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The Lancet (British edition), ISSN 0140-6736, 2010, Volume 376, Issue 9757, pp. 2018 - 2031
Summary Sickle-cell disease is one of the most common severe monogenic disorders in the world... 
Internal Medicine | FETAL-HEMOGLOBIN LEVELS | MEDICINE, GENERAL & INTERNAL | HOSPITAL ADMISSIONS | RISK-FACTORS | PULMONARY-HYPERTENSION | ACUTE CHEST SYNDROME | HYDROXYUREA THERAPY | NITRIC-OXIDE | ADHESION MOLECULES | ACUTE VASOOCCLUSIVE CRISIS | PLASMODIUM-FALCIPARUM MALARIA | Haplotypes | Antisickling Agents - therapeutic use | Acute Chest Syndrome - etiology | Acute Chest Syndrome - therapy | Humans | Pain Management | Hypertension, Pulmonary - therapy | Blood Transfusion | Anemia, Sickle Cell - epidemiology | Erythrocytes - pathology | Pain - etiology | Anemia, Sickle Cell - classification | Hemolysis | Severity of Illness Index | Gene Transfer Techniques | Iron Chelating Agents - therapeutic use | Disease Susceptibility | Anemia, Sickle Cell - complications | Africa | Hematopoietic Stem Cell Transplantation | Polymerization | Nervous System Diseases - therapy | Anemia, Sickle Cell - therapy | Heart Diseases - etiology | Mass Screening | Heart Diseases - therapy | Kidney Diseases - therapy | Nervous System Diseases - etiology | Hydroxyurea - therapeutic use | Anemia, Sickle Cell - blood | Anemia, Sickle Cell - diagnosis | Kidney Diseases - etiology | Hypertension, Pulmonary - etiology | Hematopoietic Stem Cells | Care and treatment | Sickle cell anemia | Hemoglobin | Development and progression | Diagnosis | Health aspects | Risk factors | Disease | Rodents | Nitric oxide | Mutation | Gene therapy | Epidemiology | Federal funding
Journal Article
TheScientificWorld, ISSN 1537-744X, 8/2012, Volume 2012, pp. 949535 - 55
... of the β globin polypeptide chain. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing multiple phenotypic expressions that constitute the various complications of sickle cell... 
ACTIVITY LIMITATIONS INTERVIEW | HEMOLYTIC TRANSFUSION REACTION | BONE-MINERAL DENSITY | ACUTE HEPATIC SEQUESTRATION | ACUTE CHEST SYNDROME | ACUTE SPLENIC SEQUESTRATION | OPTICAL COHERENCE TOMOGRAPHY | MULTIDISCIPLINARY SCIENCES | RANDOMIZED CLINICAL-TRIAL | PLACENTA GROWTH-FACTOR | ORBITAL COMPRESSION SYNDROME | Hydroxyurea - pharmacology | Humans | Gastrointestinal Diseases - etiology | Retinal Diseases - therapy | Hypertension, Pulmonary - physiopathology | Sulfones - pharmacology | Muscular Diseases - etiology | Sildenafil Citrate | Pain - drug therapy | Retinal Diseases - etiology | Gastrointestinal Diseases - drug therapy | Muscular Diseases - drug therapy | Pain - etiology | Hypertension, Pulmonary - drug therapy | Blood Transfusion - methods | Anemia, Sickle Cell - complications | Purines - pharmacology | Nervous System Diseases - drug therapy | Gastrointestinal Diseases - therapy | Treatment Outcome | Clinical Trials as Topic | Piperazines - pharmacology | Nervous System Diseases - therapy | Phenotype | Pain - physiopathology | Nervous System Diseases - etiology | Disease Management | Retinal Diseases - drug therapy | Hypertension, Pulmonary - etiology | Muscular Diseases - therapy | Anemia, Sickle Cell - genetics | Blood transfusions | Glutamic acid | Stroke | Medical imaging | Sickle cell anemia | Nuclear magnetic resonance--NMR | Hematology | Comorbidity | Anemia | Complications | Mortality | Iron | Disease control | Seminars | Valine | Point mutation | Hemoglobin | Adults | Mutation | Sickle cell disease
Journal Article