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Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Polymerase | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
CURRENT MEDICINAL CHEMISTRY, ISSN 0929-8673, 2017, Volume 24, Issue 15, pp. 1488 - 1503
DNA-damaging drugs in cancer present two main problems: therapeutic resistance and side effects and both can associate with DNA repair, which can be targeted in cancer therapy. Bleomycin (BLM... 
bleomycin | mitomycin C | CHEMISTRY, MEDICINAL | TOPOISOMERASE-II | DNA quadruplex | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | synthetic lethality | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | DNA repair | FANCONI-ANEMIA | TUMOR-INITIATING CELLS | CANCER STEM-CELLS | DNA-damaging drugs | PHARMACOLOGY & PHARMACY | DNA topoisomerase 1 and 2 inhibitors | HUMAN RECQ HELICASES | HIGH-RISK NEUROBLASTOMA | RNA G-QUADRUPLEX | DNA Damage - drug effects | Antibiotics, Antineoplastic - toxicity | G-Quadruplexes - drug effects | Phosphoric Diester Hydrolases - metabolism | Topoisomerase Inhibitors - toxicity | Humans | DNA Topoisomerases - metabolism | DNA Topoisomerases - chemistry | Neoplasms - drug therapy | Phosphoric Diester Hydrolases - chemistry | Topoisomerase Inhibitors - therapeutic use | Antibiotics, Antineoplastic - therapeutic use | Bleomycin - therapeutic use | DNA Repair | Topoisomerase Inhibitors - chemistry | Neoplasms - pathology | Bleomycin - toxicity | Cell proliferation | Drugs | Therapy | Protein kinase C | Toxicity | Stabilization | DNA damage | Poly(ADP-ribose) | Xeroderma pigmentosum | Lethality | Kinases | Guanine | Proteins | Antitumor agents | Bleomycin | Pathways | Ribose | Mitomycin C | Catalysis | Repair | Telomerase | Deoxyribonucleic acid--DNA | Adducts | Phosphodiesterase | Mitomycin | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Nucleotide excision repair | Crosslinking | Substrates | Polymerase | Telomeres | Poly(ADP-ribose) Polymerase 1 | Side effects | DNA-dependent protein kinase | DNA adducts | Cancer
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 2005, Volume 118, Issue 10, pp. 1154 - 1159
Approximately 15% of people aged more than 60 years old have a cobalamin (vitamin B12) deficiency, mainly in relation with food-cobalamin malabsorption (FCM).... 
Drugs | Cobalamin deficiency | Atrophic gastritis | Oral cobalamin treatment | Food-cobalamin malabsorption | Elderly patients | elderly patients | HOMOCYSTEINE | food-cobalamin malabsorption | drugs | atrophic gastritis | METHYLMALONIC ACID | PERNICIOUS-ANEMIA | VITAMIN-B12 DEFICIENCY | DIAGNOSING COBALAMIN | MEDICINE, GENERAL & INTERNAL | THERAPY | oral cobalamin treatment | MEGALOBLASTIC-ANEMIA | cobalamin deficiency | FOLATE | Malabsorption Syndromes - diagnosis | Follow-Up Studies | Vitamin B 12 Deficiency - blood | Humans | Hematologic Diseases - drug therapy | Erythrocyte Indices | Male | Polyneuropathies - drug therapy | Paresthesia - etiology | Vitamin B 12 - therapeutic use | Jaundice - drug therapy | Asthenia - drug therapy | Malabsorption Syndromes - blood | Reflex, Abnormal | Cognition Disorders - etiology | Vitamin B 12 Deficiency - complications | Aged, 80 and over | Female | Gastritis, Atrophic - etiology | Retrospective Studies | Malabsorption Syndromes - drug therapy | Gastritis, Atrophic - drug therapy | Confusion - drug therapy | Homocysteine - blood | Edema - drug therapy | Vitamin B 12 - blood | Cognition Disorders - drug therapy | Vitamin B 12 Deficiency - drug therapy | Edema - etiology | Paresthesia - drug therapy | Confusion - etiology | Polyneuropathies - etiology | Asthenia - etiology | Hematologic Diseases - etiology | Aged | Hemoglobins - analysis | Jaundice - etiology | Cohort Studies | Medical examination | Malabsorption syndromes | Aged patients | Dosage and administration | Research | Drug therapy | Vitamin B12 | Risk factors | Diseases
Journal Article
Pediatrics, ISSN 0031-4005, 02/2013, Volume 131, Issue 2, pp. e629 - e634
... abnormalities in which hydroxocobalamin and folate therapy provided partial immune reconstitution... 
Cobalamin | Megaloblast | Hemolytic uremic syndrome | Folate | Immunodeficiency | folate | DEFECTS | cobalamin | GENE | megaloblast | TRANSCOBALAMIN-II DEFICIENCY | ABNORMALITIES | PEDIATRICS | immunodeficiency | PATIENT | hemolytic uremic syndrome | Peripheral Nervous System Diseases - diagnosis | Leukopenia - diagnosis | Lipid Metabolism, Inborn Errors - genetics | Pneumonia, Pneumocystis - diagnosis | Humans | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Vitamin B 12 - therapeutic use | DNA Mutational Analysis | Sulfadoxine - therapeutic use | Cardiomyopathies - diagnosis | Infant, Newborn | Cardiomyopathies - drug therapy | Mitochondrial Myopathies | Retinitis Pigmentosa - drug therapy | Trimethoprim - therapeutic use | Combined Modality Therapy | Bone Marrow Examination | Sequence Analysis, DNA | Retinitis Pigmentosa - diagnosis | Severe Combined Immunodeficiency - genetics | Pneumonia, Pneumocystis - genetics | Immunization, Passive | Leukopenia - drug therapy | Genetic Carrier Screening | Peripheral Nervous System Diseases - drug therapy | Mitochondrial Trifunctional Protein - deficiency | Anemia, Megaloblastic - genetics | Minor Histocompatibility Antigens | Lipid Metabolism, Inborn Errors - drug therapy | Leukopenia - genetics | Infant | Rhabdomyolysis | Cardiomyopathies - genetics | Anemia, Megaloblastic - diagnosis | Female | Drug Therapy, Combination | Peripheral Nervous System Diseases - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Hydroxocobalamin - therapeutic use | Pneumonia, Pneumocystis - drug therapy | Severe Combined Immunodeficiency - diagnosis | Lipid Metabolism, Inborn Errors - diagnosis | Severe Combined Immunodeficiency - drug therapy | Retinitis Pigmentosa - genetics | Opportunistic Infections - genetics | Opportunistic Infections - diagnosis | Exome - genetics | Opportunistic Infections - drug therapy | Anemia, Megaloblastic - drug therapy | 3-Hydroxyacyl CoA Dehydrogenases - deficiency | Drug Combinations | Nervous System Diseases | Care and treatment | Gene mutations | Research | Nucleotide sequencing | Diagnosis | Vitamin B12 | Hemolytic-uremic syndrome | DNA sequencing | Pediatrics | Immunology | Vitamin B | Genetics | Mutation | Drug therapy | Metabolism
Journal Article
Intensive care medicine, ISSN 1432-1238, 2017, Volume 43, Issue 3, pp. 304 - 377
Journal Article
Journal of Crohn's and colitis, ISSN 1876-4479, 2013, Volume 7, Issue 1, pp. 1 - 33
Journal Article