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JAMA - Journal of the American Medical Association, ISSN 0098-7484, 03/2018, Volume 319, Issue 9, pp. 872 - 882
IMPORTANCE Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. OBJECTIVE To compare... 
SAMPLE CHARACTERISTICS | MEDICINE, GENERAL & INTERNAL | MUSCULOSKELETAL PAIN | OF-HEALTH PATHWAYS | THERAPY | MANAGEMENT | PRESCRIPTION | PRIMARY-CARE PATIENTS | OUTCOMES | CHRONIC NONCANCER PAIN | PREVENTION WORKSHOP | Chronic Pain - drug therapy | Humans | Middle Aged | Osteoarthritis, Hip - drug therapy | Analgesics, Opioid - therapeutic use | Male | Analgesics, Non-Narcotic - therapeutic use | Back Pain - drug therapy | Young Adult | Analgesics, Opioid - adverse effects | Osteoarthritis, Knee - complications | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Analgesics, Non-Narcotic - adverse effects | Intention to Treat Analysis | Aged, 80 and over | Osteoarthritis, Hip - complications | Adult | Female | Aged | Acetaminophen - therapeutic use | Drug Therapy, Combination | Pain Measurement | Chronic Pain - etiology | Osteoarthritis, Knee - drug therapy | Treatment outcome | Usage | Analgesics | Analysis | Opioids | Diagnosis | Comparative analysis | Backache | Osteoarthritis | Knee | Health care | Drugs | Therapy | Back pain | Narcotics | Oxycodone | Interference | Clinical trials | Morphine | Arthritis | Knee (anatomy) | Inflammation | Patients | Hip | Paracetamol | Randomization | Pain | Acetaminophen | Pain management | Biocompatibility | Drug therapy | Index Medicus | Abridged Index Medicus | Original Investigation | Research
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 539 - 550
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns... 
MEDICINE, RESEARCH & EXPERIMENTAL | DANGER SIGNALS | STERILE INFLAMMATION | CHROMATIN PROTEIN HMGB1 | IN-VIVO | SEPTIC SHOCK | MOBILITY GROUP BOX-1 | RECEPTOR | DEFICIENT MICE | CELL-DEATH | TRANSGENIC MICE | Acetaminophen - adverse effects | Inflammation - chemically induced | Leukocyte Elastase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Tumor Necrosis Factor-alpha - genetics | Analgesics, Non-Narcotic - pharmacology | Hepatocytes - pathology | Hepatocytes - metabolism | Neutrophil Infiltration | fas Receptor - metabolism | Necrosis - pathology | HMGB1 Protein - genetics | Shock, Septic - metabolism | Inflammation - metabolism | Acetaminophen - pharmacology | Analgesics, Non-Narcotic - adverse effects | HMGB1 Protein - metabolism | fas Receptor - genetics | Chemical and Drug Induced Liver Injury - pathology | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Neutrophils - pathology | Shock, Septic - genetics | Shock, Septic - pathology | Lipopolysaccharides - toxicity | Macrophages - pathology | Shock, Septic - chemically induced | Leukocyte Elastase - genetics | Necrosis - metabolism | Chemical and Drug Induced Liver Injury - genetics | Mice, Knockout | Necrosis - chemically induced | Macrophages - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Inflammation - genetics | Mice | Necrosis - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Physiological aspects | Causes of | Inflammation | Genetic aspects | Cell death | Necrosis | Chromosomal proteins | Mass spectrometry | Analysis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 01/2015, Volume 61, Issue 1, pp. 348 - 360
Journal Article
Journal Article