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Anesthesiology, ISSN 0003-3022, 02/2016, Volume 124, Issue 2, pp. 428 - 442
Journal Article
Biophysical Journal, ISSN 0006-3495, 09/2010, Volume 99, Issue 6, pp. 1801 - 1809
Cys-loop receptors are molecular targets of general anesthetics, but the knowledge of anesthetic binding to these proteins remains limited. Here we investigate... 
TRYPTOPHAN FLUORESCENCE | MOLECULAR-DYNAMICS | GABA(A) RECEPTOR | BIOPHYSICS | STRUCTURAL BASIS | SERUM-ALBUMIN | AMINO-ACIDS | 4-ALPHA-HELIX BUNDLE | HIGH-RESOLUTION | NICOTINIC ACETYLCHOLINE-RECEPTOR | AGONIST BINDING | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Substrate Specificity | Anesthetics - pharmacology | Protein Subunits - metabolism | Extracellular Space - metabolism | Thiopental - chemistry | Thiopental - metabolism | Volatilization | Anesthetics - metabolism | Cell Membrane - metabolism | Ligand-Gated Ion Channels - metabolism | Binding Sites | Halothane - pharmacology | Protein Structure, Tertiary | Bacterial Proteins - antagonists & inhibitors | Ligand-Gated Ion Channels - antagonists & inhibitors | Reproducibility of Results | Anesthetics - chemistry | Ligand-Gated Ion Channels - chemistry | Spectrometry, Fluorescence | Halothane - chemistry | Protein Structure, Quaternary - drug effects | Molecular Dynamics Simulation | Thiopental - pharmacology | Cyanobacteria - cytology | Halothane - metabolism | Protein Binding | Bacterial Proteins - metabolism | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Protein Multimerization - drug effects | Proteins | Medical colleges | Analysis | Halothane | Crystals | Fluorescence | Tryptophan | Chemical properties | Structure | Protein binding | Binding | Computer simulation | Molecular dynamics | Bacteria | Anesthetics | Channels | Quenching | Membrane
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 03/2017, Volume 21, Issue 3, pp. 579 - 587
The local anaesthetics (LAs) are widely used for peripheral nerve blocks, epidural anaesthesia, spinal anaesthesia and pain management. However, exposure to... 
tuberin/mTOR/p70S6K signalling | local anaesthetics | neurotoxicity | autophagy | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROTEIN | INJURY | PERIPHERAL-NERVE BLOCKS | CELL-DEATH | CELL BIOLOGY | HEART | IN-VITRO | INHIBITION | PATHWAY | COMPLICATIONS | Tumor Suppressor Proteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagy - physiology | Apoptosis Regulatory Proteins - metabolism | Anesthetics, Local - adverse effects | Up-Regulation - physiology | Cell Line, Tumor | Signal Transduction - physiology | Neuroblastoma - metabolism | Anesthetics, Local - metabolism | Beclin-1 - metabolism | Cell Survival - physiology | RNA, Small Interfering - metabolism | Proteins | Proteolysis | Analysis | Anesthesia | Neurotoxicity | Autophagy | Rodents | TOR protein | Phosphorylation | Peripheral nerves | Fluorescence | Immunoblotting | Lipids | Activation | Ropivacaine | Neuroblastoma | Kinases | Dosage | Damage prevention | Degradation | Alterations | Bupivacaine | Pain | Transfection | Inhibition | Growth factors | Tetracaine | Fluctuations | Flux | siRNA | Gene expression | Anesthetics | Organelles | Studies | Signaling | p62 Protein | Tuberin | Morphology | Lidocaine | Viability | Phagocytosis | Apoptosis | Index Medicus | p70S6K signalling | mTOR | Original | tuberin
Journal Article
Anesthesia and Analgesia, ISSN 0003-2999, 2011, Volume 113, Issue 4, pp. 941 - 946
Journal Article
Pharmacogenomics, ISSN 1462-2416, 02/2011, Volume 12, Issue 2, pp. 215 - 233
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e35324
Background: Propofol exerts protective effects on neuronal cells, in part through the inhibition of programmed cell death. Autophagic cell death is a type of... 
OXIDATIVE STRESS | BECLIN 1 | INHIBITION | GLUTAMATE RELEASE | HYPOXIA-ISCHEMIA | PROTECTION | MULTIDISCIPLINARY SCIENCES | NEURONAL INJURY | APOPTOTIC MECHANISMS | FOREBRAIN ISCHEMIA | CULTURES | Beclin-1 | Cell Survival - drug effects | Pyramidal Cells - metabolism | Microtubule-Associated Proteins - metabolism | Reperfusion Injury | Class III Phosphatidylinositol 3-Kinases - metabolism | Rats | Male | PC12 Cells | Rats, Sprague-Dawley | Autophagy - drug effects | Cerebral Cortex - metabolism | Oxygen - metabolism | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Glucose - metabolism | Pyramidal Cells - drug effects | Cerebral Cortex - drug effects | Propofol - administration & dosage | Prevention | Proteins | Ischemia | Neurons | Phenols | Biochemistry | Propofol | Glucose | Dextrose | Apoptosis | Occlusion | Neuroprotection | Spinal cord | Dehydrogenases | Bcl-2 protein | Leukemia | Homeostasis | Phagosomes | Nervous system | Autophagy | Mitochondria | Reperfusion | Cerebral blood flow | Rodents | Microtubule-associated protein 1 | Anesthesia | Inhibition | Quantitative analysis | Deprivation | Oxygen | Cell survival | Mortality | Cultures | Electron microscopy | Survival | 1-Phosphatidylinositol 3-kinase | Transmission electron microscopy | Cell death | Pyramidal cells | Morphology | Pheochromocytoma cells | Hypoxia | Anesthesiology | Phagocytosis | Hippocampus
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 03/2012, Volume 228, Issue 2, pp. 319 - 327
► The volatile anesthetic isoflurane impairs cognitive function of 18-month old rats. ► Lidocaine, a local anesthetic, attenuates the above isoflurane effects.... 
Aged rats | β-Amyloid peptide | Cognitive functions | Isoflurane | NITROUS OXIDE ANESTHESIA | ALZHEIMERS-DISEASE | AMYLOID-BETA-PROTEIN | GENERAL-ANESTHESIA | NEUROSCIENCES | beta-Amyloid peptide | NEUROCOGNITIVE FUNCTION | MOUSE MODEL | IN-VIVO | A-BETA | BEHAVIORAL SCIENCES | DYSFUNCTION | Tumor Necrosis Factor-alpha - metabolism | Cognition Disorders - chemically induced | Rats, Inbred F344 | Aging - drug effects | Fear - drug effects | Isoflurane - adverse effects | Lidocaine - therapeutic use | Male | Phosphopyruvate Hydratase - metabolism | Anesthetics, Inhalation - adverse effects | Synapses - pathology | Brain - metabolism | Drug Interactions | Synapses - metabolism | Time Factors | Interleukin-1beta - metabolism | Amyloid beta-Peptides - metabolism | Brain - ultrastructure | Anesthetics, Local - therapeutic use | Synaptophysin - metabolism | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Enzyme-Linked Immunosorbent Assay | Conditioning (Psychology) - drug effects | Rats | Memory, Short-Term - drug effects | Synapses - ultrastructure | Cognition Disorders - drug therapy | Maze Learning - drug effects | Brain - drug effects | Gene Expression Regulation - drug effects | Animals | Brain - pathology | Peptides | Anesthesia | Computer-aided design | Lidocaine | Alzheimer's disease | Enzyme-linked immunosorbent assay | aged rats | β-amyloid peptide | isoflurane | cognitive functions
Journal Article
Traffic, ISSN 1398-9219, 04/2011, Volume 12, Issue 4, pp. 372 - 385
Microfluidic devices have been developed for imaging behavior and various cellular processes in Caenorhabditis elegans, but not subcellular processes requiring... 
anesthetic | C. elegans | synaptic growth | L1 early larvae | microfluidic device | pre‐synaptic vesicle transport | dendritic transport | mitochondrial transport | Q neuroblast division | Drosophila larvae | intraflagellar transport | Intraflagellar transport | Anesthetic | Synaptic growth | Pre-synaptic vesicle transport | Dendritic transport | Mitochondrial transport | Microfluidic device | ON-CHIP | AXONAL-TRANSPORT | NEMATODE CAENORHABDITIS-ELEGANS | CILIA | MOTOR AXONS | DROSOPHILA | CELL BIOLOGY | LEVAMISOLE RESISTANCE | C-ELEGANS | pre-synaptic vesicle transport | elegans | VESICLE | Microfluidic Analytical Techniques - methods | Dendrites - metabolism | Green Fluorescent Proteins - metabolism | Synaptic Vesicles - metabolism | Animals, Genetically Modified | Drosophila | Axons - metabolism | Anesthetics - pharmacology | Cytoplasmic Streaming | Mitochondria - metabolism | Subcellular Fractions - metabolism | Caenorhabditis elegans | Animals | Biological Transport | Time-Lapse Imaging - methods | Neurons - metabolism | Neurons - drug effects | Dissection | Organelles - metabolism | Synaptic Membranes - metabolism | Fluorescence | Anesthetics | Neurons | Mitochondria | Developmental stages | Synaptogenesis | Neuroblasts | Green fluorescent protein | Synaptic vesicles | spatial discrimination | Axonal transport | Microfluidics
Journal Article