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Current medicinal chemistry, ISSN 0929-8673, 01/2012, Volume 19, Issue 2, pp. 239 - 280
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in... 
Triazole | Antifungal | Antidiabetic | Triazolium | Anticonvulsant | Antibacterial | Antihistaminic | Antitubercular | Analgesic | Anti-obesitic | Antiparasitic | Antiviral | Anticancer | Anti-inflammatory | Anti-neuropathic | A ADENOSINE RECEPTOR | analgesic | antibacterial | anticancer | triazole | CLICK CHEMISTRY APPROACH | antihistaminic | ANTIBACTERIAL ACTIVITY | anti-inflammatory | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | anti-neuropathic | CHEMISTRY, MEDICINAL | INOSINE MONOPHOSPHATE DEHYDROGENASE | anticonvulsant | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENT SYNTHESIS | PHARMACOLOGICAL IN-VITRO | AZOLE ANTIFUNGAL AGENTS | antitubercular | anti-obesitic | triazolium | antiviral | antiparasitic | antidiabetic | HISTONE DEACETYLASE INHIBITORS | ANTIMICROBIAL ACTIVITY | Antifungal Agents - pharmacology | Analgesics - pharmacology | Antiviral Agents - pharmacology | Antitubercular Agents - chemistry | Anti-Inflammatory Agents - pharmacology | Triazoles - chemistry | Antitubercular Agents - pharmacology | Antifungal Agents - chemistry | Hypoglycemic Agents - chemistry | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Hypoglycemic Agents - pharmacology | Triazoles - pharmacology | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Anticonvulsants - chemistry | Antiparasitic Agents - pharmacology | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Antiparasitic Agents - chemistry
Journal Article
Journal Article
Clinical pharmacology and therapeutics, ISSN 1532-6535, 2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
TRIPTANS SEROTONIN | METAANALYSIS | DOSE-RESPONSE | INTEGRATION | 5-HT1B/1D AGONISTS | PHARMACOLOGY & PHARMACY | SIMULATION | MIGRAINE | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2005, Volume 102, Issue 52, pp. 19144 - 19149
Central nervous system responses to cannabis are primarily mediated by CB 1 receptors, which couple preferentially to G i/o G proteins. Here, we used calcium... 
Aminoalkylindole | Inositol phosphate | Neurons | Phospholipase C | Analgesics - pharmacology | Calcium - metabolism | Humans | Endoplasmic Reticulum - metabolism | Type C Phospholipases - metabolism | Cytoplasm - metabolism | Benzoxazines | Arachidonic Acids - chemistry