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Nature (London), ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by... 
E3 LIGASE | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | CONJUGATING ENZYME | CHAIN ELONGATION | REVEALS | SUBUNIT | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 17, pp. 5272 - 5279
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 533, Issue 7602, pp. 260 - 264
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 513, Issue 7518, pp. 388 - 393
Journal Article
Journal of molecular biology, ISSN 0022-2836, 11/2013, Volume 425, Issue 22, pp. 4236 - 4248
The anaphase-promoting complex or cyclosome (APC/C) is a large E3 RING-cullin ubiquitin ligase composed of between 14 and 15 individual proteins. A striking... 
anaphase-promoting complex | crystallography | tetratricopeptide repeat (TPR) | single-particle electron microscopy | cell cycle | PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DESTRUCTION BOX | 26S PROTEASOME | SOFTWARE | SUBSTRATE RECOGNITION | MITOSIS | MITOTIC CHECKPOINT COMPLEX | KEN BOX | Amino Acid Sequence | Protein Subunits | Schizosaccharomyces pombe Proteins - chemistry | Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Humans | Protein Multimerization | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Models, Molecular | Molecular Sequence Data | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Minichromosome Maintenance Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - metabolism | Sequence Alignment | Protein Conformation | Protein Interaction Domains and Motifs | Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin | Ligases | Analysis | Structure | Crystals | Proteins | EM, electron microscopy | PDB, Protein Data Bank | SAD, single-wavelength anomalous dispersion | APC | TPR, tetratricopeptide repeat | FOM, figure of merit | C, anaphase-promoting complex or cyclosome
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 01/2011, Volume 18, Issue 1, pp. 6 - 13
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2016, Volume 352, Issue 6289, pp. 1121 - 1124
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2019, Volume 218, Issue 4, pp. 1265 - 1281
Journal Article