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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 188 - 200
The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old, has not been... 
CLEARANCE | TISSUE DISTRIBUTION | IN-VIVO | VOLUME | ONTOGENY | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | SIMULATION | DESLORATADINE | EXPOSURE | Humans | Anti-Asthmatic Agents - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Sufentanil - metabolism | Bronchodilator Agents - metabolism | Quinolines - pharmacokinetics | Theophylline - pharmacokinetics | Esomeprazole - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Ondansetron - metabolism | Child | Cytochrome P-450 CYP2C9 - metabolism | Histamine H1 Antagonists, Non-Sedating - pharmacokinetics | Infant, Newborn | Itraconazole - metabolism | Serotonin Antagonists - pharmacokinetics | Tramadol - pharmacokinetics | Theophylline - metabolism | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Proton Pump Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Serotonin Antagonists - metabolism | Analgesics, Opioid - metabolism | Diclofenac - metabolism | Lansoprazole - pharmacokinetics | Loratadine - pharmacokinetics | Sufentanil - pharmacokinetics | Infant | Anti-Asthmatic Agents - pharmacokinetics | Itraconazole - pharmacokinetics | Antifungal Agents - pharmacokinetics | Antifungal Agents - metabolism | Loratadine - metabolism | Cytochrome P-450 CYP2C8 - metabolism | Lansoprazole - metabolism | Acetates - metabolism | Esomeprazole - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Ondansetron - pharmacokinetics | Tramadol - metabolism | Diclofenac - pharmacokinetics | Quinolines - metabolism | Pharmaceutical Preparations - metabolism | Proton Pump Inhibitors - pharmacokinetics | Bronchodilator Agents - pharmacokinetics | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2C19 - metabolism | Loratadine - analogs & derivatives | Histamine H1 Antagonists, Non-Sedating - metabolism | Pharmacokinetics | Acetates - pharmacokinetics
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 8/2017, Volume 56, Issue 8, pp. 893 - 913
Dexmedetomidine is an α2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | ISCHEMIA-REPERFUSION INJURY | MINIMUM ALVEOLAR CONCENTRATION | INCREASING PLASMA-CONCENTRATIONS | POPULATION PHARMACOKINETICS | INTRAVENOUS DEXMEDETOMIDINE | INTRANASAL DEXMEDETOMIDINE | DOUBLE-BLIND | BRACHIAL-PLEXUS BLOCK | PHARMACOLOGY & PHARMACY | INTRAMUSCULAR DEXMEDETOMIDINE | INTENSIVE-CARE | Cardiac Output - physiology | Pediatrics | Intensive Care Units - standards | Analgesics, Non-Narcotic - pharmacokinetics | Hypnotics and Sedatives - adverse effects | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Humans | Hypnotics and Sedatives - administration & dosage | Male | Administration, Buccal | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Adrenergic alpha-2 Receptor Agonists - adverse effects | Analgesics, Non-Narcotic - adverse effects | Hypertension - chemically induced | Adult | Anesthesia | Female | Receptors, GABA - drug effects | Body Mass Index | Dexmedetomidine - administration & dosage | Hypnotics and Sedatives - pharmacokinetics | Dexmedetomidine - pharmacokinetics | Analgesics, Non-Narcotic - administration & dosage | Hypotension - chemically induced | Administration, Intranasal | Dexmedetomidine - adverse effects | Bradycardia - chemically induced | Serum Albumin, Human - physiology | Liver - physiology | Hemodynamics - drug effects | Infusions, Intravenous | Care and treatment | Analysis | Depression, Mental | Dexmedetomidine | Pharmacology | Dosage and administration | Pharmacokinetics | Systematic review | Kinases | Rodents | Review
Journal Article
Journal Article
Archives of Disease in Childhood, ISSN 0003-9888, 06/2019, Volume 104, Issue 6, pp. e2 - e3
BackgroundLittle is known about the pharmacokinetics (PK) of acetaminophen during different stages of pregnancy. The aim of this study was to develop a... 
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 5/2017, Volume 34, Issue 5, pp. 1125 - 1133
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
Journal Article