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1. Full Text Oxidative stress and the amyloid beta peptide in Alzheimer's disease
by Cheignon, C and Tomas, M and Bonnefont-Rousselot, D and Faller, P and Hureau, C and Collin, F
Redox Biology, ISSN 2213-2317, 04/2018, Volume 14, pp. 450 - 464
Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer's... 
Oxidative stress | Reactive oxygen species | Amyloid beta peptide | Metal-ions | Oxidative damages | CU(II) BINDING-SITES | LIPID-PEROXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MILD COGNITIVE IMPAIRMENT | METAL-CATALYZED OXIDATION | NEURODEGENERATIVE DISEASES | A-BETA | AMINO-ACID-RESIDUES | PRECURSOR PROTEIN | REDOX PROTEOMICS IDENTIFICATION | RECEPTOR-RELATED PROTEIN-1
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2. Full Text Alzheimer's Disease and the Amyloid-beta Peptide
by Murphy, MP and LeVine, H
JOURNAL OF ALZHEIMERS DISEASE, ISSN 1387-2877, 2010, Volume 19, Issue 1, pp. 311 - 323
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-beta peptide (A beta). For many years,... 
INSULIN-DEGRADING ENZYME | oligomer | amyloid-beta protein precursor | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | PITTSBURGH COMPOUND-B | PLAQUE CORE PROTEIN | SENILE PLAQUES | APP TRANSGENIC MICE | fibril | POSITRON-EMISSION-TOMOGRAPHY | A-BETA | GAMMA-SECRETASE ACTIVITY | PRECURSOR PROTEIN | Amyloid-beta
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3. Full Text Oxidation destabilizes toxic amyloid beta peptide aggregation
by Razzokov, J and Yusupov, M and Bogaerts, A
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5476 - 7
The aggregation of insoluble amyloid beta (A beta) peptides in the brain is known to trigger the onset of neurodegenerative diseases, such as Alzheimer's... 
FIBRIL STRUCTURE | PROTEIN | ATOMIC-RESOLUTION STRUCTURE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | SIMULATIONS | β-Amyloid | Oxidation | Peptides | Neurodegenerative diseases | Free energy
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4. Full Text Amyloid Beta Peptide Folding in Reverse Micelles
by Eskici, Gözde and Axelsen, Paul H
Journal of the American Chemical Society, ISSN 0002-7863, 07/2017, Volume 139, Issue 28, pp. 9566 - 9575
Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a... 
FIBRIL FORMATION | PROTEIN | AMIDE-I | ALZHEIMERS-DISEASE | SHEET STRUCTURE | AB-INITIO | MEMBRANES | INFRARED-SPECTROSCOPY | MOLECULAR-DYNAMICS SIMULATIONS | CHEMISTRY, MULTIDISCIPLINARY | AGGREGATION | Software | Amyloid beta-Peptides - chemistry | Micelles | Molecular Dynamics Simulation | Protein Folding | Chemical properties | Research | Structure | Protein folding | Amyloid beta-protein
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5. Full Text Alzheimer's disease and the amyloid-β peptide
by Murphy, M. Paul and Levine III, Harry
Journal of Alzheimer's Disease, ISSN 1387-2877, 2010, Volume 19, Issue 1, pp. 311 - 323
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-beta peptide (Abeta). For many years,... 
Amyloid-β protein precursor | Amyloid-β | Oligomer | Fibril | Peptide Fragments - metabolism | Amyloid beta-Peptides - biosynthesis | Humans | Peptide Fragments - biosynthesis | Alzheimer Disease - pathology | Polymorphism, Genetic | Brain - metabolism | Animals | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Protein Conformation | Alzheimer Disease - genetics | Peptide Fragments - genetics
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6. Full Text Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
by Castellano, Joseph M and Kim, Jungsu and Stewart, Floy R and Jiang, Hong and DeMattos, Ronald B and Patterson, Bruce W and Fagan, Anne M and Morris, John C and Mawuenyega, Kwasi G and Cruchaga, Carlos and Goate, Alison M and Bales, Kelly R and Paul, Steven M and Bateman, Randall J and Holtzman, David M
Science Translational Medicine, ISSN 1946-6234, 06/2011, Volume 3, Issue 89, pp. 89ra57 - 89ra57
The apolipoprotein E (APOE) epsilon 4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE epsilon 4 allele... 
FIBRIL FORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | MOUSE MODEL | IN-VIVO | A-BETA | ONSET ALZHEIMER-DISEASE | CENTRAL-NERVOUS-SYSTEM | CEREBROSPINAL-FLUID A-BETA | PITTSBURGH COMPOUND-B | DENSITY-LIPOPROTEIN RECEPTOR | APOLIPOPROTEIN-E | CELL BIOLOGY | Apolipoprotein E4 - genetics | Apolipoprotein E4 - metabolism | Humans | Mice, Inbred C57BL | Middle Aged | Genotype | Male | Mice, Transgenic | Alzheimer Disease - pathology | Brain - metabolism | Animals | Microdialysis | Protein Isoforms - metabolism | Alleles | Alzheimer Disease - metabolism | Amyloid beta-Peptides - cerebrospinal fluid | Brain - pathology | Adult | Female | Aged | Mice | Biomarkers - cerebrospinal fluid | Alzheimer Disease - genetics | Protein Isoforms - genetics
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7. Full Text Amyloid Seeds Formed by Cellular Uptake, Concentration, and Aggregation of the Amyloid-Beta Peptide
by Xiaoyan Hu and Scott L. Crick and Guojun Bu and Carl Frieden and Rohit V. Pappu and Jin-Moo Lee
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 48, pp. 20324 - 20329
One of the neuropathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque, primarily composed of aggregated amyloid-beta (Aβ) peptide. In vitro,... 
Aggregation | Brain | Mental concentration | HEK293 cells | Neurons | Cell aggregates | Fluorescence | Amyloids | Alzheimers disease | Cell extracts | Lysosomes | Amyloid fibrils | Late endosomes | Plaques | FIBRIL FORMATION | HUMAN BRAIN | PROTEIN AGGREGATION | plaques | ALZHEIMERS-DISEASE | DEPOSITION | MULTIDISCIPLINARY SCIENCES | INTERSTITIAL FLUID | INTRANEURONAL A-BETA-42 ACCUMULATION | APOLIPOPROTEIN-E | late endosomes | amyloid fibrils | IN-VITRO MODEL | A-BETA | lysosomes | Alzheimer Disease - physiopathology | Humans | Immunoblotting | Microscopy, Confocal | Animals | Amyloid beta-Peptides - metabolism | Cytoplasmic Vesicles - metabolism | Thiazoles | Cell Line, Tumor | Plaque, Amyloid - metabolism | Mice | Neurons - metabolism | Amyloid beta-Peptides - pharmacokinetics | Properties | Amyloid beta-protein | Biological Sciences
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8. Full Text The amyloid beta peptide: A chemist's perspective. role in Alzheimer's and fibrillization
by Hamley, I.W
Chemical Reviews, ISSN 0009-2665, 10/2012, Volume 112, Issue 10, pp. 5147 - 5192
GAMMA-SECRETASE INHIBITOR | SELF-ASSEMBLED MONOLAYERS | ATOMIC-FORCE MICROSCOPY | SOLID-STATE NMR | PROTEIN TRANSGENIC MICE | X-RAY-DIFFRACTION | LONG-TERM POTENTIATION | NICOTINIC ACETYLCHOLINE-RECEPTORS | MILD COGNITIVE IMPAIRMENT | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | Amino Acid Sequence | Humans | Alzheimer Disease - drug therapy | Models, Molecular | Molecular Sequence Data | Animals | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - ultrastructure | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Protein Conformation | Amyloid beta-Peptides - chemistry | Mutation | Alzheimer Disease - genetics | Care and treatment | Usage | Magnetic resonance imaging | Peptides | Mitochondrial DNA | Genetic aspects | Diagnosis | Chemical properties | Structure | Alzheimer's disease
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9. Full Text Natural human antibodies to amyloid beta peptide
by Szabo, Paul and Relkin, Norman and Weksler, Marc E
Autoimmunity Reviews, ISSN 1568-9972, 2008, Volume 7, Issue 6, pp. 415 - 420
Abstract Properties of human, natural anti-Aβ antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the... 
Allergy and Immunology | Avidity | Neurotoxicity | Aβ peptide | Antibody “masking” | Natural anti-Aβ antibodies | Antibody "masking" | PROTEIN | ALZHEIMERS-DISEASE | PATHOLOGY | IMMUNOLOGY | MEMORY LOSS | avidity | PATHOGENESIS | antibody "masking" | IMMUNIZATION | neurotoxicity | MOUSE MODEL | A-BETA | natural anti-A beta antibodies | A beta peptide | Antibody Specificity | Immunoglobulin G - blood | Autoantibodies - blood | Humans | Peptides - immunology | Alzheimer Disease - drug therapy | Amyloid beta-Peptides - antagonists & inhibitors | Autoantibodies - immunology | Immunoglobulin M - blood | Immunoglobulins, Intravenous - therapeutic use | Autoantibodies - therapeutic use | Amyloid beta-Peptides - immunology | Epitopes - chemistry | Immunoglobulins, Intravenous - immunology | Peptides | Immunoglobulins | Index Medicus
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10. Full Text Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
by Kumar, Deepak Kumar Vijaya and Choi, Hoon Se and Washicosky, Kevin J and Eimer, William A and Tucker, Stephanie and Ghofrani, Jessica and Lefkowitz, Aaron and McColl, Gawain and Goldstein, Lee E and Tanzi, Rudolph E and Moir, Robert D
Science Translational Medicine, ISSN 1946-6234, 05/2016, Volume 8, Issue 340, p. 340ra72
The amyloid-beta peptide (A beta) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting that A beta is an... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CAENORHABDITIS-ELEGANS | A-BETA(1-42) | ANTIMICROBIAL PEPTIDE | PRECURSOR PROTEIN | MUTATIONS | EXPRESSION | BINDING | BRAIN | BALB/C MICE | CELL BIOLOGY | Alzheimer Disease - microbiology | Amyloid beta-Peptides - physiology | Caenorhabditis elegans - microbiology | Caenorhabditis elegans - metabolism | Salmonella typhimurium - pathogenicity | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Humans | Immunity, Innate - genetics | Mice, Transgenic | Animals | Amyloid beta-Peptides - genetics | Immunity, Innate - physiology | Alzheimer Disease - metabolism | Female | Mice | Alzheimer Disease - genetics | Disease Models, Animal
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11. Full Text Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity
by Oliveri, V and Zimbone, S and Giuffrida, ML and Bellia, F and Tomasello, MF and Vecchio, G
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 04/2018, Volume 24, Issue 24, pp. 6349 - 6353
Although fibrillar amyloid beta peptide (A) aggregates are one of the major hallmarks of Alzheimer's disease, increasing evidence suggests that soluble A... 
CELLS | therapeutics | ALZHEIMERS-DISEASE | neurodegeneration | ALPHA-SYNUCLEIN | ANTIOXIDANT MODULATORS | CHEMISTRY, MULTIDISCIPLINARY | OLIGOMERS | aggregate | amyloid | LIGANDS | INHIBITORS | zinc | DERIVATIVES
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12. Full Text Mitochondrial import and degradation of amyloid-β peptide
by Pinho, Catarina Moreira and Teixeira, Pedro Filipe and Glaser, Elzbieta and Institutionen för biokemi och biofysik and Stockholms universitet and Naturvetenskapliga fakulteten
BBA - Bioenergetics, ISSN 0005-2728, 07/2014, Volume 1837, Issue 7, pp. 1069 - 1074
Mitochondrial dysfunctions associated with amyloid-β peptide (Aβ) accumulation in mitochondria have been observed in Alzheimer's disease (AD) patients' brains... 
Degradation | MAM | Presequence protease | Mitochondria | Amyloid-β peptide | PreP | INSULIN-DEGRADING ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALZHEIMERS-DISEASE NEURONS | BIOPHYSICS | MEMORY | Amyloid-beta peptide | MOUSE MODEL | A-BETA | ENDOPLASMIC-RETICULUM | PRECURSOR PROTEIN | DYSFUNCTION | ABNORMAL INTERACTION | TRANSGENIC MICE | Index Medicus | Biological Sciences | Biofysik | Biophysics | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences
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13. Full Text Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity
by Oliveri, Valentina and Zimbone, Stefania and Giuffrida, Maria Laura and Bellia, Francesco and Tomasello, Marianna Flora and Vecchio, Graziella
Chemistry – A European Journal, ISSN 0947-6539, 04/2018, Volume 24, Issue 24, pp. 6349 - 6353
Although fibrillar amyloid beta peptide (Aβ) aggregates are one of the major hallmarks of Alzheimer's disease, increasing evidence suggests that soluble Aβ... 
neurodegeneration | therapeutics | amyloid | zinc | aggregate | Oligomers | Peptides | Therapeutics | Cyclodextrins | Plants | Alzheimer's disease | Homeopathy | Materia medica and therapeutics | Porphyrins | Biological properties | Neurodegenerative diseases | Toxicity | Cytotoxicity | Agglomeration | Zinc | Zinc compounds | Cyclodextrin | β-Amyloid | Alzheimers disease | System effectiveness | Index Medicus
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14. Full Text PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage
by Martire, Sara and Fuso, Andrea and Rotili, Dante and Tempera, Italo and Giordano, Cesare and De Zottis, Ivana and Muzi, Alessia and Vernole, Patrizia and Graziani, Grazia and Lococo, Emanuela and Faraldi, Martina and Maras, Bruno and Scarpa, Sigfrido and Mosca, Luciana and d'Erme, Maria
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e72169
Amyloid beta peptide (A beta) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the... 
ISCHEMIA-REPERFUSION INJURY | ADP-RIBOSE POLYMERASE-1 | SIGNAL-TRANSDUCTION | OXIDATIVE STRESS | DNA-BINDING | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | A-BETA | POLY(ADP-RIBOSE) POLYMERASE-1 | NF-KAPPA-B | NEUROBLASTOMA-CELLS | Cell Line | Cricetinae | Reactive Oxygen Species - metabolism | Cricetulus | Amyloid beta-Peptides - toxicity | Peptide Fragments - toxicity | Mice, Transgenic | DNA Primers | Poly(ADP-ribose) Polymerases - physiology | Comet Assay | Animals | Base Sequence | Electrophoretic Mobility Shift Assay | Mice | DNA Damage | Poly (ADP-Ribose) Polymerase-1 | Neurons - drug effects | CHO Cells | Genetic engineering | Peptides | Tumor proteins | Neurons | Sugars | Monosaccharides | Oxidative stress | Reactive oxygen species | Neurosciences | Bcl-2 protein | p53 Protein | DNA damage | Neuroblastoma | Kinases | ADP | Neuroblastoma cells | Proteins | Signal transduction | Neurotoxicity | Neurodegeneration | Ribose | Rodents | Pretreatment | Damage | Deoxyribonucleic acid--DNA | NF-κB protein | Medical research | Enzymes | Free radicals | Transgenic mice | Poly(ADP-ribose) polymerase | Gene expression | Polymerase | Poly(ADP-ribose) Polymerase 1 | Brain research | β-Amyloid | Alzheimers disease | Cancer | Apoptosis | Deoxyribonucleic acid | DNA
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15. Full Text Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide
by Faller, Peter and Hureau, Christelle and Berthoumieu, Olivia
Inorganic Chemistry, ISSN 0020-1669, 11/2013, Volume 52, Issue 21, pp. 12193 - 12206
Aggregation of amyloid-beta (A beta) by self-assembly into oligomers or amyloids is a central event in Alzheimer's disease. Coordination of transition-metal... 
IN-VITRO | STRUCTURAL BASIS | INDUCED AGGREGATION | A-BETA | REDOX CHEMISTRY | PRECURSOR PROTEIN | COPPER COORDINATION | ZINC-BINDING | NEURODEGENERATIVE DISEASES | PHYSIOLOGICAL CONCENTRATIONS | CHEMISTRY, INORGANIC & NUCLEAR | Amyloid - metabolism | Zinc - metabolism | Humans | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Copper - metabolism | Amyloid - chemistry | Amyloid beta-Peptides - chemistry | Alzheimer Disease - pathology | Hydrogen-Ion Concentration
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16. Full Text AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-β peptide metabolism
by Vingtdeux, Valérie and Giliberto, Luca and Zhao, Haitian and Chandakkar, Pallavi and Wu, Qingli and Simon, James E and Janle, Elsa M and Lobo, Jessica and Ferruzzi, Mario G and Davies, Peter and Marambaud, Philippe
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 12, pp. 9100 - 9113
Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-beta (A beta) peptide deposition into cerebral amyloid plaques. The... 
CANCER-CELLS | LIFE-SPAN | IN-VITRO | GALLIC ACID | ALZHEIMERS-DISEASE | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | DIETARY RESTRICTION | SIRT1 ACTIVATION | GAMMA-SECRETASE | AMP-Activated Protein Kinases - metabolism | Signal Transduction | Calcium - metabolism | Humans | Enzyme Inhibitors - pharmacology | Male | Mice, Transgenic | Stilbenes - pharmacology | Autophagy | Animals | Lysosomes - metabolism | Alzheimer Disease - metabolism | Cytosol - metabolism | Mice | Neurons - metabolism | Amyloid beta-Peptides - chemistry | Secretases | Calcium | Protein Kinases | Proteases | Neurobiology | Resveratrol | Amyloid | Alzheimer Disease | Diseases
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