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Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Life Sciences, ISSN 0024-3205, 07/2011, Volume 89, Issue 1-2, pp. 57 - 64
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 909 - 924
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2011, Volume 334, Issue 1, pp. 39 - 48
Nuclear hormone receptors (NHRs) are transcription factors that work in concert with co-activators and co-repressors to regulate gene expression. Some examples... 
Molecular evolution | Ciona intestinalis | Oxysterols | Drug modeling | Phylogeny | Bile acids and salts | Cholesterol | CRYSTAL-STRUCTURE | VITAMIN-D-RECEPTOR | XENOBIOTIC RECEPTOR | PREGNANE-X-RECEPTOR | STRUCTURAL DETERMINANTS | CELL BIOLOGY | BILE-ACID METABOLISM | ENDOCRINOLOGY & METABOLISM | LIGAND-BINDING DOMAIN | CIONA-INTESTINALIS | NF-KAPPA-B | CONSTITUTIVE-ANDROSTANE RECEPTOR | Retinoids - metabolism | Receptors, Steroid - metabolism | Humans | Bile Acids and Salts - chemistry | Homeostasis | Vitamin D - chemistry | Orphan Nuclear Receptors - metabolism | Receptors, Calcitriol - genetics | Thyroid Hormones - chemistry | Liver X Receptors | Retinoids - chemistry | Sensitivity and Specificity | Gonadal Steroid Hormones - metabolism | Gene Expression Regulation | Gonadal Steroid Hormones - chemistry | Bile Acids and Salts - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Receptors, Calcitriol - metabolism | Transcription Factors - genetics | Cholesterol - metabolism | Orphan Nuclear Receptors - genetics | Transcription Factors - metabolism | Vertebrates | Animals | Energy Metabolism | Receptors, Steroid - genetics | Thyroid Hormones - metabolism | Vitamin D - metabolism | Invertebrates | Evolution, Molecular | Receptors, Cytoplasmic and Nuclear - metabolism | Cellular | Receptors | Evolutionary | Ligands | Evolution | Hormones | Vitamins | Beta | Index Medicus | oxysterols | cholesterol | phylogeny | drug modeling | molecular evolution
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2008, Volume 107, Issue 6, pp. 1518 - 1528
We have established the expression patterns of the genes encoding ATP‐binding cassette (ABC) transporters and cytochromes P450 (CYPs) at the adult human... 
ATP‐binding cassette transporters | blood–brain barrier | cytochromes P450 | regulation | human | microvessels | Human | Microvessels | ATP-binding cassette transporters | Regulation | Blood-brain barrier | Cytochromes P450 | blood-brain barrier | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | PREGNANE-X-RECEPTOR | NEUROSCIENCES | MICROVESSEL ENDOTHELIUM | P-GLYCOPROTEIN | ARYL-HYDROCARBON RECEPTOR | CONSTITUTIVE ANDROSTANE RECEPTOR | ENDOTHELIAL-CELLS | CENTRAL-NERVOUS-SYSTEM | UP-REGULATION | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Brain Neoplasms - pathology | Cerebral Cortex - pathology | Microvessels - metabolism | Cytochrome P-450 Enzyme System - metabolism | Proteoglycans - metabolism | Antigens - metabolism | Glial Fibrillary Acidic Protein - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Cerebral Cortex - metabolism | Blood-Brain Barrier - metabolism | ATP-Binding Cassette Transporters - genetics | Gene Expression - physiology | ATP-Binding Cassette Transporters - metabolism | Cytochrome P-450 Enzyme System - genetics | Gene Expression Regulation, Neoplastic - physiology | Synaptophysin - metabolism | Gliomas | Neurons | Brain tumors | Cytochrome P-450 | Hydrocarbons | DNA binding proteins | Television broadcasting industry | Gene expression | Neurology | Brain | Biochemistry | Adenosine triphosphatase | Index Medicus
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2011, Volume 8, Issue 4, pp. 1332 - 1341
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette... 
blood-brain barrier | quantitative LC-MS/MS | transporters | drug-metabolizing enzymes | human | PREGNANE-X RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | BARRIER | P-GLYCOPROTEIN | UDP-GLUCURONOSYLTRANSFERASE | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | GLUTATHIONE-S-TRANSFERASE | RAT-BRAIN | PROTEINS | UP-REGULATION | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glutamate Plasma Membrane Transport Proteins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Microvessels - metabolism | Glucose Transporter Type 1 - metabolism | Glutamate Plasma Membrane Transport Proteins - genetics | Excitatory Amino Acid Transporter 1 - genetics | Neoplasm Proteins - metabolism | Brain - metabolism | Brain - blood supply | Tandem Mass Spectrometry | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Chromatography, Liquid | Proteomics - methods | Neoplasm Proteins - genetics | Transcriptome - physiology | Glutathione S-Transferase pi - genetics | Glutathione S-Transferase pi - metabolism | Glutathione Transferase - metabolism | Excitatory Amino Acid Transporter 1 - metabolism | Transcriptome - genetics | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | In Vitro Techniques | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 46, pp. 45062 - 45071
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 6, pp. 3244 - 3261
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2016, Volume 303, pp. 90 - 100
The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal... 
PNPLA3/adiponutrin | Constitutive Androstane Receptor | Lipogenesis | Non-alcoholic fatty liver disease | Liver X Receptor | PREGNANE-X RECEPTOR | FATTY LIVER-DISEASE | CROSS-TALK | GLUCONEOGENIC GENES | TARGET GENES | HUMAN HEPATOCYTES | CAR | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ENERGY-METABOLISM | DRUG-METABOLISM | Phenobarbital - pharmacology | Humans | Male | Hepatocytes - metabolism | RNA, Messenger - metabolism | Liver - drug effects | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Hepatocytes - drug effects | Cell Line | Fatty Liver - metabolism | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Liver X Receptors - metabolism | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Lipase - metabolism | Transcription Factors - genetics | Hep G2 Cells | Mice, Knockout | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Lipogenesis - drug effects | Pyridines - pharmacology | Liver X Receptors - genetics | Lipase - genetics | Liver diseases | Genes | Liver | Genetic research | Physiological aspects | Development and progression | Gene expression | Protein binding | Isoenzymes | Index Medicus | Life Sciences | BENZENE | GLYCEROL | THYROID | 60 APPLIED LIFE SCIENCES | PATHOGENESIS | CYTOCHROMES | METABOLISM | GENES | LIVER CELLS | PHOSPHATES | MICE | METABOLIC DISEASES | ANDROSTANES | LIPIDS | TRANSCRIPTION FACTORS | TRANSCRIPTION | PHENOBARBITAL | POLYPEPTIDES | LIVER | CARBOXYLIC ACIDS | KNOCK-OUT REACTIONS | PHOSPHOTRANSFERASES | RECEPTORS | PHOSPHOENOLPYRUVATE | THYROID HORMONES | CARBOHYDRATES
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 04/2008, Volume 22, Issue 4, pp. 838 - 857
Antagonizing the action of the human nuclear xenobiotic receptor pregnane X receptor (PXR) may have important clinical implications in preventing drug-drug... 
YEAST 2-HYBRID SYSTEM | COMPLEX PROVIDES | TRANSCRIPTIONAL ACTIVATION | SIGNALING PATHWAYS | CRYSTAL-STRUCTURE | ENDOCRINOLOGY & METABOLISM | HEPATIC DRUG-METABOLISM | ST JOHNS WORT | XENOBIOTIC RECEPTOR | CONSTITUTIVE-ANDROSTANE RECEPTOR | ORPHAN NUCLEAR RECEPTOR | Immunohistochemistry | Oxidoreductases, N-Demethylating - genetics | Receptors, Steroid - metabolism | Gene Expression - drug effects | Humans | Phytoestrogens - chemistry | Aryl Hydrocarbon Hydroxylases - genetics | Histone Acetyltransferases - genetics | Receptors, Steroid - antagonists & inhibitors | Ethanol - analogs & derivatives | Cytochrome P-450 CYP3A - genetics | Histone Acetyltransferases - metabolism | Mass Spectrometry | Female | Oxidoreductases, N-Demethylating - metabolism | Phytoestrogens - pharmacology | Cell Line | Coumestrol - metabolism | Ethanol - metabolism | Cells, Cultured | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Coumestrol - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Mice, Knockout | Transcription Factors - metabolism | Microscopy, Confocal | Two-Hybrid System Techniques | Animals | Receptors, Steroid - genetics | Coumestrol - chemistry | Cytochrome P-450 CYP3A - metabolism | Nuclear Receptor Coactivator 1 | Protein Binding | Phytoestrogens - metabolism | Mice | Pregnane X Receptor | Cytochrome P-450 CYP2B6 | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article