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Cell Cycle, ISSN 1538-4101, 03/2013, Volume 12, Issue 5, pp. 783 - 802
Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on... 
aneuploidy proximate carcinogen | clonal and flexible cancer karyotypes | Muller's ratchet | selection for cancer-specific autonomy | karyotypes of immortal clones of telomerase-deficient mice | sub-speciation via karyotypic drift | low probability of speciation | karyotypic linkage of immortality and tumorigenicity | long preneoplastic latency | growth advantages of aneuploidy | Karyotypic linkage of immortality and tumorigenicity | Low probability of speciation | Growth advantages of aneuploidy | Selection for cancer-specific autonomy | Sub-speciation via karyotypic drift | Aneuploidy proximate carcinogen | Karyotypes of immortal clones of telomerase-deficient mice | Clonal and flexible cancer karyotypes | Long preneoplastic latency | LIFE-SPAN | LARGE T-ANTIGEN | NEOPLASTIC TRANSFORMATION | CELL BIOLOGY | IN-VITRO | HUMAN FIBROBLASTS | CHROMOSOME REASSORTMENTS | MULTIDRUG-RESISTANCE | HUMAN TUMOR-CELLS | MAMMARY EPITHELIAL-CELLS | TELOMERE LENGTH | Humans | Aneuploidy | Drug Resistance, Neoplasm | Chromosomes, Human - metabolism | Telomerase - deficiency | Tetraploidy | Diploidy | Phenotype | Animals | Transfection | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Karyotyping | Aged, 80 and over | Cell Line, Tumor | Female | Telomerase - metabolism | Clone Cells | Mice | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Simian virus 40 - metabolism | Cell Line, Transformed | Report | Muller’s ratchet
Journal Article
Nature communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, p. 12160
Journal Article
Gut Microbes, ISSN 1949-0976, 11/2015, Volume 6, Issue 6, pp. 370 - 376
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Journal Article
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