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Brain Research, ISSN 0006-8993, 05/2006, Volume 1089, Issue 1, pp. 67 - 78
Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Aβ deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains,... 
Cerebrovascular amyloid | Amyloid-β protein | Small heat shock protein | Alzheimer's disease | Fibrillization | HSPB8 | ALPHA-B-CRYSTALLIN | ALZHEIMERS-DISEASE BRAINS | CHAPERONE | NEUROSCIENCES | VESSEL WALL | HUMAN BRAIN PERICYTES | fibrillization | IN-VITRO | small heat shock protein | A-BETA | amyloid-beta protein | SMOOTH-MUSCLE-CELLS | cerebrovascular amyloid | EXPRESSION | Protein Binding - genetics | Humans | Neoplasm Proteins - pharmacology | Cerebral Amyloid Angiopathy - metabolism | Neoplasm Proteins - metabolism | alpha-Crystallins - metabolism | HSP20 Heat-Shock Proteins - metabolism | Neuroprotective Agents - metabolism | HSP20 Heat-Shock Proteins - pharmacology | Neuroprotective Agents - pharmacology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Peptide Fragments - genetics | Alzheimer Disease - physiopathology | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Cerebral Amyloid Angiopathy - physiopathology | Heat-Shock Proteins - metabolism | Cells, Cultured | Cerebral Arteries - physiopathology | Heat-Shock Proteins - pharmacology | Mutation - genetics | Amyloid beta-Peptides - antagonists & inhibitors | alpha-Crystallins - pharmacology | Cerebral Arteries - metabolism | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Amyloid beta-Peptides - chemistry | HSP27 Heat-Shock Proteins
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 468, Issue 1, pp. 145 - 158
The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and... 
Presenilin-1 | Arc | Oligomerization | Protein purification | Synaptic plasticity | Protein stability | Biophysical characterization | IMMEDIATE-EARLY GENE | CYTOSKELETON-ASSOCIATED PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein purification | INTRINSICALLY UNSTRUCTURED PROTEINS | ARC/ARG3.1 | biophysical characterization | protein stability | CONSOLIDATION | oligomerization | DENDRITIC SPINE | DIFFERENTIAL SCANNING FLUOROMETRY | SEQUENCE ALIGNMENTS | synaptic plasticity | LONG-TERM POTENTIATION | presenilin-1 | Cytoskeletal Proteins - genetics | Humans | Protein Multimerization | Molecular Sequence Data | Genetic Variation | Nerve Tissue Proteins - chemistry | Neuronal Plasticity - physiology | Protein Structure, Quaternary | Cytoskeletal Proteins - physiology | Protein Stability | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Nerve Tissue Proteins - physiology | Biophysical Phenomena | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cytoskeletal Proteins - chemistry | Microscopy, Electron | Nerve Tissue Proteins - genetics | Sequence Homology, Amino Acid | Presenilin-1 - metabolism | Protein Binding | Amino Acid Substitution | WT, wild-type | Dh, hydrodynamic diameter | HCA, hydrophobic cluster analysis | TBST, Tris-buffered saline | F-actin, filamentous actin | Aβ, amyloid β-peptide | hArc, human Arc | RT, room temperature | DSC, differential scanning calorimetry | DSF, differential scanning fluorimetry | AMPA, α-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid | LTD, long-term depression | RU, response units | LTP, long-term potentiation | TEV, tobacco etch virus | DLS, dynamic light scattering | 0.1% Tween 20 | Ni-NTA, Ni2+-nitrilotriacetate | Trx, thioredoxin | Arc, activity-regulated cytoskeleton-associated protein | MBP, maltose-binding protein | PS1, presenilin-1 | SPR, surface plasmon resonance | APP, amyloid precursor protein
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3120 - 3138
The cause of protein accumulation in neurodegenerative disease is incompletely understood. In Alzheimer's disease (AD), the axonally enriched protein Tau forms... 
amyloid‐β | protein synthesis | microtubule‐associated protein Tau | Src kinase Fyn | proximity ligation assay | amyloid-β | microtubule-associated protein Tau | S6 PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | SYNAPTIC PLASTICITY | MOUSE MODELS | CELL BIOLOGY | amyloid-beta | COGNITIVE IMPAIRMENTS | PRION PROTEIN | MESSENGER-RNA | T-CELLS | AMYLOID-BETA OLIGOMERS | TRANSGENIC MICE | Neurons - pathology | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | Embryo, Mammalian | Humans | Injections, Intraventricular | tau Proteins - metabolism | Male | Alzheimer Disease - pathology | MAP Kinase Signaling System | Proto-Oncogene Proteins c-fyn - genetics | Neurons - ultrastructure | tau Proteins - genetics | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Puromycin - pharmacology | Neurons - metabolism | Amyloid beta-Peptides - administration & dosage | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Gene Expression Regulation | Hippocampus - pathology | Mice, Knockout | Stereotaxic Techniques | Hippocampus - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Ribosomal Protein S6 Kinases - genetics | Phosphorylation | Translation | Neurodegenerative diseases | Extracellular signal-regulated kinase | Protein biosynthesis | Activation | Pharmacology | Agglomeration | Kinases | Accumulation | Proteins | Signal transduction | Signaling | Detachment | Clonal deletion | Tau protein | Protein synthesis | Microtubules | Deletion | β-Amyloid | Transduction | Alzheimers disease | Alzheimer's disease | Fyn protein | Neuroscience | Protein Biosynthesis & Quality Control
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2015, Volume 470, Issue 3, pp. 303 - 317
Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate that the... 
Amyloid-βpeptide | Protein degradation | Alzheimer's disease | Amyloid precursor protein (APP) | FE65 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | Alzheimer Disease - etiology | Amyloid Precursor Protein Secretases - genetics | Phosphorylation | Cricetulus | Amyloid beta-Protein Precursor - chemistry | Humans | Cercopithecus aethiops | Aspartic Acid Endopeptidases - genetics | Immediate-Early Proteins - metabolism | Nerve Tissue Proteins - chemistry | Proteolysis | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Protein Interaction Domains and Motifs | Protein Stability | Nuclear Proteins - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Recombinant Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Nuclear Proteins - chemistry | Serine - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Immediate-Early Proteins - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Protein Binding | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | COS Cells | serum- and glucocorticoid-induced kinase 1 (SGK1) | amyloid precursor protein (APP) | protein degradation | amyloid-β peptide
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 07/2009, Volume 66, Issue 14, pp. 2299 - 2318
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 12, pp. 2635 - 2645
Ubiquitinated protein aggregates are hallmarks of a range of human diseases, including neurodegenerative, liver and muscle disorders. These protein aggregates... 
Aggregate-prone protein | Huntingtin | Neurodegeneration | Autophagy | p62 | Proteinopathies | aggresome-like inducible structure | APP | Parkinson's disease | Alzheimer disease | ALS | frontotemporal dementia | MDB | ALIS | amyotrophic lateral sclerosis | CREB-binding protein | PI3P | PI3K | ULK | CMA | autophagy-related | blue cheese | mTOR | UPS | unc-51-like kinase | LC3 | MTOC | phosphatidylinositol 3-kinase | TAR DNA binding protein-43 | chaperone-mediated autophagy | ESCRT | DOR | amyloid-β | mammalian Target of Rapamycin | coat protein complex I | LC3-interacting region | Bchs | intermediate filament | TDP-43 | FTD | ROS | MVB | Cvt | Alfy | phospatidylinositol-3-phosphate | microtubule-organizing centre | autophagy-linked FYVE protein | SCA1 | nuclear localization signal | diabetes- and obesity-regulated gene | HDAC6 | CBP | NLS | amyloid precursor protein | UBA | ubiquitin-associated domain | multivesicular body | reactive oxygen species | cytoplasm to vacuole targeting | spinocerebellar ataxia 1 | endosomal sorting complex required for transport | MAP1 light chain 3 | Histone deacetylase 6 | nuclear export signal | Huntington's disease | PML | neighbour of BRCA1 gene 1 | ubiquitin-proteasome system | phosphatidylethanolamine | LIR | Atg | NBR1 | promyelocytic leukemia | COPI | Mallory-Denk body | NES | P62 | POLYGLUTAMINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | FRONTOTEMPORAL DEMENTIA | ALPHA-SYNUCLEIN | INCLUSION-BODY FORMATION | CELL BIOLOGY | BIOPHYSICS | MULTIVESICULAR BODIES | DEGRADATION | HUNTINGTONS-DISEASE | MEDIATED CLEARANCE | MALLORY-DENK-BODIES | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Transcription Factors - chemistry | Neurodegenerative Diseases - etiology | Sequestosome-1 Protein | Humans | Autophagy - physiology | Multiprotein Complexes - metabolism | Ubiquitination | Membrane Proteins - metabolism | Acetylation | Active Transport, Cell Nucleus | Ubiquitinated Proteins - metabolism | Ubiquitinated Proteins - chemistry | Histone Deacetylase 6 | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Neurodegenerative Diseases - therapy | Neurodegenerative Diseases - metabolism | Unfolded Protein Response | Protein Transport | Transcription Factors - metabolism | Multiprotein Complexes - chemistry | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Proteasome Endopeptidase Complex - metabolism | Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism
Journal Article