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Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 96 - 99
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2006, Volume 281, Issue 21, pp. 14776 - 14786
We showed previously that cells expressing wild-type (WT) beta-amyloid precursor protein (APP) or coexpressing WTAPP and WT presenilin (PS) 1/2 produced APP... 
Protein Structure, Tertiary | Cricetinae | Amyloid beta-Protein Precursor - chemistry | Endopeptidases - chemistry | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Amyloid Precursor Protein Secretases | Protein Binding | Amyloid beta-Peptides - chemistry | Kinetics | Mutation | CHO Cells | Index Medicus
Journal Article
Biophysical Journal, ISSN 0006-3495, 03/2015, Volume 108, Issue 5, pp. 1229 - 1237
Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases... 
LIPIDOMICS | CELLS | COMPLEX | BIOPHYSICS | PATHWAY | MEMBRANE | MODULATORS | PRESENILIN/GAMMA-SECRETASE | FAMILIAL ALZHEIMERS-DISEASE | MUTATIONS | INHIBITOR | Amyloid Precursor Protein Secretases - metabolism | Proteolysis | Amyloid beta-Protein Precursor - chemistry | Humans | HEK293 Cells | Kinetics | Intracellular Membranes - chemistry | Index Medicus | Proteins and Nucleic Acids
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 11, pp. 9646 - 9656
Abnormally high concentrations of Zn(2+), Cu(2+), and Fe(3+) are present along with amyloid-β (Aβ) in the senile plaques in Alzheimer disease, where Al(3+) is... 
Copper - chemistry | Aluminum - chemistry | Amyloid beta-Protein Precursor - chemistry | Humans | Iron - chemistry | Protein Multimerization | Amyloid - chemistry | Protein Stability | Amyloid - ultrastructure | Zinc - chemistry | Index Medicus | Protein Structure and Folding | Amyloid | Kinetics | Alzheimer Disease | Metals | Protein Folding
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2016, Volume 138, Issue 13, pp. 4634 - 4642
High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to understand the molecular basis of Alzheimer's disease and develop... 
Peptide Fragments - chemistry | Amyloid beta-Protein Precursor - chemistry | Humans | Crystallography, X-Ray | Amyloid beta-Peptides - chemistry | Alzheimer Disease | Macromolecular Substances | Index Medicus
Journal Article