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The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | Molecules | Genes | Index Medicus | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | Proteins | Genes | Index Medicus | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
New Phytologist, ISSN 0028-646X, 9/2015, Volume 207, Issue 4, pp. 1061 - 1074
Stress-activated plant mitogen-activated protein (MAP) kinase pathways play roles in growth adaptation to the environment by modulating cell division through... 
Proteins | Full Papers | Microtubules | Kinetochores | Antibodies | Cell division | Gene expression regulation | Signals | Arrows | Anaphase | Chromosomes | nitrosative stress | Arabidopsis | cell division | MPK | γ‐tubulin | microtubules | mitogen‐activated protein kinase | γ-tubulin | Mitogen-activated protein kinase | MPK6 | Nitrosative stress | EB1c | Tyrosine - pharmacology | Meristem - cytology | Telophase - drug effects | Arabidopsis - enzymology | Nitriles - pharmacology | Microtubule-Associated Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Chromosome Segregation - drug effects | Tyrosine - analogs & derivatives | Arabidopsis Proteins - metabolism | Microtubules - metabolism | Tubulin - metabolism | Spindle Apparatus - metabolism | Microtubules - drug effects | Meristem - metabolism | Stress, Physiological - drug effects | Meristem - drug effects | Phosphorylation - drug effects | Cytokinesis - drug effects | Butadienes - pharmacology | Arabidopsis - drug effects | Plant Cells - metabolism | Kinetochores - metabolism | Arabidopsis - cytology | Anaphase - drug effects | Nitrosation - drug effects | Plant Cells - drug effects | Cell Proliferation - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal Article
by Fu, AKY and Hung, KW and Fu, WY and Shen, C and Chen, Y and Xia, J and Lai, KO and Ip, NY
NATURE NEUROSCIENCE, ISSN 1097-6256, 02/2011, Volume 14, Issue 2, pp. 181 - U263
Homeostatic plasticity is crucial for maintaining neuronal output by counteracting unrestrained changes in synaptic strength. Chronic elevation of synaptic... 
ANAPHASE-PROMOTING COMPLEX | DENDRITIC SPINE MORPHOGENESIS | GLUTAMATE RECEPTORS | UBIQUITIN-PROTEASOME SYSTEM | EPHB RECEPTORS | PROTEIN-DEGRADATION | EXCITATORY SYNAPSES | SURFACE EXPRESSION | SYNAPTIC PLASTICITY | NEUROSCIENCES | POSTSYNAPTIC DENSITY | Anaphase-Promoting Complex-Cyclosome | Electrophysiology | Neuronal Plasticity - drug effects | Receptor, EphA4 - metabolism | Neurons - cytology | Ubiquitin-Protein Ligase Complexes - genetics | Hippocampus - drug effects | Miniature Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Neuronal Plasticity - physiology | Ubiquitination - drug effects | Neurons - physiology | Statistics, Nonparametric | Ubiquitination - physiology | Neurons - drug effects | Receptors, AMPA - genetics | Receptors, AMPA - metabolism | GABA-A Receptor Antagonists - pharmacology | Miniature Postsynaptic Potentials - physiology | Synapses - drug effects | Synapses - physiology | Cells, Cultured | Bicuculline - pharmacology | Down-Regulation - drug effects | Hippocampus - cytology | Down-Regulation - physiology | Proteasome Endopeptidase Complex - genetics | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Analysis of Variance | RNA, Small Interfering | Proteasome Endopeptidase Complex - metabolism | Hippocampus - physiology | Index Medicus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 239 - 242
Non-small-cell lung cancer is the leading cause of cancer-related death worldwide(1). Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide... 
ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | COMPLEXES | SWI/SNF | GROWTH | GENE-EXPRESSION | ANTAGONISM | MUTATIONS | CANCER | POLYCOMB | MICROARRAY DATA | Polycomb Repressive Complex 2 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - pathology | Molecular Targeted Therapy | Antineoplastic Agents, Phytogenic - therapeutic use | Nuclear Proteins - genetics | DNA Helicases - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Genes, erbB-1 - genetics | Etoposide - pharmacology | Etoposide - therapeutic use | Topoisomerase II Inhibitors - pharmacology | Transcription Factors - genetics | Anaphase - drug effects | Enhancer of Zeste Homolog 2 Protein | Topoisomerase II Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Protein research | Care and treatment | Oncology, Experimental | Genetic aspects | Research | Lung cancer, Non-small cell | Drug therapy | Gene expression | Cancer | Proteins | Genes | Lung cancer | Genetic engineering | Mutation | Kinases | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Etoposide | Chemotherapy | EZH2 inhibition | BRG1 | EGFR
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 35, pp. 14311 - 14324
The interconnected PI3K and MAPK signaling pathways are commonly perturbed in cancer. Dual inhibition of these pathways by the small-molecule PI3K inhibitor... 
APOPTOSIS | ANAPHASE-PROMOTING COMPLEX | PROTEIN | INHIBITION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBIQUITYLATION | PROTEOLYSIS | IDENTIFICATION | TUMOR-GROWTH | SUBSTRATE RECOGNITION | Cadherins - metabolism | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Melanoma - enzymology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Enzyme Stability - drug effects | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Cadherins - genetics | Neoplasm Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | Melanoma - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Cyclin-Dependent Kinase 2 - genetics | Neoplasm Proteins - chemistry | Melanoma - pathology | Recombinant Fusion Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | Point Mutation | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Melanoma - drug therapy | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cadherins - antagonists & inhibitors | Cell Proliferation - drug effects | S Phase - drug effects | Ubiquitin-Protein Ligases - genetics | Amino Acid Substitution | Index Medicus | cyclin | Signal Transduction | PIK3CA | cell cycle | cell signaling | CDK2 | melanoma | E3 ubiquitin ligase | MAPK
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2012, Volume 109, Issue 33, pp. E2205 - E2214
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2016, Volume 18, Issue 5, pp. 516 - 526
Journal Article