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Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 450 - 454
The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit. Its regulation by... 
E3 LIGASE | SPINDLE CHECKPOINT | ANAPHASE-PROMOTING COMPLEX | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MITOTIC REGULATION | EM STRUCTURE DETERMINATION | CRYO-EM | ELECTRON-MICROSCOPY | CONJUGATING ENZYME | CHAIN ELONGATION | Phosphorylation | Ubiquitin - ultrastructure | Cadherins - metabolism | Humans | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin - metabolism | Cell Cycle Proteins - ultrastructure | Substrate Specificity | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cell Cycle Proteins - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitination | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Cadherins - chemistry | Cytoskeletal Proteins - metabolism | Lysine - metabolism | Anaphase-Promoting Complex-Cyclosome - chemistry | Cadherins - ultrastructure | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Catalytic Domain | F-Box Proteins - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin - chemistry | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cytoskeletal Proteins - chemistry | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Cryoelectron Microscopy | F-Box Proteins - ultrastructure | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Protein Subunits - chemistry | Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - ultrastructure | Ubiquitin | Physiological aspects | Structure | Ubiquitin-proteasome system | Ligases | Proteins | Peptides | Molecular structure | Cyclin-dependent kinases | Cell division | Kinases | Gene expression | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7602, pp. 260 - 264
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 17, pp. 5272 - 5279
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 11/2013, Volume 425, Issue 22, pp. 4236 - 4248
The anaphase-promoting complex or cyclosome (APC/C) is a large E3 RING-cullin ubiquitin ligase composed of between 14 and 15 individual proteins. A striking... 
anaphase-promoting complex | crystallography | tetratricopeptide repeat (TPR) | single-particle electron microscopy | cell cycle | PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DESTRUCTION BOX | 26S PROTEASOME | SOFTWARE | SUBSTRATE RECOGNITION | MITOSIS | MITOTIC CHECKPOINT COMPLEX | KEN BOX | Amino Acid Sequence | Protein Subunits | Schizosaccharomyces pombe Proteins - chemistry | Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - chemistry | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Humans | Protein Multimerization | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Models, Molecular | Molecular Sequence Data | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Minichromosome Maintenance Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Schizosaccharomyces - metabolism | Sequence Alignment | Protein Conformation | Protein Interaction Domains and Motifs | Anaphase-Promoting Complex-Cyclosome - chemistry | Ubiquitin | Ligases | Analysis | Structure | Crystals | Proteins | Index Medicus | EM, electron microscopy | PDB, Protein Data Bank | SAD, single-wavelength anomalous dispersion | APC | TPR, tetratricopeptide repeat | FOM, figure of merit | C, anaphase-promoting complex or cyclosome
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 01/2011, Volume 18, Issue 1, pp. 6 - 13
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 388 - 393
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 01/2009, Volume 545, pp. 271 - 285
Cell cycle transitions are controlled, in part, by ubiquitin-dependent proteolysis. In mitosis, the metaphase to anaphase transition is governed by an E3... 
Anaphase
Journal Article
PLoS ONE, 07/2013, Volume 8, Issue 7
IL-17 is the founding member of a family of cytokines and receptors with unique structures and signaling properties. IL-17 is the signature cytokine of Th17... 
Anaphase
Journal Article
PLoS ONE, 06/2013, Volume 8, Issue 6
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been... 
Anaphase
Journal Article
PLoS ONE, 05/2013, Volume 8, Issue 5
Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into... 
Anaphase
Journal Article
PLoS ONE, 03/2013, Volume 8, Issue 3
Neuroblastomas (NBs) are tumours of the sympathetic nervous system accounting for 8-10% of paediatric cancers. NBs exhibit extensive intertumour genetic... 
Anaphase
Journal Article
PLoS ONE, 03/2013, Volume 8, Issue 3
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting... 
Anaphase
Journal Article
by Sik, L and Acar, O and Aki, C
African Journal of Biotechnology, ISSN 1684-5315, 05/2009, Volume 8, Issue 9, pp. 1919 - 1925
The aim of this research is to study the effects of different concentrations of water on both incoming and outgoing in central biological and chemical... 
Anaphase
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 431 - 436
In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daughter cell inherits an identical set of chromosomes. The SAC... 
MAD2 | ANAPHASE-PROMOTING COMPLEX | MECHANISM | CDC20 BINDING | UCSF CHIMERA | PHOSPHORYLATION | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | RECOMBINANT EXPRESSION | MITOTIC CHECKPOINT | SACCHAROMYCES-CEREVISIAE | Spindle Apparatus - chemistry | Humans | Protein-Serine-Threonine Kinases - ultrastructure | Structure-Activity Relationship | Anaphase-Promoting Complex-Cyclosome - antagonists & inhibitors | Anaphase-Promoting Complex-Cyclosome - ultrastructure | Protein Subunits - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | Ubiquitination | Spindle Apparatus - metabolism | Cdc20 Proteins - chemistry | Anaphase-Promoting Complex-Cyclosome - chemistry | Spindle Apparatus - ultrastructure | Protein-Serine-Threonine Kinases - metabolism | Cdc20 Proteins - ultrastructure | Chromosome Segregation | Biocatalysis | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Ubiquitin-Conjugating Enzymes - ultrastructure | Cryoelectron Microscopy | Ubiquitin-Conjugating Enzymes - metabolism | Cdc20 Proteins - metabolism | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Protein-Serine-Threonine Kinases - chemistry | Anaphase-Promoting Complex-Cyclosome - metabolism | M Phase Cell Cycle Checkpoints - physiology | Spindle (Cell division) | Physiological aspects | Research | Molecular biology | Ligases | Cell division | Kinases | Chromosomes | Binding sites | Crystal structure | Index Medicus
Journal Article