X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (6611) 6611
Newsletter (21) 21
Book Chapter (11) 11
Magazine Article (4) 4
Book / eBook (2) 2
Dissertation (1) 1
Publication (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (4281) 4281
humans (3697) 3697
alzheimer's disease (3508) 3508
neurosciences (2506) 2506
amyloid beta-peptides - metabolism (2428) 2428
alzheimers-disease (2346) 2346
mice (1861) 1861
amyloid beta-peptides - antagonists & inhibitors (1758) 1758
alzheimer disease - metabolism (1686) 1686
alzheimer disease - drug therapy (1545) 1545
rats (1498) 1498
biochemistry & molecular biology (1268) 1268
male (1210) 1210
alzheimer’s disease (1087) 1087
brain (999) 999
alzheimer disease - pathology (979) 979
cells, cultured (957) 957
amyloid precursor protein (909) 909
amyloid beta-peptides - toxicity (896) 896
neurons - drug effects (878) 878
a-beta (852) 852
neurology (846) 846
disease models, animal (840) 840
oxidative stress (831) 831
mice, transgenic (803) 803
neurons - metabolism (783) 783
neurodegenerative diseases (761) 761
peptide fragments - metabolism (752) 752
proteins (744) 744
alzheimers disease (738) 738
peptide fragments - antagonists & inhibitors (724) 724
pharmacology & pharmacy (710) 710
cell biology (696) 696
brain - metabolism (683) 683
neuroprotective agents - pharmacology (657) 657
peptides (641) 641
mouse model (631) 631
amyloid-beta (620) 620
female (618) 618
neurons (613) 613
amyloid beta-protein (610) 610
amyloid beta-protein precursor - metabolism (601) 601
transgenic mice (592) 592
β-amyloid (592) 592
amyloid precursor protein secretases - antagonists & inhibitors (591) 591
amyloid beta-peptides - pharmacology (586) 586
dose-response relationship, drug (579) 579
alzheimer disease - physiopathology (568) 568
neurodegeneration (563) 563
apoptosis (559) 559
peptide fragments - toxicity (555) 555
amyloid (536) 536
amyloid beta-peptides - chemistry (521) 521
protein (520) 520
mice, inbred c57bl (519) 519
precursor protein (512) 512
chemistry, medicinal (497) 497
neurotoxicity (497) 497
peptide (494) 494
alzheimer disease - genetics (489) 489
amyloid precursor protein secretases - metabolism (487) 487
cell survival - drug effects (486) 486
in-vivo (476) 476
memory (460) 460
peptide fragments - pharmacology (458) 458
rats, sprague-dawley (458) 458
dementia (457) 457
inflammation (456) 456
enzyme inhibitors - pharmacology (449) 449
phosphorylation (443) 443
cell line, tumor (437) 437
analysis (433) 433
research (433) 433
in-vitro (431) 431
long-term potentiation (429) 429
hippocampus - drug effects (428) 428
cell line (427) 427
neuroprotection (423) 423
amyloid beta-protein precursor - genetics (422) 422
pathology (412) 412
rodents (410) 410
hippocampus - metabolism (404) 404
beta-amyloid (403) 403
brain - drug effects (399) 399
expression (394) 394
clinical neurology (387) 387
hippocampus (378) 378
activation (375) 375
tau proteins - metabolism (373) 373
biomedicine (370) 370
brain - pathology (369) 369
structure-activity relationship (365) 365
alzheimer disease (359) 359
multidisciplinary sciences (353) 353
pc12 cells (351) 351
disease (347) 347
rats, wistar (341) 341
cognitive ability (333) 333
neurons - pathology (331) 331
signal transduction (330) 330
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6593) 6593
Japanese (52) 52
Chinese (37) 37
German (21) 21
Russian (12) 12
French (5) 5
Portuguese (3) 3
Spanish (2) 2
Danish (1) 1
Dutch (1) 1
Hungarian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
The New England journal of medicine, ISSN 1533-4406, 2014, Volume 370, Issue 4, pp. 322 - 333
In two phase 3 trials in patients with Alzheimer's disease, bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, did not improve clinical outcomes.... 
ANTIBODIES | MEDICINE, GENERAL & INTERNAL | EPITOPE | IMAGING ABNORMALITIES | PEPTIDE | MOUSE MODEL | Phosphorylation | Humans | Middle Aged | Male | Positron-Emission Tomography | Treatment Failure | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Female | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Biomarkers - analysis | Alzheimer Disease - drug therapy | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Cognition - drug effects | Neuropsychological Tests | Amyloid beta-Peptides - antagonists & inhibitors | Apolipoproteins E - genetics | Intention to Treat Analysis | Amyloid beta-Peptides - analysis | Brain - pathology | Aged | Biomarkers - cerebrospinal fluid | Edema - chemically induced | Alzheimer Disease - genetics | Monoclonal antibodies | Product development | Research | Drug therapy | Alzheimer's disease | Health aspects | Edema | Nuclear magnetic resonance--NMR | Intravenous administration | Neurodegenerative diseases | Cognitive ability | Clinical trials | Cerebrospinal fluid | Patients | Studies | Tau protein | Apolipoprotein E | Immunotherapy | Alleles | Dementia disorders | Alzheimers disease | Brain | Neurosciences | pathology | Biological Markers | Antibodies | Cognition | tau Proteins | 80 and over | genetics | Amyloid beta-Peptides | Apolipoproteins E | Monoclonal | Neurovetenskaper | drug therapy | chemically induced | Humanized | drug effects | Alzheimer Disease | analysis | antagonists & inhibitors | cerebrospinal fluid | adverse effects | therapeutic use
Journal Article
Journal Article
Acta pharmacologica Sinica, ISSN 1671-4083, 2017, Volume 38, Issue 9, pp. 1205 - 1235
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and y-secretases. Aβ... 
治疗 | 阿尔茨海默氏病 | 蛋白酶抑制剂 | 淀粉样前体蛋白 | 结构生物学 | microRNA | 阿尔茨海默病 | β-淀粉样蛋白 | neurodegenerative diseases | Amyloid beta peptide | drug discovery | amyloid precursor protein | Alzheimer's disease | PEPTIDE A-BETA | GAMMA-SECRETASE CLEAVAGE | METABOTROPIC GLUTAMATE RECEPTORS | BLOOD-BRAIN-BARRIER | D-ASPARTATE RECEPTOR | CHEMISTRY, MULTIDISCIPLINARY | amyloid beta peptide | AMELIORATES MEMORY IMPAIRMENT | ONSET ALZHEIMERS-DISEASE | NICOTINIC ACETYLCHOLINE-RECEPTOR | PHARMACOLOGY & PHARMACY | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | Small Molecule Libraries - pharmacology | Antibodies - metabolism | Antibodies - chemistry | Humans | Alzheimer Disease - drug therapy | Small Molecule Libraries - chemistry | Vaccines - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Vaccines - chemistry | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Protein Conformation | Amyloid beta-Peptides - chemistry | Drugs | Brain | Pathogenesis | Antibodies | Vaccines | Neuromodulation | Modulators | Proteins | Neurotoxicity | Receptors | Proteolysis | Dementia disorders | miRNA | Plaques | Neurodegenerative diseases | Metabolism | Amyloid precursor protein | Inhibitors | Protease inhibitors | Tau protein | β-Amyloid | Alzheimers disease | Secretase | Dementia | Index Medicus | Review
Journal Article