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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Prostate cancer resistance to castration occurs because tumours acquire the metabolic capability of converting precursor steroids to 5... 
ANDROGEN RECEPTOR | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | CYP17A1 INHIBITION | MECHANISM | TESTOSTERONE | RATIONALE | MULTIDISCIPLINARY SCIENCES | INCREASED SURVIVAL | CHEMOTHERAPY | EXPOSURE | ENZALUTAMIDE | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 840 - 848
Context: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate.... 
EXCESS | WOMEN | ANDROSTENEDIONE | 11-BETA-HYDROXYANDROSTENEDIONE | ENDOCRINOLOGY & METABOLISM | TANDEM MASS-SPECTROMETRY | 19-CARBON STEROIDS | DEHYDROEPIANDROSTERONE | INCREASED 5-ALPHA-REDUCTASE ACTIVITY | EXPRESSION | ADIPOSE-TISSUE | Hydroxytestosterones - metabolism | Gas Chromatography-Mass Spectrometry | Humans | Testosterone - analogs & derivatives | Androstenedione - metabolism | Case-Control Studies | Young Adult | Androstenedione - analogs & derivatives | Tandem Mass Spectrometry | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Dehydroepiandrosterone - metabolism | Polycystic Ovary Syndrome - metabolism | Obesity - complications | Insulin Resistance | Obesity - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Androstenes - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Body mass index | Demographics | Polycystic ovary syndrome | Spectroscopy | Excretion | Markers | Mass spectroscopy | Liquid chromatography | Metabolism | Insulin | Patients | Chromatography | Testosterone | Gas chromatography | Androgens | Dehydroepiandrosterone | Body mass | Body size | Insulin resistance | Scientific imaging | Androstenedione | Oxygenation | Mass spectrometry | Steroid hormones | Steroids | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 547 - 551
Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral... 
ACTIVATION | CYP17A1 INHIBITION | RAT | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | BIOLOGY | MEN | RESISTANCE | STEROID 5-ALPHA-REDUCTASE | DIHYDROTESTOSTERONE | DEHYDROGENASE | Prostatic Neoplasms - metabolism | Dutasteride - therapeutic use | Humans | Receptors, Androgen - metabolism | Androgens - biosynthesis | Male | Androstenes - pharmacology | Abiraterone Acetate - administration & dosage | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Oxidation-Reduction - drug effects | Prostatic Neoplasms - blood | Androstenes - blood | Prostatic Neoplasms - drug therapy | Administration, Oral | Prostatic Neoplasms, Castration-Resistant - blood | Androgen Antagonists - pharmacology | 5-alpha Reductase Inhibitors - therapeutic use | Abiraterone Acetate - therapeutic use | Dutasteride - pharmacology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Androstenes - administration & dosage | Prostatic Neoplasms, Castration-Resistant - metabolism | Disease Progression | Xenograft Model Antitumor Assays | Animals | Abiraterone Acetate - blood | Abiraterone Acetate - metabolism | 5-alpha Reductase Inhibitors - pharmacology | Androgen Antagonists - therapeutic use | Androstenes - metabolism | Cell Line, Tumor | Mice | Physiological aspects | Prostate cancer | Care and treatment | Enzymes | Androgens | Metabolites | Oxidation | Metabolism | Gene expression | Steroids | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2701 - 2710
Context: Patients with 21-hydroxylase deficiency (21OHD) have long-term complications, resulting from poor disease control and/or glucocorticoid overtreatment.... 
ADRENOGENITAL SYNDROME | STIMULATION | FINAL HEIGHT | ADULT MALES | TISSUE | ENDOCRINOLOGY & METABOLISM | PATIENT | PREVALENCE | LONGITUDINAL ANALYSIS | 19-CARBON STEROIDS | HYPERPLASIA | Adrenal Glands - pathology | Hydroxytestosterones - metabolism | 17-alpha-Hydroxypregnenolone - analogs & derivatives | Adrenal Rest Tumor - metabolism | Humans | Middle Aged | Child, Preschool | Male | Hirsutism - metabolism | Testosterone - analogs & derivatives | Age Determination by Skeleton | Androstenedione - metabolism | Pregnenolone - metabolism | Young Adult | Androstenedione - analogs & derivatives | Menstruation Disturbances - metabolism | Testosterone - metabolism | Adult | Female | Child | 17-alpha-Hydroxypregnenolone - metabolism | Cross-Sectional Studies | Adrenal Hyperplasia, Congenital - metabolism | Testicular Neoplasms - metabolism | Organ Size | Cortodoxone - metabolism | Adolescent | Androstenes - metabolism | Aged | Androgens - metabolism | Drugs | Correlation | Glucocorticoids | Disorders | Bone tumors | Hormones | Males | Sulfates | Pregnenolone | Spectrometry | Bioindicators | Children | Pituitary hormones | Menstruation | Complications | Hydroxylase | Hirsutism | Disease control | Patients | Testosterone | Androgens | Pregnenolone sulfate | Pituitary | Biomarkers | Adults | Sulfate | Females | Testes | Oxygenation | Steroid hormones | Tumors | Steroids | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2009, Volume 184, Issue 6, pp. 863 - 879
Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular functions such as proliferation, differentiation, and... 
COS cells | T lymphocytes | Endocytosis | Receptors | Antibodies | Lysosomes | Cell membranes | Physiological regulation | Cells | Endosomes | ENDOCYTIC COMPARTMENT | LOCALIZATION | ACTIVATION | H-RAS | K-RAS | LOW-DENSITY-LIPOPROTEIN | RECEPTOR | GOLGI | PLASMA-MEMBRANE | LIVING CELLS | CELL BIOLOGY | ras Proteins - genetics | Phosphorylation | Humans | Cercopithecus aethiops | ras Proteins - metabolism | Androstenes - pharmacology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Lysosomes - metabolism | Transfection | Time Factors | Protein Kinase C - metabolism | Endosomes - drug effects | Macrolides - pharmacology | Cell Membrane - metabolism | Vero Cells | Cell Membrane - drug effects | Recombinant Proteins - metabolism | Calmodulin - metabolism | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Epidermal Growth Factor - metabolism | Clathrin - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Protein Transport | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | HeLa Cells | Mutation | GRB2 Adaptor Protein - metabolism | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Research | Properties | Protein kinases | Cellular control mechanisms | Proteins | Cell division | Biochemistry | Kinases | Apoptosis | Index Medicus | Cellular signal transduction | Ras proteins | Proteïnes ras | Transducció de senyal cel·lular
Journal Article
Journal of cell science, ISSN 0021-9533, 2013, Volume 126, Issue Part 17, pp. 3961 - 3971
N-myc downstream-regulated gene 1 (NDRG1) mutations cause Charcot-Marie-Tooth disease type 4D (CMT4D). However, the cellular function of NDRG1 and how it... 
Endocytosis | IDOL | Multivesicular body | NDRG1 | Cholesterol | CLATHRIN-MEDIATED ENDOCYTOSIS | DIFFERENTIAL EXPRESSION | C DISEASE | MARIE-TOOTH NEUROPATHY | SENSORY NEUROPATHY | CELL BIOLOGY | HEREDITARY MOTOR | DEMYELINATING NEUROPATHY | ESCRT MACHINERY | CHOLESTEROL HOMEOSTASIS | DENSITY-LIPOPROTEIN RECEPTOR | Refsum Disease - metabolism | Endosomal Sorting Complexes Required for Transport - biosynthesis | Vesicular Transport Proteins - metabolism | Humans | Refsum Disease - genetics | Androstenes - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | GTP-Binding Proteins - genetics | Endosomes - metabolism | Charcot-Marie-Tooth Disease - genetics | Ubiquitination | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | HEK293 Cells | Nerve Tissue Proteins - biosynthesis | Cell Cycle Proteins - genetics | Cell Differentiation | Cell Membrane - metabolism | Endocytosis - genetics | Lipoproteins, LDL - metabolism | Charcot-Marie-Tooth Disease - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Down-Regulation | Vesicular Transport Proteins - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Receptors, LDL - metabolism | Oligodendrocyte Transcription Factor 2 | Protein Transport - genetics | Nerve Tissue Proteins - metabolism | Animals | Cell Line, Tumor | Mice | RNA, Small Interfering | GTP-Binding Proteins - metabolism | Index Medicus
Journal Article
Journal Article
Glia, ISSN 0894-1491, 11/2017, Volume 65, Issue 11, pp. 1728 - 1743
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 47, pp. 32952 - 32964
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 05/2017, Volume 139, pp. 9 - 17
Journal Article
Science of the Total Environment, ISSN 0048-9697, 03/2013, Volume 447, pp. 152 - 159
Four different polycyclic aromatic hydrocarbons (naphthalene, phenanthrene, pyrene, chrysene) and their hydroxylated metabolites (1-hydroxynaphthalene,... 
P450 aromatase | Carp | 11β-HSD2 | C17,20-Lyase | CYP11β | PAH metabolites | CLARIAS-GARIEPINUS | FLOUNDER PLATICHTHYS-FLESUS | RAINBOW-TROUT | 11 beta-HSD2 | POLYCYCLIC AROMATIC-HYDROCARBONS | SEX-DIFFERENTIATION | AFRICAN CATFISH | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | ENVIRONMENTAL SCIENCES | IN-VITRO | REPRODUCTIVE STEROIDS | CYP11 beta | TROUT ONCORHYNCHUS-MYKISS | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Testis - metabolism | Polycyclic Aromatic Hydrocarbons - toxicity | Aromatase - metabolism | Male | Testis - drug effects | Chrysenes - toxicity | Female | Ovary - drug effects | Estrogens - metabolism | Pyrenes - toxicity | Phenanthrenes - metabolism | Ovary - metabolism | Hydroxylation | Pyrenes - metabolism | Carps | Mitochondria - metabolism | Mitochondria - drug effects | Chrysenes - metabolism | Animals | Polycyclic Aromatic Hydrocarbons - metabolism | Water Pollutants, Chemical - toxicity | Polycyclic Aromatic Hydrocarbons - chemistry | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Androstenes - metabolism | Phenanthrenes - toxicity | Steroid 17-alpha-Hydroxylase - metabolism | Androgens - metabolism | Subcellular Fractions | Toxicity Tests | Androgens | Polycyclic aromatic hydrocarbons | Metabolites | Estrogen | Cytochrome P-450 | Index Medicus | Inhibitors | Synthesis | Estrogens | Testes | Gonads
Journal Article
Cellular Microbiology, ISSN 1462-5814, 04/2012, Volume 14, Issue 4, pp. 560 - 576
Intracellular cholesterol amounts, distribution and traffic are tightly regulated to maintain the healthy eukaryotic cell function. However, how intracellular... 
AGENT | NIEMANN-PICK C1 | HUMAN GRANULOCYTIC EHRLICHIOSIS | CELLS | RECYCLING ENDOSOMES | PROTEIN | GOLGI NETWORK | MEMBRANE | TRAFFICKING | MICROBIOLOGY | INFECTION | CELL BIOLOGY | Membrane Glycoproteins - metabolism | Humans | Glycoproteins - metabolism | R-SNARE Proteins - metabolism | Androstenes - pharmacology | Anaplasma phagocytophilum - drug effects | Syntaxin 16 - genetics | Cell Membrane - metabolism | Membrane Proteins - metabolism | Inclusion Bodies - metabolism | Syntaxin 16 - metabolism | Anaplasma phagocytophilum - metabolism | Oxytetracycline - pharmacology | Ehrlichiosis - microbiology | Glycoproteins - genetics | Lysosome-Associated Membrane Glycoproteins - metabolism | Membrane Proteins - genetics | R-SNARE Proteins - genetics | Bacterial Proteins - genetics | Gene Expression Regulation | Cholesterol - metabolism | Ehrlichiosis - metabolism | Membrane Glycoproteins - genetics | Protein Transport | Host-Pathogen Interactions | Carrier Proteins - genetics | Carrier Proteins - metabolism | Transport Vesicles - metabolism | HL-60 Cells | Lysosome-Associated Membrane Glycoproteins - genetics | Bacterial Proteins - metabolism | Anaplasma phagocytophilum - pathogenicity | Lysosomal-Associated Membrane Protein 2 | Low density lipoproteins | Cells | Cholesterol | Pathogens | Anaplasmosis | Homeostasis | siRNA | Membrane proteins | Infection | Syntaxin | Lipoproteins | Vesicles | Npc1 protein | N-Ethylmaleimide-sensitive protein | Protein transport | Index Medicus | Anaplasma phagocytophilum | Inclusion | syntaxin 16 | NPC1 | LAMP-1 | LAMP-2 | VAMP4
Journal Article