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1. Full Text Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-β peptide
by Hatami, Asa and Monjazeb, Sanaz and Milton, Saskia and Glabe, Charles G
Journal of Biological Chemistry, ISSN 0021-9258, 02/2017, Volume 292, Issue 8, pp. 3172 - 3185
Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases, called familial AD (FAD), are associated with mutations in presenilin... 
THIOFLAVIN-T | Alzheimer disease | PROTOFIBRIL FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | aggregation | amyloid- (A) | CEREBRAL-HEMORRHAGE | A-BETA | SMOOTH-MUSCLE-CELLS | PRESENILIN MUTATIONS | ANGIOPATHY | monoclonal antibody | peptide conformation | MONOCLONAL-ANTIBODIES | ENGLISH H6R | TOTTORI D7N | Protein Aggregates | Amyloid beta-Protein Precursor - ultrastructure | Amyloid beta-Protein Precursor - genetics | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - ultrastructure | Humans | Amyloid beta-Peptides - analysis | Protein Conformation | Amyloid beta-Protein Precursor - analysis | Mutation | Alzheimer Disease - genetics | Alzheimer Disease - pathology | Index Medicus | Protein Structure and Folding | amyloid-β (Aβ)
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2. Full Text Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression
by Semar, Sandra and Klotz, Markus and Letiembre, Maryse and Van Ginneken, Chris and Braun, Anne and Jost, Viktor and Bischof, Michael and Lammers, Wim J and Liu, Yang and Fassbender, Klaus and Wyss-Coray, Tony and Kirchhoff, Frank and Schafer, Karl-Herbert
Journal of Alzheimer's Disease, ISSN 1387-2877, 2013, Volume 36, Issue 1, pp. 7 - 20
In Alzheimer's disease (AD), fatal neuronal cell loss occurs long before relevant evidence can lead to a reliable diagnosis. If characteristic pathological... 
amyloid-β protein precursor | enteric nervous system | Alzheimer's disease | potential biomarker | ALZHEIMER-DISEASE | APP | DIAGNOSIS | CELLS | GASTROINTESTINAL-TRACT | amyloid-beta protein precursor | COLONIC MOTILITY | NEUROSCIENCES | MOUSE MODELS | DEPOSITS | MYENTERIC PLEXUS | COGNITIVE DEFICITS | Enteric Nervous System - chemistry | Enteric Nervous System - pathology | Gene Expression | Mice, Inbred C57BL | Biomarkers - analysis | Mice, Transgenic | Amyloid beta-Protein Precursor - analysis | Blotting, Western | Disease Progression | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Gastrointestinal Motility | Animals | Alzheimer Disease - metabolism | Proteomics | Mice | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Index Medicus
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3. Full Text Renal Transplantation in Systemic Amyloidosis—Importance of Amyloid Fibril Type and Precursor Protein Abundance
by Pinney, J. H and Lachmann, H. J and Sattianayagam, P. T and Gibbs, S. D. J and Wechalekar, A. D and Venner, C. P and Whelan, C. J and Gilbertson, J. A and Rowczenio, D and Hawkins, P. N and Gillmore, J. D
American Journal of Transplantation, ISSN 1600-6135, 02/2013, Volume 13, Issue 2, pp. 433 - 441
Renal transplantation remains contentious in patients with systemic amyloidosis due to the risk of graft loss from recurrent amyloid and progressive disease.... 
clone | Amyloidosis | precursor protein | survival | serum amyloid A protein | SURGERY | DIAGNOSIS | ALPHA-CHAIN AMYLOIDOSIS | SERUM | AA AMYLOIDOSIS | HEPATORENAL TRANSPLANTATION | TRANSPLANTATION | P COMPONENT SCINTIGRAPHY | KIDNEY-TRANSPLANTATION | HEREDITARY FIBRINOGEN | AL AMYLOIDOSIS | Recurrence | Amyloidosis - therapy | Humans | Middle Aged | Amyloidosis - mortality | Graft Survival | Male | Treatment Outcome | United Kingdom | Amyloid beta-Protein Precursor - analysis | Apolipoprotein A-I - metabolism | Kidney Transplantation - methods | Amyloid - analysis | Kidney Failure, Chronic - therapy | Time Factors | Biopsy | Fibrinogen - metabolism | Adult | Female | Databases, Factual | Transplantation | Kidneys | Chronic kidney failure | Lysozyme | Index Medicus
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4. Full Text Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex
by Pliássova, Anna and Canas, Paula M and Xavier, Ana Carolina and Da Silva, Beatriz S and Cunha, Rodrigo A and Agostinho, Paula
Journal of Alzheimer's Disease, ISSN 1387-2877, 2016, Volume 52, Issue 4, pp. 1209 - 1214
Amyloid-beta protein precursor (A beta PP) is involved in synaptic formation and function. In the human cingulate cortex, A beta PP was preferentially located... 
human brain | amyloid-β protein | sub-synaptic fractions | Aging | β-secretase | synapse | α-secretase | LOCALIZATION | APP | ALZHEIMERS-DISEASE | NEUROSCIENCES | beta-secretase | SYNAPSES | NEUROGENESIS | amyloid-beta protein | alpha-secretase | RECEPTORS | Cerebral Cortex - chemistry | Age Factors | Humans | Middle Aged | Male | Amyloid Precursor Protein Secretases - analysis | Amyloid beta-Protein Precursor - analysis | Young Adult | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Adult | Aged | Synapses - chemistry | Index Medicus
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5. Full Text Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays
by Jason M. Johnson and John Castle and Philip Garrett-Engele and Zhengyan Kan and Patrick M. Loerch and Christopher D. Armour and Ralph Santos and Eric E. Schadt and Roland Stoughton and Daniel D. Shoemaker
Science, ISSN 0036-8075, 12/2003, Volume 302, Issue 5653, pp. 2141 - 2144
Alternative pre-messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are... 
Protein isoforms | Alternative splicing | Messenger RNA | Splicing | Reverse transcriptase polymerase chain reaction | Exons | Genes | Liver | Reports | Genomes | Sequencing | TRANSCRIPTOME | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DIVERSITY | HUMAN GENES | EXPRESSION | ARRAYS | Cell Line | Alternative Splicing | Oligonucleotide Array Sequence Analysis | Humans | Molecular Sequence Data | Protein Isoforms - analysis | RNA Precursors - genetics | Amyloid beta-Protein Precursor - analysis | Proteins - analysis | Reverse Transcriptase Polymerase Chain Reaction | Proteins - genetics | Tissue Distribution | Phosphoric Monoester Hydrolases | Amyloid beta-Protein Precursor - genetics | Hydroxymethylglutaryl CoA Reductases - analysis | ROC Curve | Genome, Human | Hydroxymethylglutaryl CoA Reductases - genetics | DNA, Complementary | Expressed Sequence Tags | DNA microarrays | Research | Gene expression | RNA splicing | Cellular biology | Ribonucleic acid--RNA | Genetics | Index Medicus
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6. Full Text The Lipoprotein Receptor LR11 Regulates Amyloid beta Production and Amyloid Precursor Protein Traffic in Endosomal Compartments
by Offe, Katrin and Dodson, Sara E and Shoemaker, James T and Fritz, Jason J and Gearing, Marla and Levey, Allan I and Lah, James J
Journal of Neuroscience, ISSN 0270-6474, 02/2006, Volume 26, Issue 5, pp. 1596 - 1603
Alzheimer's disease (AD) is a neurodegenerativedisorder characterized by progressive cognitive decline and neuropathological changes, including the deposition... 
LR11 | Amyloid β | Endocytic pathway | VPS10 | Lipoprotein receptors | Alzheimer's disease | Amyloid precursor protein | SorLA | CYTOPLASMIC DOMAIN | sorLA | HUMAN BRAIN | GENETIC ASSOCIATION | SECRETASE CLEAVAGE | SPORADIC ALZHEIMERS-DISEASE | endocytic pathway | NEUROSCIENCES | amyloid beta | lipoprotein receptors | APOLIPOPROTEIN-E RECEPTOR | FAMILY-MEMBER | MULTIVESICULAR BODIES | amyloid precursor protein | SORTING RECEPTOR | Cell Line | Brain - cytology | Neurons - chemistry | LDL-Receptor Related Proteins | Amyloid beta-Peptides - biosynthesis | Humans | Membrane Transport Proteins - analysis | Rats | Amyloid beta-Protein Precursor - analysis | Receptors, LDL - analysis | Endosomes - metabolism | Membrane Transport Proteins - physiology | Alzheimer Disease - pathology | Protein Transport | Animals | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Endosomes - chemistry | Receptors, LDL - physiology | Index Medicus | Alzheimer’s disease | amyloid β
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7. Full Text O-GlcNAcylation of amyloid-β precursor protein at threonine 576 residue regulates trafficking and processing
by Chun, Yoon Sun and Kwon, Oh-Hoon and Chung, Sungkwon
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2017, Volume 490, Issue 2, pp. 486 - 491
The pathological hallmark of Alzheimer's disease (AD) is associated with the accumulation of amyloid-β (Aβ) derived from proteolytic processing of amyloid-β... 
Amyloid-β protein precursor | O-GlcNAcylation | Amyloid | Alzheimer's disease | APP | DOMAIN | ALZHEIMERS-DISEASE | SORLA/LR11 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOSYLATION | IDENTIFICATION | ENDOCYTOSIS | SENILE PLAQUES | BIOPHYSICS | PURIFICATION | Amyloid-beta protein precursor | LINKED N-ACETYLGLUCOSAMINE | Humans | Amyloid beta-Protein Precursor - analysis | Glycosylation | Threonine - metabolism | Acetylglucosamine - metabolism | Protein Transport | Point Mutation | trans-Golgi Network - metabolism | Amyloid beta-Protein Precursor - genetics | Threonine - genetics | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Threonine - analysis | Cell Membrane - metabolism | Protein Processing, Post-Translational | HeLa Cells | Acylation | Index Medicus
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8. Full Text MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease
by Baranger, Kévin and Marchalant, Yannick and Bonnet, Amandine E and Crouzin, Nadine and Carrete, Alex and Paumier, Jean-Michel and Py, Nathalie A and Bernard, Anne and Bauer, Charlotte and Charrat, Eliane and Moschke, Katrin and Seiki, Mothoharu and Vignes, Michel and Lichtenthaler, Stefan F and Checler, Frédéric and Khrestchatisky, Michel and Rivera, Santiago
Cellular and Molecular Life Sciences, ISSN 1420-682X, 01/2016, Volume 73, Issue 1, pp. 217 - 236
Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The... 
MMP-24 | Neuroprotection | Neurodegenerative disease | Synaptotoxicity | Knockout mouse | HIPPOCAMPAL SYNAPTIC PLASTICITY | MEMORY IMPAIRMENTS | TYPE-5 MATRIX-METALLOPROTEINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | C-TERMINAL FRAGMENT | NEURON LOSS | BACE1 | A-BETA | PRECURSOR PROTEIN | GAMMA-SECRETASE | SECRETED OLIGOMERS | Analysis | Amyloid beta-protein | Genetically modified organisms | Resveratrol | Genetic engineering | Amyloidosis | Alzheimer's disease | Proteins | Nervous system | Membranes | Peptides | Alzheimers disease | Index Medicus | Life Sciences | Neurons and Cognition | Neurobiology
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9. Full Text Single-cell detection of secreted Aβ and sAPPα from human IPSC-derived neurons and astrocytes
by Liao, Mei-Chen and Muratore, Christina R and Gierahn, Todd M and Sullivan, Sarah E and Srikanth, Priya and De Jager, Philip L and Love, J. Christopher and Young-Pearse, Tracy L
Journal of Neuroscience, ISSN 0270-6474, 02/2016, Volume 36, Issue 5, pp. 1730 - 1746
Secreted factors play a central role in normal and pathological processes in every tissue in the body. The brain is composed of a highly complex milieu of... 
Single cell | APP | Microengraving | Alzheimer’s disease | iPSC | CYTOPLASMIC DOMAIN | MIGRATION | ANTIBODIES | ALZHEIMERS-DISEASE | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | single cell | A beta | NEURITE OUTGROWTH | INTERACTION DOMAINS | F-SPONDIN | Alzheimer's disease | microengraving | MODULATION | Cricetinae | Cricetulus | Neurons - chemistry | Induced Pluripotent Stem Cells - chemistry | Humans | Amyloid beta-Peptides - secretion | Induced Pluripotent Stem Cells - secretion | Male | Amyloid beta-Protein Precursor - analysis | Amyloid beta-Protein Precursor - secretion | Animals | Single-Cell Analysis - methods | Amyloid beta-Peptides - analysis | Astrocytes - chemistry | Female | Neurons - secretion | Astrocytes - secretion | CHO Cells | Index Medicus
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10. Full Text Pulsatile stretch as a novel modulator of amyloid precursor protein processing and associated inflammatory markers in human cerebral endothelial cells
by Gangoda, Sumudu V. S and Avadhanam, Bhargava and Jufri, Nurul F and Sohn, Eun Hwa and Butlin, Mark and Gupta, Vivek and Chung, Roger and Avolio, Alberto P
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1689 - 10
Amyloid beta (A beta) deposition is a hallmark of Alzheimer's disease (AD). Vascular modifications, including altered brain endothelial cell function and... 
UNIAXIAL CYCLIC STRETCH | ADHESION | OVEREXPRESSION | ACTIVATION | NITRIC-OXIDE PRODUCTION | PEPTIDES | INHIBITION | MULTIDISCIPLINARY SCIENCES | A-BETA | EXPRESSION | BRAIN | Humans | Cells, Cultured | Pulse | Cytological Techniques - methods | Nitric Oxide Synthase Type III - analysis | Stress, Mechanical | Amyloid Precursor Protein Secretases - analysis | Amyloid beta-Protein Precursor - analysis | Aspartic Acid Endopeptidases - analysis | Gene Expression Profiling | Alzheimer Disease - pathology | Models, Biological | Endothelial Cells - pathology | Intercellular Adhesion Molecule-1 - analysis | Phosphorylation | Intercellular adhesion molecule 1 | Neurodegenerative diseases | Secretion | Inflammation | Amyloid precursor protein | Endothelial cells | Nitric-oxide synthase | Blood-brain barrier | Nitric oxide | Cell adhesion | Alzheimer's disease | Secretase | Index Medicus
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11. Full Text Azure B affects amyloid precursor protein metabolism in PS70 cells
by Biberoglu, Kevser and Yuksel, Melike and Tacal, Ozden
Chemico-Biological Interactions, ISSN 0009-2797, 02/2019, Volume 299, pp. 88 - 93
Alzheimer's disease (AD), the most common form of dementia, is characterized by abundant deposition of amyloid-β (Aβ) peptide that is the result of sequential... 
Amyloid β peptide | Azure B | Alzheimer's disease | Amyloid precursor protein | METHYLENE-BLUE | BUTYRYLCHOLINESTERASE | TOLUIDINE BLUE O | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETASE CLEAVAGE | TAU | CHOLINESTERASE-INHIBITORS | PATHOLOGY | MOUSE MODEL | A-BETA | PHARMACOLOGY & PHARMACY | Amyloid beta peptide | TOXICOLOGY | OLIGOMERIZATION | Cell Survival - drug effects | Cricetinae | Peptide Fragments - metabolism | Cricetulus | Humans | Presenilin-1 - genetics | Amyloid beta-Protein Precursor - analysis | Azure Stains - pharmacology | Down-Regulation - drug effects | Peptide Fragments - analysis | Up-Regulation - drug effects | Animals | Presenilin-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Amyloid beta-Peptides - analysis | CHO Cells | Index Medicus
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12. Full Text Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
by M. Azhar Chishti and Dun-Shen Yang and Christopher Janus and Amie L. Phinney and Patrick Horne and Jacqueline Pearson and Robert Strome and Noah Zuker and James Loukides and Janet French and Sherry Turner and Gianluca Lozza and Mariagrazia Grilli and Suzanne Kunicki and Céline Morissette and Julie Paquette and Francine Gervais and Catherine Bergeron and Paul E. Fraser and George A. Carlson and Peter St. George-Hyslop and David Westaway
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 24, pp. 21562 - 21570
We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid β-peptide (Aβ)... 
NEUROFIBRILLARY TANGLES | CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | FAMILIAL ALZHEIMERS-DISEASE | A-BETA PEPTIDE | PLAQUES | NEURONAL LOSS | BRAIN | PRESENILIN-1 | Amyloid beta-Protein Precursor - chemistry | Humans | Male | Amyloid beta-Protein Precursor - analysis | Brain - growth & development | Restriction Mapping | Amyloid - analysis | Amyloidosis - genetics | Amyloid beta-Protein Precursor - metabolism | Aging | Female | Amyloid - genetics | Promoter Regions, Genetic | Mutagenesis, Site-Directed | Amyloidosis - pathology | Amyloidosis - psychology | Maze Learning - physiology | Mice, Inbred C57BL | Cognition Disorders - pathology | Mice, Transgenic | Cognition Disorders - genetics | Mice, Inbred C3H | Amyloid beta-Protein Precursor - genetics | Animals | Brain - pathology | Mice | Amino Acid Substitution | Crosses, Genetic | PrP gene | Index Medicus
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13. Full Text beta-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System
by Almeida, Claudia G and Takahashi, Reisuke H and Gouras, Gunnar K
Journal of Neuroscience, ISSN 0270-6474, 04/2006, Volume 26, Issue 16, pp. 4277 - 4288
Increasing evidence links intraneuronal beta-amyloid (A beta(42)) accumulation with the pathogenesis of Alzheimer's disease (AD). In A beta precursor protein... 
Endocytosis | TrkB | Neuron | Alzheimer's disease | Endosome | EGFR | ENDOCYTIC PATHWAY | ALZHEIMERS-DISEASE | neuron | AXONAL-TRANSPORT | INTRANEURONAL A-BETA-42 ACCUMULATION | NEUROSCIENCES | DEUBIQUITINATING ENZYMES | endosome | DOWN-SYNDROME | endocytosis | NEURONAL CELLS | PRECURSOR PROTEIN | EGF RECEPTOR | TRANSGENIC MICE | Ubiquitin - analysis | Synaptic Vesicles - metabolism | Hippocampus - chemistry | Humans | Ubiquitin - metabolism | Male | Amyloid beta-Protein Precursor - analysis | Proteasome Endopeptidase Complex - analysis | Receptor, Epidermal Growth Factor - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Synaptic Vesicles - chemistry | Hippocampus - enzymology | Ubiquitin - antagonists & inhibitors | Cells, Cultured | Rats | Epidermal Growth Factor - metabolism | Mice, Transgenic | Receptor, Epidermal Growth Factor - analysis | Rats, Sprague-Dawley | Hippocampus - metabolism | Animals | Amyloid beta-Peptides - analysis | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Synaptic Vesicles - enzymology | Index Medicus
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14. Full Text Homo- and heterodimerization of APP family members promotes intercellular adhesion
by Wagner, Katja and Merdes, Gunter and Paro, Renato and Masters, Colin L and Löwer, Alexander and Soba, Peter and Kreger, Sylvia and Müller, Ulrike and Siehl, Katjuscha and Langer, Andreas and Kins, Stefan and Beyreuther, Konrad and Eggert, Simone and Zentgraf, Hanswalter
The EMBO Journal, ISSN 0261-4189, 10/2005, Volume 24, Issue 20, pp. 3624 - 3634
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease, but its physiological function and that of its mammalian paralogs, the amyloid... 
dimerization | APP | Alzheimer's disease | cell adhesion | Dimerization | Cell adhesion | CELLS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | IDENTIFICATION | MICE LACKING | DROSOPHILA | CELL BIOLOGY | GENE FAMILY | EXPRESSION | EGF RECEPTOR | BRAIN | Protein Structure, Tertiary | Fibroblasts - physiology | Humans | Nerve Tissue Proteins - analysis | Synaptic Membranes - chemistry | Receptors, Cell Surface - metabolism | Amyloid beta-Protein Precursor - analysis | Cell Adhesion | Nerve Tissue Proteins - genetics | Protein Interaction Mapping | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid beta-Protein Precursor - metabolism | Protease Nexins | Mice | Synaptic Membranes - metabolism | Fibroblasts - metabolism | Index Medicus
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