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Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7295, pp. 223 - 226
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary... 
OPEN-ANGLE GLAUCOMA | COMPLEX | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | EXPRESSION | NEMO | MYOSIN-VI | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Middle Aged | Transcription Factor TFIIIA - genetics | Cytoplasm - metabolism | Male | NF-kappa B - metabolism | Cytoplasm - pathology | Transcription Factor TFIIIA - metabolism | Mutation, Missense - genetics | DNA-Binding Proteins - metabolism | Young Adult | Base Sequence | Aged, 80 and over | Adult | Female | Child | Superoxide Dismutase - metabolism | NF-kappa B - agonists | Amino Acid Sequence | NF-kappa B - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - genetics | Japan | Mutant Proteins - genetics | Transcription Factor TFIIIA - chemistry | Exons - genetics | Mutant Proteins - metabolism | Mutation - genetics | Transcription Factor TFIIIA - analysis | Protein Transport | Amyotrophic Lateral Sclerosis - pathology | Asian Continental Ancestry Group | Pedigree | Mutant Proteins - chemistry | Adolescent | Amyotrophic Lateral Sclerosis - metabolism | Polymorphism, Single Nucleotide - genetics | Aged | Consanguinity | Superoxide Dismutase-1 | Mutant Proteins - analysis | Codon, Nonsense - genetics | Sequence Deletion - genetics | Cellular proteins | Gene mutations | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Research | Health aspects | Risk factors | Haplotypes | Studies | Genes | Genetics | Amino acids | Mutation | Family medical history | Chromosomes | Apoptosis | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 443 - 448
Journal Article
Science, ISSN 0036-8075, 2/2009, Volume 323, Issue 5918, pp. 1205 - 1208
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2017, Volume 58, Issue 1, pp. 267 - 278
As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of... 
Cytochrome p450 | Brain lipids | Cholestenoic acids | Nuclear receptors/lxr | Oxysterols | Mass spectrometry | Neurodeneneration | Bile acids and salts/biosynthesis | cholestenoic acids | brain lipids | HOMEOSTASIS | bile acids and salts/biosynthesis | LIVER-X RECEPTORS | oxysterols | nuclear receptors/LXR | BIOCHEMISTRY & MOLECULAR BIOLOGY | cytochrome P450 | CEREBROSPINAL-FLUID | BLOOD-BRAIN-BARRIER | MASS-SPECTROMETRY | neurodeneneration | PLASMA | CELL-MIGRATION | NEURONS | 27-HYDROXYCHOLESTEROL | mass spectrometry | Neurons - pathology | Bile Acids and Salts - blood | Central Nervous System - metabolism | Cholesterol - blood | Cholesterol - isolation & purification | Humans | Middle Aged | Central Nervous System - pathology | Male | Amyotrophic Lateral Sclerosis - blood | Bile Acids and Salts - cerebrospinal fluid | Nerve Degeneration - pathology | Nerve Degeneration - cerebrospinal fluid | Lipids - isolation & purification | Amyotrophic Lateral Sclerosis - pathology | Lipids - cerebrospinal fluid | Nerve Degeneration - blood | Amyotrophic Lateral Sclerosis - cerebrospinal fluid | Bile Acids and Salts - isolation & purification | Lipids - blood | Female | Aged | Neurons - metabolism | Cholesterol - cerebrospinal fluid | Neuroprotection | Acids | Metabolites | Sterols | Neurodegeneration | Central nervous system | Amyotrophic lateral sclerosis | Lipid metabolism | Cerebrospinal fluid | Cholesterol | Sclerosis | Bile | Index Medicus | nuclear receptors | Patient-Oriented and Epidemiological Research | LXR | biosynthesis | bile acids and salts
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7412, pp. 499 - 503
Journal Article
Science, ISSN 0036-8075, 2/2009, Volume 323, Issue 5918, pp. 1208 - 1211
Journal Article