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1. Full Text BET bromodomain inhibitors enhance efficacy and disrupt resistance to AR antagonists in the treatment of prostate cancer
by Asangani, Irfan A and Wilder-Romans, Kari and Dommeti, Vijaya L and Krishnamurthy, Pranathi M and Apel, Ingrid J and Escara-Wilke, June and Plymate, Stephen R and Navone, Nora M and Wang, Shaomeng and Feng, Felix Y and Chinnaiyan, Arul M
Molecular cancer research, ISSN 1541-7786, 04/2016, Volume 14, Issue 4, pp. 324 - 331
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Triazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Acetanilides - administration & dosage | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Receptors, Androgen - metabolism | Male | Androgen Receptor Antagonists - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Phenylthiohydantoin - pharmacology | Cell Survival - drug effects | Acetanilides - pharmacology | Androgen Receptor Antagonists - administration & dosage | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Phenylthiohydantoin - analogs & derivatives | Azepines - pharmacology | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Phenylthiohydantoin - administration & dosage | Animals | Signal Transduction - drug effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Azepines - administration & dosage | Drug Resistance, Neoplasm - drug effects | Index Medicus
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2. Full Text Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
by Chris Tran and Samedy Ouk and Nicola J. Clegg and Yu Chen and Philip A. Watson and Vivek Arora and John Wongvipat and Peter M. Smith-Jones and Dongwon Yoo and Andrew Kwon and Teresa Wasielewska and Derek Welsbie and Charlie Degui Chen and Celestia S. Higano and Tomasz M. Beer and David T. Hung and Howard I. Scher and Michael E. Jung and Charles L. Sawyers
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 787 - 790
COS cells | Androgens | Cell lines | Agonists | Oncology | Reports | Androgen antagonists | Prostate cancer | Heterologous transplantation | Tumors | Vehicles | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Chemotherapy | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Transcription, Genetic - drug effects | Nitriles - pharmacology | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Biological Availability | Male | Antineoplastic Agents - therapeutic use | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Cell Nucleus - metabolism | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Androgen Antagonists - pharmacokinetics | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Androgen Antagonists - metabolism | Androgen Antagonists - pharmacology | Anilides - metabolism | DNA - metabolism | Phenylthiohydantoin - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Anilides - pharmacology | Tosyl Compounds - metabolism | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylthiohydantoin - metabolism | Drug Screening Assays, Antitumor | Phenylthiohydantoin - pharmacokinetics | Care and treatment | Antiandrogens | Dosage and administration | Drug therapy | Methods | Cancer | Pharmacology | Binding sites | Index Medicus
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3. Full Text The pharmacology of sigma-1 receptors
by Maurice, Tangui and Su, Tsung-Ping
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 11/2009, Volume 124, Issue 2, pp. 195 - 206
Depression | Stroke | Cocaine | Pain | Sigma-1 receptor | Cancer | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Behavior, Addictive - drug therapy | Humans | Nervous System Diseases - drug therapy | Analgesics, Opioid - pharmacology | Analgesics, Opioid - therapeutic use | Receptors, sigma - agonists | Receptors, sigma - antagonists & inhibitors | Behavior, Addictive - metabolism | Ion Channel Gating - physiology | Animals | Narcotic Antagonists - therapeutic use | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Nervous System Diseases - metabolism | Signal Transduction - physiology | Receptors, sigma - metabolism | Ion Channel Gating - drug effects | Methyl aspartate | Nervous system diseases | Dehydroepiandrosterone | Androgens | Molecular chaperones | Heterocyclic compounds | Depression, Mental | HIV (Viruses) | HIV infection | Alzheimer's disease | Index Medicus | pain | cancer | depression | cocaine | stroke
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4. Full Text Structure−Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)
by Jung, Michael E and Ouk, Samedy and Yoo, Dongwon and Sawyers, Charles L and Chen, Charlie and Tran, Chris and Wongvipat, John
Journal of medicinal chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 7, pp. 2779 - 2796
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prostatic Neoplasms - pathology | Androgen Receptor Antagonists | Prostatic Neoplasms - surgery | Thiohydantoins - pharmacology | Receptors, Androgen - metabolism | Male | Structure-Activity Relationship | Thiohydantoins - chemical synthesis | Orchiectomy | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | Androgens | Animals | Prostatic Neoplasms - genetics | Tumor Burden - drug effects | Thiohydantoins - therapeutic use | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | Thiohydantoins - chemistry | Prostatic Neoplasms - drug therapy | Index Medicus
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5. Full Text An androgen receptor N-terminal domain antagonist for treating prostate cancer
by Myung, Jae-Kyung and Banuelos, Carmen A and Fernandez, Javier Garcia and Mawji, Nasrin R and Wang, Jun and Tien, Amy H and Yang, Yu Chi and Tavakoli, Iran and Haile, Simon and Watt, Kate and McEwan, Iain J and Plymate, Stephen and Andersen, Raymond J and Sadar, Marianne D
The Journal of clinical investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 2948 - 2960
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Prostatic Neoplasms - metabolism | Stereoisomerism | Humans | Receptors, Androgen - metabolism | Transcriptional Activation - drug effects | Cercopithecus aethiops | Male | Androgen Receptor Antagonists - pharmacology | Benzhydryl Compounds - chemistry | Luciferases - genetics | Androgen Receptor Antagonists - chemistry | Receptors, Androgen - chemistry | Chlorohydrins - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Genes, Reporter | Prostatic Neoplasms - drug therapy | Protein Structure, Tertiary | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Click Chemistry | Mice, SCID | Chlorohydrins - chemistry | Orchiectomy | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Tumor Burden - drug effects | Protein Binding | Mice, Inbred NOD | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Hormonal - chemistry | COS Cells | Luciferases - biosynthesis | Antagonists (Biochemistry) | Care and treatment | Androgens | Physiological aspects | Prostate cancer | Health aspects | Methods | Cancer | Proteins | Medical research | Ligands | Kinases | Gene expression | Experiments | Drug dosages | Tumors | Index Medicus | Abridged Index Medicus
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6. Full Text Androgen receptor antagonists for prostate cancer therapy
by Helsen, Christine and Van den Broeck, Thomas and Voet, Arnout and Prekovic, Stefan and Van Poppel, Hendrik and Joniau, Steven and Claessens, Frank
Endocrine-related cancer, ISSN 1351-0088, 08/2014, Volume 21, Issue 4, pp. T105 - T118
Thematic Review | Antiandrogen | Bicalutamide | Androgen receptor antagonist | Enzalutamide | Abiraterone | Prostate cancer | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Prostatic Neoplasms - metabolism | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Male | Antineoplastic Agents - therapeutic use | Androgen Receptor Antagonists - pharmacology | Antineoplastic Agents - chemistry | Animals | Castration | Androgen Receptor Antagonists - chemistry | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Index Medicus
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7. Full Text Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer
by He, Yali and Hwang, Dong-Jin and Ponnusamy, Suriyan and Thiyagarajan, Thirumagal and Mohler, Michael L and Narayanan, Ramesh and Miller, Duane D
Journal of medicinal chemistry, ISSN 0022-2623, 11/2020, Volume 63, Issue 21, pp. 12642 - 12665
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Prostatic Neoplasms - metabolism | Pyrazoles - therapeutic use | Androgen Receptor Antagonists - therapeutic use | Phenylthiohydantoin - therapeutic use | Humans | Microsomes, Liver - metabolism | Receptors, Androgen - metabolism | Half-Life | Male | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Androgen Receptor Antagonists - pharmacology | Pyrazoles - chemistry | Androgen Receptor Antagonists - chemistry | Drug Design | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Pyrazoles - pharmacology | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Rats | Rats, Sprague-Dawley | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Index Medicus
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8. Full Text Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer
by Li, Zhenfei and Bishop, Andrew C and Alyamani, Mohammad and Garcia, Jorge A and Dreicer, Robert and Bunch, Dustin and Liu, Jiayan and Upadhyay, Sunil K and Auchus, Richard J and Sharifi, Nima
Nature (London), ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
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9. Full Text Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic
by Sherk, Andrea B and Frigo, Daniel E and Schnackenberg, Christine G and Bray, Jeffrey D and Laping, Nicholas J and Trizna, Walter and Hammond, Marlys and Patterson, Jaclyn R and Thompson, Scott K and Kazmin, Dmitri and Norris, John D and McDonnell, Donald P
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2008, Volume 68, Issue 18, pp. 7475 - 7483
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | RNA, Small Interfering - genetics | Up-Regulation | Humans | Receptors, Androgen - metabolism | Cell Growth Processes - physiology | Male | Immediate-Early Proteins - metabolism | RNA, Messenger - biosynthesis | Prostatic Neoplasms - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Metribolone - pharmacology | Prostatic Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Prostatic Neoplasms - pathology | Immediate-Early Proteins - biosynthesis | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Immediate-Early Proteins - genetics | Benzoates - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Immediate-Early Proteins - antagonists & inhibitors | Index Medicus | prostate cancer | androgen receptor | serum and glucocorticoid-regulated kinase 1
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10. Full Text Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
by Calado, Rodrigo T and Yewdell, William T and Wilkerson, Keisha L and Regal, Joshua A and Kajigaya, Sachiko and Stratakis, Constantine A and Young, Neal S
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 11, pp. 2236 - 2243
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Gene Expression Regulation, Enzymologic - drug effects | Androgen Receptor Antagonists | Estrogens - pharmacology | Dyskeratosis Congenita - drug therapy | Nitriles - pharmacology | Aromatase Inhibitors - pharmacology | Humans | Receptors, Androgen - metabolism | Hematopoietic Stem Cells - pathology | Estrogen Antagonists - pharmacology | Male | Dyskeratosis Congenita - genetics | Anemia, Aplastic - enzymology | Estrogens - therapeutic use | Estrogen Receptor alpha | Telomerase - genetics | Androgens - therapeutic use | Female | Anemia, Aplastic - genetics | Estradiol - pharmacology | Estradiol - therapeutic use | Androgen Antagonists - pharmacology | Dyskeratosis Congenita - enzymology | Flutamide - pharmacology | Triazoles - pharmacology | Telomerase - biosynthesis | Androgens - pharmacology | Anemia, Aplastic - drug therapy | Tamoxifen - pharmacology | Lymphocytes - enzymology | Heterozygote | Mutation | Hematopoietic Stem Cells - enzymology | Index Medicus | Abridged Index Medicus | Hematopoiesis and Stem Cells
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