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Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 5, pp. 623 - 630
Abstract Given the complex neuropathology Alzheimer's disease (AD), combination therapy may be necessary for effective treatment. However, scientific,... 
Neurology | TRIALS | MODEL | SOLANEZUMAB | CLINICAL NEUROLOGY | HYPOTHESIS | Alzheimer Disease - drug therapy | Amyloid Precursor Protein Secretases - administration & dosage | Alzheimer Disease - physiopathology | Drug Therapy, Combination | Humans | Drug Evaluation | Medical colleges | Neurosciences | Drug therapy | Alzheimer's disease | Index Medicus
Journal Article
Human Gene Therapy, ISSN 1043-0342, 02/2016, Volume 27, Issue 2, pp. 1 - 107
Key neuropathological hallmarks of Alzheimer's disease (AD) are extracellular amyloid plaques and intracellular accumulation of hyperphosphorylated Tau... 
Reviews | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | CHOLESTEROL | NEUROTROPHIC FACTOR | APPS-ALPHA | APOLIPOPROTEIN-E | DELIVERY | BACE1 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMYLOID-BETA | MOUSE MODEL | GENETICS & HEREDITY | BRAIN | Apolipoproteins E - administration & dosage | Amyloid Precursor Protein Secretases - genetics | Brain-Derived Neurotrophic Factor - genetics | RNA, Small Interfering - genetics | Humans | Aspartic Acid Endopeptidases - genetics | Alzheimer Disease - pathology | Brain - metabolism | Somatomedins - administration & dosage | Antibodies, Neutralizing - therapeutic use | Amyloid Precursor Protein Secretases - administration & dosage | Plaque, Amyloid - therapy | Lentivirus - genetics | NF-E2-Related Factor 2 - genetics | Disease Models, Animal | Plaque, Amyloid - pathology | Aspartic Acid Endopeptidases - administration & dosage | Alzheimer Disease - therapy | Clinical Trials as Topic | Disease Progression | NF-E2-Related Factor 2 - administration & dosage | Plaque, Amyloid - genetics | Brain-Derived Neurotrophic Factor - administration & dosage | Animals | Apolipoproteins E - genetics | Somatomedins - genetics | Brain - pathology | Alzheimer Disease - genetics | RNA, Small Interfering - administration & dosage | Genetic Therapy - methods | Proteins | Brain | Animal models | Neurodegenerative diseases | Tau protein | Neuropathology | Therapeutic applications | Amyloid | Gene therapy | Alzheimers disease | Alzheimer's disease | Plaques | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 628, Issue 1, pp. 108 - 115
Alzheimer's disease is a chronic neurodegenerative disorder marked by a progressive loss of memory and cognitive function. Stress level glucocorticoids are... 
Dexamethasone | Memory and learning impairment | Alzheimer's disease | Amyloid precursor protein | Apoptosis | ALZHEIMERS-DISEASE | MODEL | BETA-SECRETASE PROTEIN | HIPPOCAMPUS | PATHOGENESIS | PRESENILINS | PHARMACOLOGY & PHARMACY | MEDIATORS | STRESS | PITUITARY-ADRENAL AXIS | Alzheimer Disease - etiology | Amyloid Precursor Protein Secretases - genetics | Neurons - pathology | Caspase 9 - genetics | Caspase 9 - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Cerebral Cortex - pathology | Memory Disorders - metabolism | Male | Hippocampus - drug effects | RNA, Messenger - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Learning Disorders - pathology | Dexamethasone - pharmacology | Amyloid beta-Protein Precursor - metabolism | Caspase 3 - genetics | Behavior, Animal - drug effects | Cerebral Cortex - drug effects | Neurons - drug effects | Memory Disorders - pathology | RNA, Messenger - genetics | Alzheimer Disease - drug therapy | Hippocampus - pathology | Gene Expression Regulation - drug effects | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Learning Disorders - chemically induced | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease - metabolism | Glucocorticoids - pharmacology | Learning Disorders - metabolism | Mice | Stress, Psychological - complications | Memory Disorders - chemically induced | Immunohistochemistry | Glucocorticoids | Neurodegenerative diseases | Neurons | Memory | Cognitive ability | Cortex | mRNA | Caspase-3 | Stress | Cytochrome c | Learning | Dementia disorders | Hippocampus | Secretase | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2006, Volume 96, Issue 2, pp. 533 - 540
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2009, Volume 15, Issue 1, pp. 50 - 58
Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL).... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | CYCLE ARREST | SRG3 | CELL BIOLOGY | NOTCH1 CONFERS | GOBLET CELLS | GENE | LINE | DIFFERENTIATION | PROMOTER | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Cyclins - genetics | Receptors, Glucocorticoid - metabolism | Cyclin D2 | Enzyme Inhibitors - administration & dosage | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Female | Homeostasis - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - administration & dosage | Membrane Proteins - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mice, SCID | Mice, Knockout | Dexamethasone - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Homeostasis - physiology | Proto-Oncogene Proteins - physiology | Receptors, Glucocorticoid - genetics | Apoptosis Regulatory Proteins - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Receptors, Glucocorticoid - physiology | Receptor, Notch1 - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0151147 - e0151147
Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used... 
CASCADE HYPOTHESIS | PRECURSOR PROTEIN TRAFFICKING | TARGET-DIRECTED LIGANDS | WATER-MAZE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GAMMA-SECRETASE CLEAVAGE | TRANSMEMBRANE DOMAIN | THERAPEUTIC STRATEGIES | Cell Line | Alzheimer Disease - physiopathology | Triterpenes - pharmacology | Medicine, Chinese Traditional | Amyloid beta-Peptides - biosynthesis | Humans | Alzheimer Disease - drug therapy | Drugs, Chinese Herbal - pharmacology | Substrate Specificity | Cognition Disorders - metabolism | Mice, Transgenic | Cognition Disorders - drug therapy | Enzyme Activation - drug effects | Proteolysis - drug effects | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Mice | Nootropic Agents - pharmacology | Disease Models, Animal | Saponins - pharmacology | Pathogenesis | Memory | Cognitive ability | Biochemistry | Biology | Autophagy | Cell adhesion & migration | Proteins | Learning | Constituents | Chinese medicine | Neurodegeneration | Precursors | Rodents | Alzheimer's disease | Age | Pharmaceutical sciences | Medical research | b-Site APP cleaving enzyme 1 | Oral administration | Traditional Chinese medicine | Pharmacology | Chemical compounds | Amyloid precursor protein | Herbal medicine | Medicine | Hypotheses | Brain research | Natural products | Presenilin 1 | Pharmacy | β-Amyloid | Ligands | Cognitive enhancement | Laboratory animals | Alzheimers disease | Secretase | Animal cognition | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 259 - 273
Journal Article