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Journal of Clinical Investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 2948 - 2960
Hormone therapies for advanced prostate cancer target the androgen receptor (AR) ligand-binding domain (LBD), but these ultimately fail and the disease... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNAL-TRANSDUCTION PATHWAYS | CELLS | TRANSCRIPTIONAL ACTIVATION | PROTEIN | ANTIANDROGEN | GENE-EXPRESSION | TRANSACTIVATION DOMAIN | TUMOR-GROWTH | PROGRESSION | HORMONE RECEPTORS | Prostatic Neoplasms - metabolism | Stereoisomerism | Humans | Receptors, Androgen - metabolism | Transcriptional Activation - drug effects | Cercopithecus aethiops | Male | Androgen Receptor Antagonists - pharmacology | Benzhydryl Compounds - chemistry | Luciferases - genetics | Androgen Receptor Antagonists - chemistry | Receptors, Androgen - chemistry | Chlorohydrins - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Genes, Reporter | Prostatic Neoplasms - drug therapy | Protein Structure, Tertiary | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Click Chemistry | Mice, SCID | Chlorohydrins - chemistry | Orchiectomy | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Tumor Burden - drug effects | Protein Binding | Mice, Inbred NOD | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Hormonal - chemistry | COS Cells | Luciferases - biosynthesis | Antagonists (Biochemistry) | Care and treatment | Androgens | Physiological aspects | Prostate cancer | Health aspects | Methods | Cancer | Proteins | Medical research | Ligands | Kinases | Gene expression | Experiments | Drug dosages | Tumors
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2015, Volume 54, Issue 33, pp. 9659 - 9662
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6458 - 6467
The human androgen receptor (AR) is considered as a master regulator in the development and progression of prostate cancer (PCa). As resistance to clinically... 
IN-VITRO | CHEMISTRY, MEDICINAL | ANTIANDROGEN | STRUCTURAL BASIS | 3 BF3 SITE | INCREASED SURVIVAL | RESISTANT PROSTATE-CANCER | CASTRATION-RESISTANT | ANTAGONISTS | SPLICE VARIANTS | ENZALUTAMIDE | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Receptors, Androgen - metabolism | Imidazoles - chemistry | Drug Resistance, Neoplasm | Male | Structure-Activity Relationship | Androgen Receptor Antagonists - pharmacology | Androgen Receptor Antagonists - chemistry | Computer Simulation | Transcription, Genetic | Antineoplastic Agents - pharmacology | Imidazoles - chemical synthesis | Binding Sites | Prostatic Neoplasms - drug therapy | Morpholines - chemical synthesis | Phenylthiohydantoin - pharmacology | Cell Survival - drug effects | Pyrvinium Compounds - chemistry | Prostate-Specific Antigen - secretion | Morpholines - pharmacology | Rats | Thiophenes - pharmacology | Imidazoles - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | Morpholines - chemistry | Phenylthiohydantoin - analogs & derivatives | Thiophenes - chemical synthesis | Animals | Receptors, Androgen - genetics | Thiazoles - chemical synthesis | Databases, Chemical | Androgen Receptor Antagonists - chemical synthesis | Cell Line, Tumor | Thiazoles - chemistry | Molecular Docking Simulation | Thiazoles - pharmacology | Mutation | Thiophenes - chemistry | Pyrvinium Compounds - pharmacology | Index Medicus
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 04/2019, Volume 188, pp. 59 - 70
Journal Article
Journal Article