiregulin | Disintegrins - genetics | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Embryo, Mammalian - anatomy & histology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Transforming Growth Factor alpha - metabolism | Fibroblasts - metabolism | Tetradecanoylphorbol Acetate - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Phenylalanine - metabolism | Disintegrins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Epidermal Growth Factor - metabolism | Genotype | Protease Inhibitors - metabolism | ADAM Proteins | Mice, Knockout | Muscle Proteins - genetics | Heparin-binding EGF-like Growth Factor | Animals | Endopeptidases - genetics | Betacellulin | Ligands | Fibroblasts - cytology | Mice | Cytology | Research | EGF receptor; EGF receptor ligands; ADAMs; ectodomain shedding; growth factor signaling
Journal Article
Development, ISSN 0950-1991, 07/2009, Volume 136, Issue 13, pp. 2153 - 2164
A key initial event in hair follicle morphogenesis is the localised thickening of the skin epithelium to form a placode, partitioning future hair follicle... 
Hair follicle | KGF | Mouse | EGF | Skin organ culture | ORGAN-CULTURE | DEVELOPMENTAL BIOLOGY | FACTOR RECEPTOR | MORPHOGENESIS | KERATINOCYTE GROWTH-FACTOR | GENE | LIGANDS | CELL-DIFFERENTIATION | EXPRESSION | SONIC-HEDGEHOG | TRANSGENIC MICE | Receptor, Epidermal Growth Factor - genetics | Cadherins - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Glycoproteins - metabolism | Hedgehog Proteins - metabolism | Quinazolines | Amphiregulin | Wnt Proteins - metabolism | Vibrissae - embryology | Intercellular Signaling Peptides and Proteins - metabolism | Fibroblast Growth Factor 7 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Wnt Proteins - genetics | EGF Family of Proteins | Hedgehog Proteins - genetics | Hyaluronan Receptors - metabolism | Vibrissae - anatomy & histology | Hair Follicle - embryology | Cell Differentiation - physiology | Skin - embryology | Fibroblast Growth Factor 10 - metabolism | Skin - anatomy & histology | Syndecan-1 - metabolism | Enzyme Inhibitors - metabolism | Epidermal Growth Factor - genetics | Tissue Culture Techniques | Mice, Inbred C57BL | Oncogene Proteins - metabolism | Epidermal Growth Factor - metabolism | beta Catenin - metabolism | Fibroblast Growth Factor 7 - genetics | Heparin-binding EGF-like Growth Factor | Hair Follicle - cytology | Animals | Hair Follicle - metabolism | Tyrphostins - metabolism | Epidermis - embryology | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | Zinc Finger Protein GLI1 | Morphogenesis - physiology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Epidermis - cytology
Journal Article
Nature Cell Biology, ISSN 1465-7392, 12/2009, Volume 11, Issue 12, pp. 1444 - 1450
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2003, Volume 22, Issue 10, pp. 2411 - 2421
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0188649
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65403
Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene... 
ACTIVATED PROTEIN-KINASE | PATHWAY | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | DEGRADATION | MECHANISMS | COOPERATION | CANCER | SONIC-HEDGEHOG | Interleukin-8 - genetics | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Hedgehog Proteins - metabolism | Gene Expression Profiling | Vascular Endothelial Growth Factor A - metabolism | Hedgehog Proteins - agonists | Vascular Endothelial Growth Factor A - genetics | Dermis - drug effects | Matrix Metalloproteinase 7 - metabolism | Medulloblastoma - pathology | Biomarkers, Tumor - metabolism | Cerebellar Neoplasms - pathology | Interleukin-8 - metabolism | Patched Receptors | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Cerebellar Neoplasms - metabolism | Fibroblasts - metabolism | Cerebellar Neoplasms - drug therapy | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Medulloblastoma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Fibroblasts - drug effects | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Zinc Finger Protein GLI1 | Patched-1 Receptor | Receptors, Cell Surface - genetics | Receptor, Epidermal Growth Factor - metabolism | Hedgehog Proteins - genetics | Cyclohexylamines - pharmacology | HEK293 Cells | Veratrum Alkaloids - pharmacology | Dermis - cytology | Dermis - metabolism | Enzyme-Linked Immunosorbent Assay | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Matrix Metalloproteinase 7 - genetics | Carrier Proteins - metabolism | Protein Array Analysis | Medulloblastoma - drug therapy | Genetic aspects | Epidermal growth factor | Medulloblastoma | Pancreatic cancer | Genes | Skin cancer | Regulators | Transcription factors | Transcription | Brain cancer | Genomics | Crosstalk | Signal strength | AKT protein | Genomes | Insulin-like growth factors | Amphiregulin | Kinases | Synergism | Proteins | Synergistic effects | Signal transduction | Immunology | Pancreatic carcinoma | Etiology | Rodents | Genetics | Physiology | Trends | Interleukin 8 | Medical research | Gli1 protein | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Gene expression | Insulin | Signaling | Hypotheses | Hedgehog protein | Aberration | Molecular biology | Human behavior | Matrilysin
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 10/2016, Volume 20, Issue 10, pp. 1829 - 1839
Chronic myelogenous leukaemia (CML) is a clonal myeloproliferative disorder. Recent evidence indicates that altered crosstalk between CML and mesenchymal... 
exosomes | epidermal growth factor receptor | chronic myeloid leukaemia | SNAIL | interleukin 8 | MULTIPLE-MYELOMA | TUMOR-STROMA | MEDICINE, RESEARCH & EXPERIMENTAL | CARCINOMA CELLS | ANNEXIN-II | CANCER-CELL INVASION | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | AMPHIREGULIN | EGFR LIGANDS | PROSTATE-CANCER | STROMAL CELLS | Exosomes - metabolism | Phosphorylation | Snail Family Transcription Factors - metabolism | Humans | RNA, Messenger - genetics | Stromal Cells - metabolism | Bone Marrow Cells - pathology | Cellular Microenvironment | RNA, Messenger - metabolism | Cell Adhesion | Matrix Metalloproteinase 9 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Snail Family Transcription Factors - genetics | Matrix Metalloproteinase 9 - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Amphiregulin - metabolism | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Interleukin-8 - metabolism | Annexin A2 - metabolism | Bone Marrow Cells - metabolism | RNA, Small Interfering - metabolism | Epidermal growth factor | Interleukins | Annexins | Gene expression | Analysis | Stem cells | Bone marrow | Leukemia | Cell proliferation | Mesenchyme | Crosstalk | Multiple myeloma | Exosomes | Kinases | Amphiregulin | Blood | Cell adhesion & migration | Proteins | Ethics | Angiogenesis | Cell growth | Penicillin | Growth factors | Interleukin 8 | Enzyme-linked immunosorbent assay | Cell survival | Cytokines | Epidermal growth factor receptors | Invasiveness | Committees | Chronic myeloid leukemia | Secretions | Survival | Myeloproliferative diseases | Gelatinase B | Signaling | Stromal cells | Ligands | Prostate cancer | Tumors | Apoptosis | Original
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 02/2009, Volume 1155, Issue 1, pp. 206 - 221
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2014, Volume 134, Issue 11, pp. 2560 - 2571
To select the appropriate patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs), it is important to gain a better... 
lung cancer | EGFR‐TKI resistance | PI3K‐AKT | sirtuins | IGF1R | EGFR-TKI resistance | PI3K-AKT | CANCER-CELLS | KU70 | APOPTOSIS | RECEPTOR INHIBITION | AKT | HDAC6 | AMPHIREGULIN | ONCOLOGY | POOR-PROGNOSIS | EXPRESSION | HISTONE DEACETYLASE | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Receptor, IGF Type 1 - metabolism | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Prospective Studies | Adenocarcinoma, Mucinous - pathology | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Middle Aged | Drug Resistance, Neoplasm | Male | Immunoenzyme Techniques | Neoplasm Metastasis | Adenocarcinoma - metabolism | Aged, 80 and over | Acetylation | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | bcl-2-Associated X Protein - metabolism | Mutation - genetics | Adenocarcinoma - drug therapy | Blotting, Western | Ku Autoantigen | Mitogen-Activated Protein Kinase 3 - metabolism | Adenocarcinoma, Mucinous - genetics | Quinazolines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | ras Proteins - genetics | Immunoprecipitation | Prognosis | Antigens, Nuclear - metabolism | Lung Neoplasms - pathology | DNA-Binding Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Adult | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Adenocarcinoma, Mucinous - drug therapy | Lung Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Adenocarcinoma, Mucinous - metabolism | Aged | Cell Proliferation - drug effects | Histone Deacetylase 1 - metabolism | Adenocarcinoma | Membrane lipids | Inositol | Epidermal growth factor | Analysis | Lung cancer | Development and progression | Plant lipids | Gefitinib | Mitogens | Kinases | Rodents | Medical prognosis | Tumors | Apoptosis | Life Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 39, pp. 32578 - 32587
Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host... 
CELLS | ACTIVATION | ALPHA-CONVERTING ENZYME | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENTEROTOXINS | PENETRATION | NECROSIS-FACTOR-ALPHA | CLEAVAGE | EXPRESSION | SYNDECANS | ADAM17 Protein | Interleukin-8 - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Syndecan-1 - genetics | ErbB Receptors - genetics | Glycoproteins - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Amphiregulin | Superantigens - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | EGF Family of Proteins | Bacterial Toxins - genetics | Dipeptides - metabolism | Interleukin-8 - metabolism | Transforming Growth Factor alpha - metabolism | Staphylococcus aureus - metabolism | Glycoproteins - genetics | Staphylococcus aureus - genetics | ErbB Receptors - metabolism | Syndecan-1 - metabolism | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Transforming Growth Factor alpha - genetics | Hydroxamic Acids - metabolism | ADAM Proteins - metabolism | Bacterial Toxins - metabolism | Enterotoxins - genetics | Models, Biological | Superantigens - genetics | Enterotoxins - metabolism | Human Umbilical Vein Endothelial Cells - pathology | ADAM Proteins - genetics | Dipeptides - genetics | Molecular Bases of Disease | Shedding | Toxic Shock Syndrome | ADAM ADAMTS | Epidermal Growth Factor Receptor (EGFR) | Epithelial Cell | Mucosal Immunology | Superantigen | Staphylococcus aureus
Journal Article