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1. Full Text α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells
by Kazmierczak, Anna and Strosznajder, Joanna B and Adamczyk, Agata
Neurochemistry international, ISSN 0197-0186, 2008, Volume 53, Issue 6, pp. 263 - 269
α-Synuclein | Programmed cell death | Amyloid beta | Nitric oxide | PC12 cells | ACTIVATED PROTEIN-KINASE | ALZHEIMERS-DISEASE | MULTIPLE SYSTEM | CEREBROSPINAL-FLUID | UMCG Approved | A-BETA | NITRIC-OXIDE | HYDROGEN-PEROXIDE | PRECURSOR PROTEIN | LEWY-BODY-DISEASE | alpha-Synuclein | PARKINSONS-DISEASE | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Biological and medical sciences | Apoptosis - drug effects | Amyloid beta-Peptides - secretion | PC12 Cells | Brain - metabolism | Transfection | Bodily Secretions - physiology | Up-Regulation - physiology | Neurons - secretion | Neurons - metabolism | Neurons - drug effects | Cell Survival - physiology | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Amyloid beta-Peptides - toxicity | alpha-Synuclein - toxicity | Brain - physiopathology | Enzyme Inhibitors - pharmacology | Rats | Drug Synergism | Up-Regulation - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Nitric Oxide Synthase Type I - metabolism | Alzheimer Disease - metabolism | Bodily Secretions - drug effects | Apoptosis - physiology | Nitric Oxide - metabolism | Nitric Oxide Synthase Type I - drug effects | Amyloid beta-Peptides - agonists | alpha-Synuclein - metabolism | Index Medicus
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2. Full Text Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia
by Yuyama, Kohei and Sun, Hui and Mitsutake, Susumu and Igarashi, Yasuyuki
The Journal of biological chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 14, pp. 10977 - 10989
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Microglia - cytology | Microglia - metabolism | Up-Regulation | Protein Structure, Secondary | Phosphatidylserines - metabolism | Protein Multimerization | Amyloid beta-Peptides - secretion | Neurons - cytology | Sphingolipids - metabolism | Animals | Amyloid beta-Peptides - metabolism | Cell Line, Tumor | Mice | Neurons - metabolism | Amyloid beta-Peptides - chemistry | Exosomes - secretion | Index Medicus | Neurons | Neurobiology | Sphingolipid | Alzheimer Disease | Exosomes | Microglia | Amyloid-beta
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3. Full Text Sialylation enhances the secretion of neurotoxic amyloid‐β peptides
by Nakagawa, Kazuhiro and Kitazume, Shinobu and Oka, Ritsuko and Maruyama, Kei and Saido, Takaomi C and Sato, Yuji and Endo, Tamao and Hashimoto, Yasuhiro
Journal of neurochemistry, ISSN 0022-3042, 02/2006, Volume 96, Issue 4, pp. 924 - 933
sialylation | β‐galactoside α2, 6‐sialyltransferase | amyloid precursor protein | amyloid‐beta | β-galactoside α2 | 6-sialyltransferase | Sialylation | Amyloid precursor protein | Amyloid-beta | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Adrenomedullary hormones. Regulation | Neurology | Vertebrates: endocrinology | Adrenals. Interrenals | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Medical sciences | Recombinant Proteins - metabolism | Cell Line | Endopeptidases - metabolism | Cricetinae | Amyloid beta-Peptides - toxicity | Rats | Sialyltransferases - metabolism | Amyloid beta-Protein Precursor - toxicity | Animals | Endopeptidases - genetics | Transfection | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Kinetics | Neurons - drug effects | CHO Cells | Index Medicus
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4. Full Text Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ
by Agholme, Lotta and Clarin, Marcus and Gkanatsiou, Eleni and Kettunen, Petronella and Chebli, Jasmine and Brinkmalm, Gunnar and Blennow, Kaj and Bergström, Petra and Portelius, Erik and Zetterberg, Henrik and Sahlgrenska akademin and Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry and Sahlgrenska Academy
Molecular and cellular neurosciences, ISSN 1044-7431, 12/2017, Volume 85, pp. 211 - 219
Oligomers | Amyloid-β | γ-secretase | Duolink | Neurons | DAPT | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cell Line | Humans | Amyloid beta-Peptides - secretion | Diamines - pharmacology | Neurons - metabolism | Thiazoles - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Neurons - drug effects | Index Medicus | Neurovetenskaper
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5. Full Text Aβ Secretion and Plaque Formation Depend on Autophagy
by Nilsson, Per and Loganathan, Krishnapriya and Sekiguchi, Misaki and Matsuba, Yukio and Hui, Kelvin and Tsubuki, Satoshi and Tanaka, Motomasa and Iwata, Nobuhisa and Saito, Takashi and Saido, Takaomi C
Cell reports (Cambridge), ISSN 2211-1247, 10/2013, Volume 5, Issue 1, pp. 61 - 69
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunohistochemistry | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | Amyloid beta-Peptides - secretion | Mice, Transgenic | Autophagy - physiology | Alzheimer Disease - pathology | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Plaque, Amyloid - metabolism | Mice | Disease Models, Animal | Index Medicus | Medicin och hälsovetenskap
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6. Full Text The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes
by Dal Prà, Ilaria and Armato, Ubaldo and Chioffi, Franco and Pacchiana, Raffaella and Whitfield, James F and Chakravarthy, Balu and Gui, Li and Chiarini, Anna
Neuromolecular medicine, ISSN 1535-1084, 12/2014, Volume 16, Issue 4, pp. 645 - 657
Neurology | Human adult | Calcimimetic | Vascular endothelial growth factor-A | Neurosciences | Biomedicine | Internal Medicine | Amyloid-β | Astrocyte | Calcilytic | Calcium-sensing receptor | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Vascular Endothelial Growth Factor A - biosynthesis | Allosteric Regulation | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Vascular Endothelial Growth Factor A - genetics | Phenethylamines | Vascular Endothelial Growth Factor A - secretion | Adult | Neurons - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Receptors, Calcium-Sensing - antagonists & inhibitors | Astrocytes - drug effects | Receptors, Calcium-Sensing - physiology | Aniline Compounds - pharmacology | Calcium - agonists | Cells, Cultured | Cell Communication | Naphthalenes - pharmacology | Nitric Oxide - secretion | Alzheimer Disease - metabolism | Protein Binding | Temporal Lobe - cytology | Astrocytes - metabolism | Astrocytes - secretion | Propylamines | Index Medicus
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7. Full Text Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
by Cirrito, John R and Kang, Jae-Eun and Lee, Jiyeon and Stewart, Floy R and Verges, Deborah K and Silverio, Luz M and Bu, Guojun and Mennerick, Steven and Holtzman, David M
Neuron (Cambridge, Mass.), ISSN 0896-6273, 04/2008, Volume 58, Issue 1, pp. 42 - 51
SYSNEURO | PROTEINS | HUMDISEASE | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Alzheimer Disease - etiology | Amyloid beta-Peptides - physiology | Alzheimer Disease - physiopathology | Synapses - secretion | Synaptic Transmission - genetics | Mice, Inbred C57BL | Amyloid beta-Peptides - secretion | Mice, Transgenic | Synapses - genetics | Animals | Synapses - metabolism | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Endocytosis - genetics | Mice | Index Medicus
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8. Full Text Lycopene attenuates Aβ1–42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease
by Chen, Wei and Mao, Liuqun and Xing, Huanhuan and Xu, Lei and Fu, Xiang and Huang, Liyingzi and Huang, Dongling and Pu, Zhijun and Li, Qinghua
Neuroscience letters, ISSN 0304-3940, 11/2015, Volume 608, pp. 28 - 33
APP | Caenorhabditis elegans | Alzheimer disease | Aβ1–42 | Lycopene | Cell Survival - drug effects | Peptide Fragments - metabolism | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - toxicity | Apoptosis - drug effects | Peptide Fragments - toxicity | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - secretion | Carotenoids - pharmacology | Alzheimer Disease - pathology | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Carotenoids - metabolism | Cell Line, Tumor | Mutation | Oxidative Stress - drug effects | Index Medicus
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9. Full Text Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A beta(1-42) secretion in SH-SY5Y neural cells
by Khan, Mahfuz B and Lang, Michelle J and Huang, Ming-Bo and Raymond, Andrea and Bond, Vincent C and Shiramizu, Bruce and Powell, Michael D
Journal of neurovirology, ISSN 1355-0284, 04/2016, Volume 22, Issue 2, pp. 179 - 190
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Virology | Neurons - pathology | Humans | Middle Aged | Amyloid beta-Peptides - secretion | Exosomes - pathology | Male | RNA, Viral - blood | Viral Load | RNA, Messenger - biosynthesis | HIV-1 - physiology | Amyloid beta-Peptides - genetics | HEK293 Cells | nef Gene Products, Human Immunodeficiency Virus - metabolism | Adult | Anti-HIV Agents - therapeutic use | Female | Neurons - metabolism | AIDS Dementia Complex - virology | Peptide Fragments - genetics | Exosomes - secretion | AIDS Dementia Complex - physiopathology | HIV-1 - drug effects | AIDS Dementia Complex - blood | AIDS Dementia Complex - drug therapy | Amyloid beta-Peptides - biosynthesis | RNA, Messenger - genetics | RNA, Messenger - secretion | Gene Expression Regulation | Peptide Fragments - secretion | Peptide Fragments - biosynthesis | nef Gene Products, Human Immunodeficiency Virus - genetics | Cell Line, Tumor | Aged | Index Medicus
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10. Full Text Hypoxic enhancement of quantal catecholamine secretion. Evidence for the involvement of amyloid β-peptides
by Taylor, Shafeena C and Batten, Trevor F. C and Peers, Chris
The Journal of biological chemistry, ISSN 0021-9258, 10/1999, Volume 274, Issue 44, pp. 31217 - 31222
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Alzheimer Disease - etiology | Oxygen - pharmacology | Peptide Fragments - metabolism | Catecholamines - metabolism | Calcium - metabolism | Humans | Cadmium - pharmacology | Rats | Potassium - pharmacology | PC12 Cells | Exocytosis - drug effects | Hypoxia-Ischemia, Brain - complications | Cell Hypoxia | Animals | Amyloid beta-Peptides - metabolism | Biological Transport - drug effects | Index Medicus
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11. Full Text N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia
by Condic, Mateja and Oberstein, Timo Jan and Herrmann, Martin and Reimann, Mareike Carola and Kornhuber, Johannes and Maler, Juan Manuel and Spitzer, Philipp
Brain, behavior, and immunity, ISSN 0889-1591, 2014, Volume 41, Issue 1, pp. 116 - 125
Psychiatry | Allergy and Immunology | Monocyte | Macrophage polarization | Opsonization | Aβ-peptides | Neuroinflammation | Phagocytosis | Amyloid precursor protein | Macrophage | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Escherichia coli | Humans | Structure-Activity Relationship |