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Journal of Neuroscience, ISSN 0270-6474, 03/2010, Volume 30, Issue 9, pp. 3326 - 3338
Amyloid-beta(A beta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little... 
OXIDATIVE STRESS | IN-VITRO | SYNAPTIC FUNCTION | GLUCOSE-METABOLISM | ALZHEIMERS-DISEASE | CULTURED ASTROCYTES | SCAVENGER RECEPTORS | GLIAL-CELLS | ASTROGLIAL CELLS | CORTICAL ASTROCYTES | NEUROSCIENCES | Animals, Newborn | Brain | Peptide Fragments | Free Radicals | Oxidative Stress | Astrocytes | Cell Survival | Neurons | Hydrogen Peroxide | Cells, Cultured | Cell Communication | Glucose | Alzheimer Disease | Phosphatidylinositol 3-Kinases | Index Medicus | Phenotype | Animals | Energy Metabolism | Amyloid beta-Peptides | Mice | Nerve Degeneration | Glutathione | Glutathione - metabolism | Peptide Fragments - toxicity | Oxidative Stress - physiology | Nerve Degeneration - physiopathology | Cell Communication - physiology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Nerve Degeneration - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Amyloid beta-Peptides - metabolism | Free Radicals - metabolism | Neurons - metabolism | Energy Metabolism - physiology | Cell Survival - physiology | Astrocytes - drug effects | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Amyloid beta-Peptides - toxicity | Brain - physiopathology | Nerve Degeneration - pathology | Hydrogen Peroxide - metabolism | Alzheimer Disease - metabolism | Cell Communication - drug effects | Brain - pathology | Glucose - metabolism | Oxidative Stress - drug effects | Energy Metabolism - drug effects | Astrocytes - metabolism
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 9/2011, Volume 122, Issue 3, pp. 293 - 311
Cerebrovascular lesions related to congophilic amyloid angiopathy (CAA) often accompany deposition of β-amyloid (Aβ) in Alzheimer’s disease (AD), leading to... 
Pathology | Neurosciences | Congophilic amyloid angiopathy | Medicine & Public Health | Alzheimer’s disease | Astrocytes | Cerebral glucose metabolism | Alzheimer's disease | MICROVASCULAR PATHOLOGY | ALZHEIMERS-DISEASE | NEUROVASCULAR MECHANISMS | GLUCOSE-UTILIZATION | PATHOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | CLINICAL NEUROLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | SMOOTH-MUSCLE-CELLS | RAT-BRAIN | Glucose transporter | Leakage | Brain | Neurodegenerative diseases | Cognitive ability | Transgenic mice | Blood vessels | Data processing | Smooth muscle | beta -Amyloid | Glucose transport | Metabolism | Amyloid precursor protein | Blood-brain barrier | Cerebral blood flow | Lactic acid | Mutation | Microdialysis - methods | Humans | Astrocytes - pathology | Dystroglycans - metabolism | Glucose Transporter Type 1 - metabolism | Muscle, Smooth - ultrastructure | Glial Fibrillary Acidic Protein - metabolism | Microscopy, Electron, Scanning - methods | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Cell Culture Techniques | Disease Models, Animal | Endothelium - pathology | Mice, Transgenic | Cerebral Arteries - ultrastructure | Basement Membrane - metabolism | Disease Progression | Symporters - metabolism | Astrocytes - ultrastructure | Blood-Brain Barrier - pathology | Cerebral Arteries - metabolism | Brain - pathology | Glucose - metabolism | Plaque, Amyloid - metabolism | Mice | Astrocytes - metabolism | Blood-Brain Barrier - physiopathology | Basement Membrane - pathology | Cerebral Amyloid Angiopathy - complications | Monocarboxylic Acid Transporters - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Hemorrhage - etiology | Amyloid beta-Protein Precursor - metabolism | Lactase - metabolism | Cerebral Amyloid Angiopathy - genetics | Astrocytes - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Hemorrhage - metabolism | Muscle, Smooth - metabolism | Cerebrovascular Disorders - etiology | Cerebral Amyloid Angiopathy - pathology | Animals | Endothelium - metabolism | Glucose Transporter Type 1 - genetics | Symporters - genetics | Cerebral Arteries - pathology | Laminin - metabolism | Monocarboxylic Acid Transporters - genetics | Cerebrovascular Disorders - pathology | Hemorrhage - pathology | Muscle, Smooth - pathology | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9677 - 9689
Passive immunization against beta-amyloid (A beta) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD).... 
APP TRANSGENIC MICE | NATURAL OLIGOMERS | HUMAN IGG1 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PASSIVE-IMMUNIZATION | SECRETED OLIGOMERS | P38 MAP KINASE | Edema | Neuroprotection | Apolipoprotein E4 | Neurodegenerative diseases | Cytokines | Immunoglobulin G | Clinical trials | MAP kinase | beta -Amyloid | Inflammation | Neuronal-glial interactions | Microglia | Neurotoxicity | Presenilin 1 | Immunotherapy | Monoclonal antibodies | Immunization (passive) | Alzheimer's disease | Tumor necrosis factor- alpha | Microglia - metabolism | Humans | Middle Aged | Male | Green Fluorescent Proteins - genetics | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Neuroprotective Agents - pharmacology | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Statistics, Nonparametric | Aged, 80 and over | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Alzheimer Disease - immunology | Receptors, Chemokine - genetics | Plaque, Amyloid - immunology | Disease Models, Animal | Animals, Newborn | Rats | Mice, Transgenic | Mutation - genetics | Rats, Sprague-Dawley | Microscopy, Confocal | Plaque, Amyloid - metabolism | Mice | CX3C Chemokine Receptor 1 | Alzheimer Disease - blood | Immunoglobulin G - metabolism | Tumor Necrosis Factor-alpha - metabolism | Dose-Response Relationship, Immunologic | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Immunoglobulin G - pharmacology | Female | Neurons - drug effects | Peptide Fragments - metabolism | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Alzheimer Disease - therapy | Cells, Cultured | Presenilin-1 - genetics | Hippocampus - cytology | Gene Expression Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Peptides - immunology | Aged | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Brain | Cell culture | Flow cytometry | Phosphorylation | Neurodegenerative diseases | Neurons | Fetuses | Glycogen synthase kinase 3 | endosomes | beta -Amyloid | mRNA | Amyloid precursor protein | Tau protein | Proteolysis | Stem cells | Fibroblasts | Alzheimer's disease | Secretase | Inhibitory postsynaptic potentials | Nuclear Reprogramming | Peptide Fragments | Synapsins | Biological Markers | Coculture Techniques | Humans | Middle Aged | Protease Inhibitors | Glycogen Synthase Kinase 3 | Male | Genomes | tau Proteins | Proteins | Efficiency | Phosphoproteins | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides | Female | amyloid beta-protein (1-40) | Astrocytes | Cells, Cultured | Alzheimer Disease | Aged, 80 & over | Models, Biological | Mutation | Enzyme Activation | Alzheimers disease | Induced Pluripotent Stem Cells | Amyloid beta-Protein Precursor | Endosomes | Neurons - pathology | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Messenger RNA | Synthesis | Glycogen | Physiological aspects | Research | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, pp. 10242 - 10242
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains... 
GLUTAMATE NEUROTOXICITY | METABOLIC SYNDROME | INSULIN-DEGRADING ENZYME | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | A-BETA | COGNITIVE IMPAIRMENT | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL FISSION | Dynamins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cerebral Cortex - pathology | Immunoblotting | Male | Metabolic Syndrome - metabolism | Reactive Nitrogen Species | Diabetes Mellitus, Type 2 - metabolism | Cerebral Cortex - cytology | Case-Control Studies | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Nitroso Compounds - metabolism | Synapses - metabolism | Mitochondrial Proteins - metabolism | Dendritic Spines | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Neurons - metabolism | Disease Models, Animal | Insulysin - metabolism | Brain - cytology | Memantine - pharmacology | Oxygen Consumption | Rats | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Hyperglycemia - metabolism | Hippocampus - metabolism | Insulin - metabolism | Animals | GTP Phosphohydrolases - metabolism | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Glucose - metabolism | Aged | Mice | Nitric Oxide - metabolism | Induced Pluripotent Stem Cells | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Brain | Animal models | Multiple sclerosis | Disease | Transcription | Genes | Homeostasis | Sclerosis | Proteins | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | Plaques | Myeloid cells | Neurodegenerative diseases | Amyotrophic lateral sclerosis | Apolipoproteins | Microglia | Neurological diseases | Molecular modelling | β-Amyloid | Phagocytosis | Apoptosis | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Neurons | Analysis | Genetic aspects | Genetic transcription | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
ACTIVATION | MOLECULAR PLATFORM | ASTROGLIAL CULTURES | DISTINCT PATHWAYS | ALZHEIMERS-DISEASE | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | CENTRAL-NERVOUS-SYSTEM | IL-1-BETA | NALP3 INFLAMMASOME | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Alumni | Proteins | Rodents | Luxembourg | Microglial cells | Amyloid | Life sciences | Communication | Cytokines | Neurodegenerative diseases | Inflammasomes | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Immune systems | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Interleukin-1alpha | Peptide Fragments | Enzyme-Linked Immunosorbent Assay | NLR Family, Pyrin Domain-Containing 3 Protein | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta | Mice, Knockout | Index Medicus | Receptors, Purinergic P2X7 | Animals | Amyloid beta-Peptides | Caspase 1 | Mice | Interleukin-18 | Nlrp3 protein, mouse | amyloid beta-protein (25-35) | alpha-Synuclein | Carrier Proteins | Microglia - metabolism | Inflammasomes - metabolism | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Carrier Proteins - genetics | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Interleukin-18 - metabolism | Astrocytes - metabolism | Health aspects | Nervous system diseases
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 23, pp. 5438 - 5458
Abstract Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders. We sought to elucidate possible effects of... 
Advanced Basic Science | Dentistry | Oxidative stress | Mitochondria | Caspase-dependent apoptosis | Endoplasmic reticulum | Alginate oligosaccharide | PC12 cells | SIGNALING PATHWAYS | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CASCADES | P53 | DISEASES | BAX | CYTOCHROME-C RELEASE | PROTEINS | BINDING | MEMBRANE PERMEABILIZATION | Stresses | Surgical implants | Biomedical materials | Cell death | Cascades | Blocking | Activation | Kinases | Nuclear factor-erythroid 2 p45-related factor 2 | Bcl-2 protein | Antioxidant responsive elements | Alginic acid | JNK | oligosaccharides | MDA | H2O2 | MTT | Caspase-3 | Heat shock protein | Alzheimer's disease | Mitogen-activated protein kinases | AREs | c-Jun NH2-terminal kinase | Kelch-like ECH-associated protein 1 | Neurodegenerative diseases | HSP | AO/EB | NF- Kappa B | MAPK | NGF | Malondialdehyde | NF- Kappa B protein | Molecular modelling | A beta | superoxide dismutase | CAT | ROS | ERK | Neuroprotection | Phosphorylation | Advanced glycation end-products | Hydrogen peroxide | Bax protein | glutathione | Amyloid beta | Catalase | nerve growth factor | Nrf2 | reactive oxygen species | Acridine orange/ethidium bromide | 3-[4, 5-dimethylthiazol-2-yl]-2, 5-dephenyl tetrazolium bromide | Nuclear factor- Kappa B | GSH | AOS | Poly(ADP-ribose) polymerase | Extracellular signal-regulated kinase | Data processing | SOD | AGEs | Electrochemiluminescence | p53 protein | ECL | Pheochromocytoma cells | Keap1 | Apoptosis | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Oligosaccharides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Inducing Factor - pharmacology | Cell Nucleus - metabolism | Endoplasmic Reticulum - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Glucuronic Acid - chemistry | Neurons - drug effects | Polysaccharide-Lyases - chemistry | Apoptosis Inducing Factor - metabolism | Cell Survival - drug effects | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Hexuronic Acids - chemistry | Mitochondria - drug effects | HSP70 Heat-Shock Proteins - metabolism | Cell Shape - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Alginates - chemistry | NF-E2-Related Factor 2 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Apoptosis - physiology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Neurosciences | Nervous system diseases | Biological products | Heat shock proteins | Nerve growth factor | Superoxide | Mitochondrial DNA | Biochemistry | Antioxidants | Tumor proteins | Protein kinases | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 39, pp. 13454 - 13469
Abnormal deposition and intercellular propagation of alpha-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and... 
IMMUNIZATION | FC-GAMMA RECEPTORS | HUMAN PLASMA | ALZHEIMERS-DISEASE | MOUSE MODEL | CENTRAL-NERVOUS-SYSTEM | MICE | PATHOLOGY | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PARKINSONS-DISEASE | Brain | Animal models | Parkinson's disease | Neurodegenerative diseases | Astrocytes | Antibodies | Nervous system | Synuclein | Neuronal-glial interactions | Microglia | Lewy bodies | Fc receptors | Disease transmission | Neurodegeneration | Immunotherapy | Dementia disorders | Immunization (passive) | Movement disorders | Synaptic Transmission - physiology | Antibodies - metabolism | Lewy Body Disease - immunology | Humans | alpha-Synuclein - immunology | Extracellular Space - drug effects | Nerve Degeneration - genetics | Cell Communication - physiology | Culture Media, Conditioned - pharmacology | Phosphopyruvate Hydratase - metabolism | Amyloid - ultrastructure | Antigens, CD - metabolism | Neuroglia - drug effects | Brain - metabolism | Lewy Body Disease - genetics | Extracellular Space - metabolism | Amyloid - metabolism | Microfilament Proteins - metabolism | alpha-Synuclein - genetics | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cell Line | Microscopy, Electron, Transmission | Cytokines - metabolism | Mice, Transgenic | Nerve Degeneration - immunology | Cathepsin D - metabolism | Extracellular Space - immunology | Antibodies - pharmacology | Caveolin 1 - metabolism | Lewy Body Disease - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Analysis of Variance | Brain - pathology | Immunization, Passive | Neuroglia - metabolism | Mice | Chromatography, Gel | alpha-Synuclein - metabolism | Nerve Degeneration - drug therapy | Astrocytes - metabolism | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 07/2010, Volume 277, Issue 14, pp. 3051 - 3067
The cognitive impairment in patients with Alzheimer's disease is closely associated with synaptic loss in the neocortex and limbic system. Although the... 
amyloid | PSD95 | Shank | Alzheimer's disease | oligomers | BIOCHEMISTRY & MOLECULAR BIOLOGY | COGNITIVE IMPAIRMENT | DELETION SYNDROME | DENDRITIC SPINES | GLUTAMATE RECEPTORS | POSTSYNAPTIC DENSITY PROTEINS | SOLUBLE BETA-AMYLOID(1-40) | A-BETA | LONG-TERM POTENTIATION | NMDA RECEPTOR SUBUNITS | SECRETED OLIGOMERS | Subpopulations | Brain | Animal models | Neurodegenerative diseases | Transgenic mice | Cortex | Cognitive ability | beta -Amyloid | Limbic system | Amyloid precursor protein | Neurotoxicity | scaffolds | Cortex (frontal) | Synaptic vesicles | Cell Membrane | Peptide Fragments | SHANK1 protein, mouse | Humans | Protein Multimerization | Cerebral Cortex | Male | Cytosol | Dlgh4 protein, mouse | Dendritic Spines | Amyloid beta-Peptides | Aged, 80 and over | Female | Mice, Inbred DBA | Synaptosomal-Associated Protein 25 | Carrier Proteins | Vesicle-Associated Membrane Protein 2 | Shank3 protein, mouse | Neurons | Mice, Inbred C57BL | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Mice, Transgenic | SHANK3 protein, human | Nerve Tissue Proteins | Alzheimer Disease | DLG4 protein, human | Index Medicus | Membrane Proteins | Animals | Guanylate Kinases | Qa-SNARE Proteins | Protein Binding | Aged | Mice | Amyloid beta-Protein Precursor | Synapses | Dementia | Disks Large Homolog 4 Protein | Amyloid beta-Peptides - pharmacology | Cerebral Cortex - pathology | Dendritic Spines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Brain - metabolism | Dementia - metabolism | Synapses - metabolism | Protein Multimerization - physiology | Amyloid beta-Peptides - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Peptide Fragments - genetics | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Carrier Proteins - metabolism | Qa-SNARE Proteins - metabolism | Alzheimer Disease - metabolism | Brain - pathology | Cytosol - metabolism | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Protein Binding - physiology
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Journal Article