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Molecular Immunology, ISSN 0161-5890, 2008, Volume 45, Issue 14, pp. 3767 - 3774
There is now strong evidence for non-immune or inflammatory functions of complement, notably in the central nervous system. In particular, it has been recently... 
Cerebellum | Development | Complement | Anaphylatoxin | MIGRATION | CYCLASE-ACTIVATING POLYPEPTIDE | development | MESSENGER-RNA EXPRESSION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURODEGENERATION | IMMUNOLOGY | cerebellum | CELL-DEATH | HUMAN ASTROCYTES | LIVER-REGENERATION | NEURONS | COMPONENT | complement | anaphylatoxin | Immunohistochemistry | Receptor, Anaphylatoxin C5a - agonists | Rats, Wistar | Apoptosis - drug effects | Cells, Cultured | Neurons - immunology | Rats | Receptors, Complement - agonists | Receptors, Complement - metabolism | Receptors, G-Protein-Coupled - immunology | Cell Movement - drug effects | Neurons - classification | Animals | Receptors, Complement - immunology | Anaphylatoxins - metabolism | Cerebellum - cytology | Receptor, Anaphylatoxin C5a - immunology | Cerebellum - growth & development | Cell Proliferation - drug effects | Neurons - metabolism | Anaphylatoxins - pharmacology | Receptor, Anaphylatoxin C5a - metabolism | Brain | Complement receptors | Neonates | Histogenesis | Granule cells | Central nervous system | Anaphylatoxins | Antagonists | Inflammation | complement component C3a | Cell migration | Cell Proliferation | Neurons | Neurons and Cognition | Receptors, G-Protein-Coupled | Neurobiology | Pharmacology | Cellular Biology | Chemical Sciences | Receptors, Complement | Medicinal Chemistry | Life Sciences | Receptor, Anaphylatoxin C5a | Pharmaceutical sciences | Apoptosis | Cell Movement | Cell Behavior
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 541 - 548.e9
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 10, pp. 7633 - 7644
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7686, pp. 111 - 114
The complement system is a crucial component of the host response to infection and tissue damage. Activation of the complement cascade generates anaphylatoxins... 
ACID | SMALL-MOLECULE | OPIOID RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GPCR | OLIGOMERIZATION | IDENTIFICATION | Receptor, Anaphylatoxin C5a - chemistry | Receptor, Anaphylatoxin C5a - genetics | Protein Structure, Secondary | Receptors, G-Protein-Coupled - metabolism | Humans | Imidazoles - chemistry | Benzodioxoles - metabolism | Models, Molecular | Crystallography, X-Ray | Imidazoles - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Animals | Drug Inverse Agonism | HEK293 Cells | Benzodioxoles - chemistry | Mutation | Protein Stability | Receptor, Anaphylatoxin C5a - antagonists & inhibitors | Binding Sites | Benzodioxoles - pharmacology | Receptors, G-Protein-Coupled - chemistry | Imidazoles - metabolism | Receptor, Anaphylatoxin C5a - metabolism | Drugs | Inflammatory bowel diseases | G protein-coupled receptors | Peptides | Complement component C5a | Manufacturing engineering | Complement | Antagonists | Helices | Arthritis | Production costs | Receptors | Reperfusion | Ischemia | Anaphylatoxins | Alzheimer's disease | Neurodegenerative diseases | Psoriasis | Medical treatment | Crystallization | Inflammation | Crohn's disease | Bioavailability | Mode of action | Complement activation | Immunogenicity | Rheumatoid arthritis | Sepsis | Ligands
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 02/2008, Volume 86, Issue 2, pp. 153 - 160
Journal Article
Science, ISSN 0036-8075, 06/2016, Volume 352, Issue 6292, pp. aad1210 - aad1210
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2015, Volume 35, Issue 16, pp. 6517 - 6531
This study investigated the role of the complement activation fragment C5a in secondary pathology following contusive spinal cord injury (SCI). C5ar(-/-) mice,... 
Demyelinating pathology | Anaphylatoxin | Secondary degeneration | CNS trauma | Macrophage | Oligodendrocyte precursor cell | FUNCTIONAL RECOVERY | POLYMORPHONUCLEAR LEUKOCYTES | GLIAL SCAR | macrophage | NEUROSCIENCES | RAT MODEL | oligodendrocyte precursor cell | secondary degeneration | demyelinating pathology | IN-VIVO | REACTIVE ASTROCYTES | LESION DEVELOPMENT | CHOROID-PLEXUS | DUAL ROLE | anaphylatoxin | INTERLEUKIN-8 IL-8 | Receptor, Anaphylatoxin C5a - genetics | Inflammation - pathology | Motor Activity - physiology | Spinal Cord Injuries - drug therapy | Spinal Cord Injuries - complications | Motor Activity - drug effects | Peptides, Cyclic - pharmacology | Gliosis - physiopathology | Complement C5a - biosynthesis | Gliosis - pathology | Inflammation - complications | Inflammation - drug therapy | Recovery of Function - physiology | Female | Complement Activation - drug effects | Complement Activation - physiology | Spinal Cord Injuries - metabolism | Cell Proliferation - physiology | Cells, Cultured | Gliosis - complications | Mice, Knockout | Astrocytes - physiology | Receptor, Anaphylatoxin C5a - physiology | Animals | Peptides, Cyclic - therapeutic use | Cell Proliferation - drug effects | Gliosis - drug therapy | Mice | Receptor, Anaphylatoxin C5a - biosynthesis | Spinal Cord Injuries - physiopathology | Receptor, Anaphylatoxin C5a - antagonists & inhibitors | Inflammation - physiopathology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2007, Volume 27, Issue 32, pp. 8699 - 8708
Journal Article
Molecular Immunology, ISSN 0161-5890, 09/2009, Volume 46, Issue 14, pp. 2753 - 2766
Journal Article