X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (19647) 19647
Book Review (4329) 4329
Publication (2055) 2055
Newsletter (1781) 1781
Book Chapter (216) 216
Conference Proceeding (75) 75
Dissertation (38) 38
Book / eBook (17) 17
Magazine Article (15) 15
Newspaper Article (14) 14
Data Set (5) 5
Web Resource (3) 3
Transcript (2) 2
Paper (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (14478) 14478
alzheimer's disease (11419) 11419
humans (10919) 10919
animals (9336) 9336
amyloid precursor protein (6457) 6457
neurosciences (6375) 6375
alzheimers-disease (5738) 5738
mice (4954) 4954
amyloid beta-protein (4863) 4863
biochemistry & molecular biology (4078) 4078
alzheimer disease - metabolism (3835) 3835
amyloid beta-peptides - metabolism (3758) 3758
amyloid beta-protein precursor - metabolism (3137) 3137
amyloid precursor protein secretases - metabolism (3125) 3125
brain (2761) 2761
male (2600) 2600
cell biology (2485) 2485
research (2460) 2460
proteins (2372) 2372
alzheimer disease - pathology (2312) 2312
alzheimer’s disease (2271) 2271
alzheimer disease - genetics (2219) 2219
alzheimers disease (2175) 2175
female (2094) 2094
neurology (2060) 2060
a-beta (2037) 2037
mice, transgenic (1998) 1998
amyloid beta-protein precursor - genetics (1983) 1983
transgenic mice (1931) 1931
disease models, animal (1889) 1889
brain - metabolism (1836) 1836
alzheimer disease - drug therapy (1817) 1817
neurodegenerative diseases (1792) 1792
amyloid precursor protein secretases - antagonists & inhibitors (1742) 1742
oxidative stress (1728) 1728
peptides (1714) 1714
gamma-secretase (1683) 1683
analysis (1643) 1643
in-vivo (1630) 1630
rats (1578) 1578
neurons (1568) 1568
amyloid (1562) 1562
amyloid precursor protein secretases (1559) 1559
precursor protein (1547) 1547
mutation (1444) 1444
expression (1429) 1429
neurons - metabolism (1429) 1429
article (1393) 1393
cells, cultured (1387) 1387
physiological aspects (1379) 1379
neurodegeneration (1369) 1369
membrane proteins - metabolism (1356) 1356
clinical neurology (1351) 1351
mouse model (1345) 1345
pharmacology & pharmacy (1327) 1327
amyloid-beta (1321) 1321
dementia (1289) 1289
cell line (1283) 1283
β-amyloid (1283) 1283
pathology (1277) 1277
peptide fragments - metabolism (1240) 1240
aspartic acid endopeptidases - metabolism (1234) 1234
medical research (1222) 1222
secretase (1194) 1194
amyloid precursor protein secretases - genetics (1189) 1189
alzheimer disease (1182) 1182
cell line, tumor (1151) 1151
apoptosis (1149) 1149
aged (1141) 1141
enzymes (1140) 1140
alzheimer disease - physiopathology (1136) 1136
app (1131) 1131
beta-secretase (1114) 1114
signal transduction (1105) 1105
mice, inbred c57bl (1089) 1089
brain - pathology (1082) 1082
mental disorders (1081) 1081
rodents (1052) 1052
phosphorylation (1048) 1048
presenilin-1 (1015) 1015
multidisciplinary sciences (1010) 1010
cleavage (1005) 1005
genetic aspects (998) 998
membrane proteins - genetics (984) 984
medicine, experimental (981) 981
endopeptidases - metabolism (946) 946
peptide (934) 934
amino acid sequence (912) 912
cells (912) 912
protein (891) 891
gene expression (886) 886
aspartic acid endopeptidases (879) 879
mild cognitive impairment (878) 878
protein binding (877) 877
presenilin (876) 876
molecular sequence data (874) 874
research article (867) 867
health aspects (857) 857
tau (848) 848
memory (847) 847
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21404) 21404
Chinese (80) 80
Japanese (73) 73
French (22) 22
German (16) 16
Spanish (15) 15
Korean (8) 8
Polish (8) 8
Russian (6) 6
Hungarian (5) 5
Corsican (1) 1
Dutch (1) 1
Hebrew (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Brain Research, ISSN 0006-8993, 2014, Volume 1560, pp. 73 - 82
Abstract Amyloid-β (Aβ) is produced through the enzymatic cleavage of amyloid precursor protein (APP) by β (Bace1) and γ-secretases. The accumulation and... 
Neurology | Amyloid-β | Spinal cord injury | Amyloid precursor protein | γ-Secretase | Bace1 | BETA-SECRETASE | MULTIPLE-SCLEROSIS LESIONS | INFLAMMATORY RESPONSES | PERIPHERAL NERVOUS-SYSTEM | ALZHEIMERS-DISEASE | NEUROSCIENCES | LONG-TERM ACCUMULATION | gamma-Secretase | TRAUMATIC BRAIN-INJURY | A-BETA | MICE | TRANSGENIC MOUSE MODEL | Amyloid-beta | Amyloid Precursor Protein Secretases - genetics | Motor Activity - physiology | Spinal Cord - drug effects | Spinal Cord - metabolism | Spinal Cord Injuries - drug therapy | Recovery of Function - drug effects | Motor Activity - drug effects | Aspartic Acid Endopeptidases - genetics | Spinal Cord Injuries - pathology | Presenilin-1 - antagonists & inhibitors | Microglia - physiology | Time Factors | Nerve Fibers, Myelinated - pathology | Spinal Cord - pathology | Amyloid beta-Protein Precursor - metabolism | Recovery of Function - physiology | Nerve Fibers, Myelinated - metabolism | Enzyme-Linked Immunosorbent Assay | Spinal Cord Injuries - metabolism | Mice, Inbred C57BL | Nerve Fibers, Myelinated - drug effects | Enzyme Inhibitors - pharmacology | Blotting, Western | Mice, Knockout | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Presenilin-1 - metabolism | Fluorescent Antibody Technique | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Brain | Enzymes | Nervous system diseases | Multiple sclerosis | Amyloid beta-protein | Spinal cord injuries | Alzheimer's disease | Injuries | Index Medicus | amyloid-β | γ-secretase
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 166 - 170
The gamma-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important... 
PRESENILIN | COMPLEX | PARTICLE ELECTRON CRYOMICROSCOPY | TRANSMEMBRANE DOMAIN-4 | MEMBRANE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NICASTRIN | CRYO-EM | FAMILY INTRAMEMBRANE PROTEASE | BINDING | Cryoelectron Microscopy | Protein Structure, Tertiary | Models, Molecular | Crystallography, X-Ray | Amyloid Precursor Protein Secretases - chemistry | Humans | Index Medicus
Journal Article