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Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 482, Issue 7384, pp. 216 - 220
...). Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-beta precursor protein gene(1) (APP; termed APP(Dp... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2015, Volume 589, Issue 18, pp. 2394 - 2400
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 18, Issue 3, pp. 425 - 436
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2017, Volume 55, Issue 4, pp. 1549 - 1570
...). We studied herein the subcellular distribution, the processing, and the protein interactome of the amyloid-beta protein precursor (A beta PP... 
proteomic | lipids | amyloid-β protein precursor | mitochondria associated membranes | Alzheimer disease | ALZHEIMERS-DISEASE BRAIN | amyloid-beta protein precursor | NEUROSCIENCES | C-TERMINAL FRAGMENT | PROTEOLYTIC ACTIVITY | ER MEMBRANES | CELLULAR PRION | LIPID RAFTS | MOUSE MODEL | A-BETA | ENDOPLASMIC-RETICULUM | GAMMA-SECRETASE | Immunoprecipitation | Cricetulus | Humans | Ryanodine Receptor Calcium Release Channel - metabolism | Mitochondria - ultrastructure | Quinolines - pharmacology | Electron Transport Complex IV - metabolism | Transfection | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Cell Membrane - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Cell Membrane - drug effects | Neuroblastoma - pathology | CHO Cells | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | Voltage-Dependent Anion Channel 1 - metabolism | Gene Expression Regulation - physiology | Presenilin-1 - genetics | Mice, Transgenic | Cell Membrane - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Microscopy, Electron | Mutation - genetics | Gene Expression Regulation - drug effects | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Presenilin-1 - metabolism | Cell Line, Tumor | Mice | Membranes | Deregulation | Animal models | Neurodegenerative diseases | Pathogenesis | Transgenic mice | Proteins | Mitochondria | Proteolysis | Rodents | Amyloid | Mutation | Localization | Alzheimer's disease | Catabolites | Life Sciences
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2016, Volume 36, Issue 35, pp. 9041 - 9056
Journal Article
Nature, ISSN 0028-0836, 06/2008, Volume 453, Issue 7197, pp. 925 - 929
Journal Article
Journal Article