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1. Full Text Late Toxicity After Intensity-Modulated Radiation Therapy for Localized Prostate Cancer: An Exploration of Dose–Volume Histogram Parameters to Limit Genitourinary and Gastrointestinal Toxicity
by Pederson, Aaron W., M.D and Fricano, Janine, B.S and Correa, David, B.S and Pelizzari, Charles A., Ph.D and Liauw, Stanley L., M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 82, Issue 1, pp. 235 - 241
Purpose To characterize the late genitourinary (GU) and gastrointestinal (GI) toxicity for prostate cancer patients treated with intensity-modulated radiation... 
Radiology | Hematology, Oncology and Palliative Medicine | DVH guidelines | IMRT | Late toxicity | Prostate cancer | URINARY TOXICITY | PELVIC RADIOTHERAPY | LATE MORBIDITY | RANDOMIZED CONTROLLED-TRIAL | BIOCHEMICAL CONTROL | ONCOLOGY | BLADDER | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ESCALATION | Organs at Risk - radiation effects | Prostatic Neoplasms - radiotherapy | Adenocarcinoma - pathology | Age Factors | Humans | Middle Aged | Urogenital System - radiation effects | Gastrointestinal Tract - radiation effects | Male | Urinary Bladder - radiation effects | Radiotherapy, Intensity-Modulated - adverse effects | Aged, 80 and over | Adult | Prostatic Neoplasms - drug therapy | Adenocarcinoma - radiotherapy | Radiotherapy Dosage | Prostatic Neoplasms - pathology | Radiotherapy, Intensity-Modulated - methods | Rectum - radiation effects | Tumor Burden | Proctitis - etiology | Analysis of Variance | Radiation Injuries - prevention & control | Androgen Antagonists - therapeutic use | Aged | Care and treatment | Radiotherapy | Nuclear radiation | Health aspects | Cancer | Adenocarcinoma | Seminal vesicle | Toxicity | Radiation | Radiation therapy | Multivariate analysis | Morbidity | Androgens | Urinary bladder | Rectum | guidelines | Age | Index Medicus | PROSTATE | PATIENTS | DISEASE INCIDENCE | ELDERLY PEOPLE | RECTUM | RADIATION DOSES | TOXICITY | MULTIVARIATE ANALYSIS | RECOMMENDATIONS | MEN | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | ANDROGENS | HAZARDS
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2. Full Text Dose-dependent transitions in mechanisms of toxicity: case studies
by Slikker, William and Andersen, Melvin E and Bogdanffy, Matthew S and Bus, James S and Cohen, Steven D and Conolly, Rory B and David, Raymond M and Doerrer, Nancy G and Dorman, David C and Gaylor, David W and Hattis, Dale and Rogers, John M and Setzer, R. Woodrow and Swenberg, James A and Wallace, Kendall
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
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3. Full Text Hsp70 reduces α-synuclein aggregation and toxicity
by Klucken, Jochen and Shin, Youngah and Masliah, Eliezer and Hyman, Bradley T and McLean, Pamela J
Journal of Biological Chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 24, pp. 25497 - 25502
Aggregation and cytotoxicity of misfolded alpha-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's... 
ANDROGEN RECEPTOR PROTEIN | OXIDATIVE STRESS | IN-VITRO | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURODEGENERATIVE SYNUCLEINOPATHIES | HEAT-SHOCK | LEWY BODY FORMATION | HUNTINGTONS-DISEASE | BULBAR MUSCULAR-ATROPHY | PARKINSONS-DISEASE | Molecular Weight | Humans | Mice, Transgenic | Synucleins | Protein Folding | Lewy Body Disease - metabolism | Nerve Tissue Proteins - toxicity | Nerve Tissue Proteins - chemistry | Animals | Aged, 80 and over | Cell Line, Tumor | HSP70 Heat-Shock Proteins - physiology | Aged | Mice | Octoxynol - pharmacology | alpha-Synuclein
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4. Full Text Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase II Study—The IPI Trial
by Habl, Gregor, MD and Uhl, Matthias, MD and Katayama, Sonja, MD and Kessel, Kerstin A., PhD and Hatiboglu, Gencay, MD and Hadaschik, Boris, MD and Edler, Lutz, PhD and Tichy, Diana, PhD and Ellerbrock, Malte, PhD and Haberer, Thomas, PhD and Wolf, Maja B., MD and Schlemmer, Heinz-Peter, MD, PhD and Debus, Jürgen, MD, PhD and Herfarth, Klaus, MD
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2016, Volume 95, Issue 1, pp. 435 - 443
Purpose The purpose of this study was to compare safety and feasibility of proton therapy with that of carbon ion therapy in hypofractionated raster-scanned... 
Radiology | Hematology, Oncology and Palliative Medicine | Prostatic Neoplasms - radiotherapy | Heavy Ion Radiotherapy - adverse effects | Prospective Studies | Follow-Up Studies | Heavy Ion Radiotherapy - methods | Humans | Middle Aged | Proton Therapy - adverse effects | Urinary Catheterization - statistics & numerical data | Fatigue - etiology | Male | Feasibility Studies | Dose Hypofractionation | Time Factors | Urinary Retention - therapy | Aged, 80 and over | Prostatic Neoplasms - blood | Safety | Cystitis - etiology | Prostatic Neoplasms - pathology | Rectum - radiation effects | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Disease-Free Survival | Cystitis - pathology | Radiation Injuries - prevention & control | Androgen Antagonists - therapeutic use | Quality of Life | Aged | Proton Therapy - methods | Relative Biological Effectiveness | Protons | Cancer patients | Care and treatment | Oncology, Experimental | Radiation | Research | Prostate cancer | Cancer | Index Medicus | PROSTATE | PATIENTS | NEOPLASMS | RECTUM | GY RANGE 01-10 | ION BEAMS | PROTON BEAMS | TOXICITY | GY RANGE 10-100 | IRRADIATION | RBE | RADIOLOGY AND NUCLEAR MEDICINE | CARBON IONS | RADIOTHERAPY
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5. Full Text Genitourinary Toxicity After High-Dose-Rate (HDR) Brachytherapy Combined With Hypofractionated External Beam Radiotherapy for Localized Prostate Cancer: An Analysis to Determine the Correlation Between Dose–Volume Histogram Parameters in HDR Brachytherapy and Severity of Toxicity
by Ishiyama, Hiromichi, M.D and Kitano, Masashi, M.D and Satoh, Takefumi, M.D and Kotani, Shouko, M.D and Uemae, Mineko, R.T and Matsumoto, Kazumasa, M.D and Okusa, Hiroshi, M.D and Tabata, Ken-ichi, M.D and Baba, Shiro, M.D and Hayakawa, Kazushige, M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2009, Volume 75, Issue 1, pp. 23 - 28
Purpose To evaluate the severity of genitourinary (GU) toxicity in high-dose-rate (HDR) brachytherapy combined with hypofractionated external beam radiotherapy... 
Radiology | Hematology, Oncology and Palliative Medicine | High-dose-rate brachytherapy | Urinary toxicity | 192-Iridium | Prostate cancer | Dose–volume histogram | Dose-volume histogram | BOOST | PHASE-II | RADIATION-THERAPY | TRIAL | ONCOLOGY | RATE IR-192 BRACHYTHERAPY | OPTIMIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ESCALATION | Prostatic Neoplasms - radiotherapy | Age Factors | Humans | Middle Aged | Urogenital System - radiation effects | Male | Urethra - diagnostic imaging | Aged, 80 and over | Adult | Flutamide - therapeutic use | Urethra - radiation effects | Radiotherapy Dosage | Prostatic Neoplasms - pathology | Brachytherapy - methods | Tumor Burden | Radiation Injuries - etiology | Radiography | Regression Analysis | Pilot Projects | Rectum - diagnostic imaging | Iridium Radioisotopes - adverse effects | Radiotherapy - methods | Androgen Antagonists - therapeutic use | Aged | Relative Biological Effectiveness | Brachytherapy - adverse effects | Radiotherapy | Medical colleges | Index Medicus | PROSTATE | URINARY TRACT | NEOPLASMS | IRIDIUM 192 | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | SYMPTOMS | TOXICITY | BRACHYTHERAPY | DOSE RATES | PLANNING
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6. Full Text Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen‐deprivation therapy: a randomised controlled trial
by Cormie, Prue and Galvão, Daniel A and Spry, Nigel and Joseph, David and Chee, Raphael and Taaffe, Dennis R and Chambers, Suzanne K and Newton, Robert U
BJU International, ISSN 1464-4096, 02/2015, Volume 115, Issue 2, pp. 256 - 266
Objective To determine if supervised exercise minimises treatment toxicity in patients with prostate cancer initiating androgen‐deprivation therapy (ADT). This... 
exercise | prostate cancer | aerobic | androgen deprivation | resistance | OLDER-ADULTS | MUSCLE | HELP-SEEKING | SUPPRESSION | CARDIORESPIRATORY FITNESS | RESISTANCE EXERCISE | MEN | UROLOGY & NEPHROLOGY | PHYSICAL-ACTIVITY | AEROBIC EXERCISE | QUALITY-OF-LIFE | Blood Pressure | Body Composition | Exercise Therapy - methods | Bone Density | Antineoplastic Agents, Hormonal - administration & dosage | Humans | Middle Aged | Male | Treatment Outcome | Fatigue - chemically induced | Prostatic Neoplasms - physiopathology | Antineoplastic Agents, Hormonal - adverse effects | Time Factors | Aged, 80 and over | Quality of Life | Stress, Psychological | Physical Fitness | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Muscle Strength | Prostatic Neoplasms - drug therapy | Fatigue - prevention & control | Cancer patients | Care and treatment | Analysis | Clinical trials | Physiological aspects | Bones | Density | Androgens | Physical fitness | Bone density | Exercise | Older people | Men | Index Medicus
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7. Full Text Real-Time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
by Hsieh, Jui-Hua and Huang, Ruili and Lin, Ja-An and Sedykh, Alexander and Zhao, Jinghua and Tice, Raymond R and Paules, Richard S and Xia, Menghang and Auerbach, Scott S
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177902 - e0177902
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U. S. Tox21 screening program, the cytotoxicity of... 
ASSAYS | DEATH | PERTURBATIONS | MECHANISM | CHEMICALS | MULTIDISCIPLINARY SCIENCES | Small Molecule Libraries - classification | Cell Survival - drug effects | Small Molecule Libraries - pharmacology | Oxidative Stress | Humans | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Structure-Activity Relationship | Hep G2 Cells | Signal Transduction - drug effects | Databases, Chemical | HEK293 Cells | Cell Proliferation - drug effects | Environmental Pollutants - toxicity | Histones - metabolism | Toxicity Tests | Cell Membrane - drug effects | Cluster Analysis | Heat shock proteins | Physiological aspects | Research | Multiplexing | Health sciences | Biotechnology | Oxidative stress | Phosphorylation | Profiling | Toxicity | p53 Protein | Cytotoxicity | Activation | Kinases | Heat shock factors | Toxicology | Pathways | Technology | Cell cycle | Clusters | Temporal variations | Stress response | Deoxyribonucleic acid--DNA | Hypothesis testing | Linkages | Environmental health | Big Data | Clustering | Real time | Biological activity | Chemicals | Hypotheses | Cell death | Cell lines | Kinetics | In vitro methods and tests | Viability | Heat shock | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
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8. Full Text Cardiovascular toxicity of illicit anabolic-androgenic steroid use
by Baggish, Aaron L and Weiner, Rory B and Kanayama, Gen and Hudson, James I and Lu, Michael T and Hoffmann, Udo and Pope, Harrison G
Circulation, ISSN 0009-7322, 05/2017, Volume 135, Issue 21, pp. 1991 - 2002
BACKGROUND: Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain... 
Diastolic dysfunction | Cardiology | Cardiomyopathy | Anabolic-androgenic steroids | Atherosclerosis | Men | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | MYOCARDIAL-INFARCTION | TESTOSTERONE | PREVALENCE | TISSUE DOPPLER | cardiology | SOCIETY | WEIGHTLIFTERS | VENTRICULAR HYPERTROPHY | anabolic-androgenic steroids | men | diastolic dysfunction | CONSEQUENCES | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | cardiomyopathy | Coronary Vessels - diagnostic imaging | Diastole | Humans | Middle Aged | Weight Lifting | Male | Systole | Ventricular Dysfunction, Left - chemically induced | Case-Control Studies | Coronary Angiography - methods | Time Factors | Coronary Artery Disease - pathology | Adult | Androgens - adverse effects | Multidetector Computed Tomography | Coronary Vessels - drug effects | Coronary Vessels - pathology | Echocardiography | Cross-Sectional Studies | Risk Assessment | Coronary Artery Disease - chemically induced | Risk Factors | Ventricular Function, Left - drug effects | Stroke Volume - drug effects | Cardiotoxicity | Plaque, Atherosclerotic | Testosterone Congeners - adverse effects | Computed Tomography Angiography | Substance-Related Disorders - complications | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Coronary Artery Disease - diagnostic imaging | Performance-Enhancing Substances - adverse effects | Doping in Sports | Anabolic steroids | CT imaging | Usage | Care and treatment | Cardiovascular diseases | Index Medicus | Abridged Index Medicus
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