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Molecular cancer research, ISSN 1541-7786, 04/2016, Volume 14, Issue 4, pp. 324 - 331
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Triazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Acetanilides - administration & dosage | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Receptors, Androgen - metabolism | Male | Androgen Receptor Antagonists - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Phenylthiohydantoin - pharmacology | Cell Survival - drug effects | Acetanilides - pharmacology | Androgen Receptor Antagonists - administration & dosage | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Phenylthiohydantoin - analogs & derivatives | Azepines - pharmacology | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Phenylthiohydantoin - administration & dosage | Animals | Signal Transduction - drug effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Azepines - administration & dosage | Drug Resistance, Neoplasm - drug effects | Index Medicus
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Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 787 - 790
COS cells | Androgens | Cell lines | Agonists | Oncology | Reports | Androgen antagonists | Prostate cancer | Heterologous transplantation | Tumors | Vehicles | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Chemotherapy | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Transcription, Genetic - drug effects | Nitriles - pharmacology | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Biological Availability | Male | Antineoplastic Agents - therapeutic use | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Cell Nucleus - metabolism | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Androgen Antagonists - pharmacokinetics | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Androgen Antagonists - metabolism | Androgen Antagonists - pharmacology | Anilides - metabolism | DNA - metabolism | Phenylthiohydantoin - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Anilides - pharmacology | Tosyl Compounds - metabolism | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylthiohydantoin - metabolism | Drug Screening Assays, Antitumor | Phenylthiohydantoin - pharmacokinetics | Care and treatment | Antiandrogens | Dosage and administration | Drug therapy | Methods | Cancer | Pharmacology | Binding sites | Index Medicus
Journal Article
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 11/2009, Volume 124, Issue 2, pp. 195 - 206
Depression | Stroke | Cocaine | Pain | Sigma-1 receptor | Cancer | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Behavior, Addictive - drug therapy | Humans | Nervous System Diseases - drug therapy | Analgesics, Opioid - pharmacology | Analgesics, Opioid - therapeutic use | Receptors, sigma - agonists | Receptors, sigma - antagonists & inhibitors | Behavior, Addictive - metabolism | Ion Channel Gating - physiology | Animals | Narcotic Antagonists - therapeutic use | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Nervous System Diseases - metabolism | Signal Transduction - physiology | Receptors, sigma - metabolism | Ion Channel Gating - drug effects | Methyl aspartate | Nervous system diseases | Dehydroepiandrosterone | Androgens | Molecular chaperones | Heterocyclic compounds | Depression, Mental | HIV (Viruses) | HIV infection | Alzheimer's disease | Index Medicus | pain | cancer | depression | cocaine | stroke
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 7, pp. 2779 - 2796
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prostatic Neoplasms - pathology | Androgen Receptor Antagonists | Prostatic Neoplasms - surgery | Thiohydantoins - pharmacology | Receptors, Androgen - metabolism | Male | Structure-Activity Relationship | Thiohydantoins - chemical synthesis | Orchiectomy | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | Androgens | Animals | Prostatic Neoplasms - genetics | Tumor Burden - drug effects | Thiohydantoins - therapeutic use | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | Thiohydantoins - chemistry | Prostatic Neoplasms - drug therapy | Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 2948 - 2960
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Prostatic Neoplasms - metabolism | Stereoisomerism | Humans | Receptors, Androgen - metabolism | Transcriptional Activation - drug effects | Cercopithecus aethiops | Male | Androgen Receptor Antagonists - pharmacology | Benzhydryl Compounds - chemistry | Luciferases - genetics | Androgen Receptor Antagonists - chemistry | Receptors, Androgen - chemistry | Chlorohydrins - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Genes, Reporter | Prostatic Neoplasms - drug therapy | Protein Structure, Tertiary | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Click Chemistry | Mice, SCID | Chlorohydrins - chemistry | Orchiectomy | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Tumor Burden - drug effects | Protein Binding | Mice, Inbred NOD | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Hormonal - chemistry | COS Cells | Luciferases - biosynthesis | Antagonists (Biochemistry) | Care and treatment | Androgens | Physiological aspects | Prostate cancer | Health aspects | Methods | Cancer | Proteins | Medical research | Ligands | Kinases | Gene expression | Experiments | Drug dosages | Tumors | Index Medicus | Abridged Index Medicus
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Endocrine-related cancer, ISSN 1351-0088, 08/2014, Volume 21, Issue 4, pp. T105 - T118
Thematic Review | Antiandrogen | Bicalutamide | Androgen receptor antagonist | Enzalutamide | Abiraterone | Prostate cancer | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Prostatic Neoplasms - metabolism | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Male | Antineoplastic Agents - therapeutic use | Androgen Receptor Antagonists - pharmacology | Antineoplastic Agents - chemistry | Animals | Castration | Androgen Receptor Antagonists - chemistry | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 11/2020, Volume 63, Issue 21, pp. 12642 - 12665
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prostatic Neoplasms - metabolism | Pyrazoles - therapeutic use | Androgen Receptor Antagonists - therapeutic use | Phenylthiohydantoin - therapeutic use | Humans | Microsomes, Liver - metabolism | Receptors, Androgen - metabolism | Half-Life | Male | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Androgen Receptor Antagonists - pharmacology | Pyrazoles - chemistry | Androgen Receptor Antagonists - chemistry | Drug Design | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Pyrazoles - pharmacology | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Rats | Rats, Sprague-Dawley | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2008, Volume 68, Issue 18, pp. 7475 - 7483
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | RNA, Small Interfering - genetics | Up-Regulation | Humans | Receptors, Androgen - metabolism | Cell Growth Processes - physiology | Male | Immediate-Early Proteins - metabolism | RNA, Messenger - biosynthesis | Prostatic Neoplasms - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Metribolone - pharmacology | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Prostatic Neoplasms - pathology | Immediate-Early Proteins - biosynthesis | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Immediate-Early Proteins - genetics | Benzoates - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Immediate-Early Proteins - antagonists & inhibitors | Index Medicus | prostate cancer | androgen receptor | serum and glucocorticoid-regulated kinase 1
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Blood, ISSN 0006-4971, 2009, Volume 114, Issue 11, pp. 2236 - 2243
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Gene Expression Regulation, Enzymologic - drug effects | Androgen Receptor Antagonists | Estrogens - pharmacology | Dyskeratosis Congenita - drug therapy | Nitriles - pharmacology | Aromatase Inhibitors - pharmacology | Humans | Receptors, Androgen - metabolism | Hematopoietic Stem Cells - pathology | Estrogen Antagonists - pharmacology | Male | Dyskeratosis Congenita - genetics | Anemia, Aplastic - enzymology | Estrogens - therapeutic use | Estrogen Receptor alpha | Telomerase - genetics | Androgens - therapeutic use | Female | Anemia, Aplastic - genetics | Estradiol - pharmacology | Estradiol - therapeutic use | Androgen Antagonists - pharmacology | Dyskeratosis Congenita - enzymology | Flutamide - pharmacology | Triazoles - pharmacology | Telomerase - biosynthesis | Androgens - pharmacology | Anemia, Aplastic - drug therapy | Tamoxifen - pharmacology | Lymphocytes - enzymology | Heterozygote | Mutation | Hematopoietic Stem Cells - enzymology | Index Medicus | Abridged Index Medicus | Hematopoiesis and Stem Cells
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