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Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7291, pp. 1052 - 1057
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to... 
B-CELLS | ANTI-P185HER2 ANTIBODY | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | REGULATORY REGION | MALIGNANT-MELANOMA | MUTATIONS | LEUKEMIA | GAMMA-SECRETASE | CANCER-THERAPY | INHIBITS TUMOR-GROWTH | Angiogenesis Inhibitors - immunology | Neoplasms - metabolism | NIH 3T3 Cells | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Receptor, Notch2 - antagonists & inhibitors | Receptors, Notch - metabolism | Humans | Goblet Cells - drug effects | Receptors, Notch - genetics | Peptide Library | Receptors, Notch - antagonists & inhibitors | Antibody Specificity - immunology | Angiogenesis Inhibitors - therapeutic use | Antibodies - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Antibodies - therapeutic use | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Angiogenesis Inhibitors - pharmacology | Receptor, Notch1 - immunology | Neoplasms - blood supply | Receptor, Notch2 - immunology | Antibodies - adverse effects | Neoplasms - drug therapy | Antibodies - pharmacology | Animals | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Goblet Cells - pathology | Receptor, Notch1 - antagonists & inhibitors | Neoplasms - pathology | Receptors, Notch - immunology | Viral antibodies | Proteases | Proteolysis | Physiological aspects | Antibodies | Research | Properties | Membrane proteins | Cell growth | Cell cycle | Cancer | Crystal structure | Apoptosis | Receptors | Inhibitors | Toxicity | Notches | Mathematical models | Inhibition | Signalling | Diseases | Index Medicus
Journal Article
Angiogenesis, ISSN 0969-6970, 6/2012, Volume 15, Issue 2, pp. 171 - 185
Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis and vascular leak associated with cancers and various eye diseases.... 
Biomedicine | Age-related macular degeneration | Cancer Research | Oncology | Affinity | Ophthalmology | VEGF receptor | Cardiology | Aflibercept | Placental growth factor | Biomedicine general | Cell Biology | ANGIOGENESIS | EFFICACY | MACULAR DEGENERATION | PHASE-II | ANTIBODY | FACTOR THERAPY | EYE | IN-VITRO | PEGAPTANIB | RETINAL DISEASES | PERIPHERAL VASCULAR DISEASE | Angiogenesis Inhibitors - immunology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor B - antagonists & inhibitors | Recombinant Fusion Proteins - pharmacology | Endothelial Cells - metabolism | Humans | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor B - immunology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - immunology | Enzyme Activation - drug effects | Bevacizumab | Endothelial Cells - immunology | Vascular Endothelial Growth Factor B - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | HEK293 Cells | Ranibizumab | Vascular Endothelial Growth Factor Receptor-1 - immunology | Antibodies, Monoclonal, Humanized - immunology | Original Paper
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2012, Volume 104, Issue 8, pp. 622 - 634
Background Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many cancers. Anti-EpCAM antibodies have shown promise in preclinical studies,... 
BREAST-CANCER | STEM-CELLS | ONCOLOGY | MR 34,000 | PROSTATE-CANCER PATIENTS | EP-CAM | ALPHA-AMANITIN | SURFACE GLYCOPROTEIN | FUSION PROTEIN | DEPENDENT RNA POLYMERASES | ANTITUMOR-ACTIVITY | Immunohistochemistry | Liver - enzymology | Colonic Neoplasms - drug therapy | Humans | Cell Adhesion Molecules - immunology | Alpha-Amanitin - immunology | Epithelial Cell Adhesion Molecule | Immunoconjugates - immunology | Pancreatic Neoplasms - drug therapy | Immunoconjugates - pharmacology | Flow Cytometry | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Carcinoma - drug therapy | Antigens, Neoplasm - immunology | Antineoplastic Agents - immunology | Carcinoma - immunology | Antibodies, Monoclonal - pharmacology | Pancreatic Neoplasms - pathology | Alpha-Amanitin - pharmacology | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Enzyme Inhibitors - immunology | Mice, SCID | Cell Adhesion Molecules - metabolism | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Animals | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Biomarkers, Tumor - immunology | Chimera | Monoclonal antibodies | Care and treatment | Dosage and administration | Research | Pancreatic cancer | Cell adhesion molecules
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 11/2016, Volume 13, Issue 11, pp. 659 - 673
Metronomic chemotherapy describes the close, regular administration of chemotherapy drugs at less-toxic doses over prolonged periods of time. In 2015, the... 
IN-VITRO | ANTIANGIOGENIC ACTIVITY | ONCOLOGY | RANDOMIZED PHASE-II | BREAST-CANCER PATIENTS | ANTITUMOR INNATE IMMUNITY | ORAL TOPOTECAN | CYCLOPHOSPHAMIDE TREATMENT | ANTICANCER DRUGS | CLINICAL PHARMACOKINETICS | DOSE CHEMOTHERAPY | Angiogenesis Inhibitors - immunology | Pyrimidines - immunology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Administration, Metronomic | Breast Neoplasms - immunology | Alkylating Agents - immunology | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Angiogenesis Inhibitors - administration & dosage | Clinical Trials, Phase III as Topic | Colorectal Neoplasms - drug therapy | Tubulin Modulators - administration & dosage | Alkylating Agents - pharmacokinetics | Camptothecin - administration & dosage | Female | Camptothecin - immunology | Camptothecin - pharmacokinetics | Pyrimidines - administration & dosage | Tubulin Modulators - pharmacokinetics | Alkylating Agents - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - immunology | Breast Neoplasms - drug therapy | Forecasting | Randomized Controlled Trials as Topic | Immunity, Cellular - immunology | Colorectal Neoplasms - immunology | Tubulin Modulators - immunology | Pyrimidines - pharmacokinetics | Chemotherapy | Care and treatment | Patient outcomes | Forecasts and trends | Pharmacokinetics | Observations | Methods | Cancer | Index Medicus
Journal Article
Molecular Immunology, ISSN 0161-5890, 02/2012, Volume 50, Issue 1-2, pp. 35 - 41
► VEGFR2 is an important tumor-associated receptor on the endothelial cells. ► Blockade of the VEGFR2with nanobody lead to the inhibition of... 
VEGFR2 | Nanobody | Angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOGLOBULIN | IMMUNOLOGY | SINGLE-DOMAIN ANTIBODIES | DISCOVERY | FRAGMENTS | INHIBITION | THERAPY | RAMUCIRUMAB IMC-1121B | SELECTION | EXPRESSION | VEGF-RECEPTOR | Angiogenesis Inhibitors - immunology | Surface Plasmon Resonance | Neovascularization, Physiologic - drug effects | Humans | Human Umbilical Vein Endothelial Cells - immunology | Molecular Sequence Data | Male | Vascular Endothelial Growth Factor Receptor-2 - immunology | Signal Transduction - immunology | Human Umbilical Vein Endothelial Cells - physiology | Flow Cytometry | Single-Chain Antibodies - genetics | Antibody Specificity - immunology | HEK293 Cells | Amino Acid Sequence | Immune Sera - immunology | Human Umbilical Vein Endothelial Cells - drug effects | Single-Chain Antibodies - pharmacology | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Protein Binding - immunology | Neovascularization, Physiologic - immunology | Sequence Homology, Amino Acid | Camelids, New World | Angiogenesis Inhibitors - metabolism | Animals | Kinetics | Single-Chain Antibodies - immunology | Chemical properties | Neovascularization | Endothelial growth factors | Vascular endothelial growth factor | Human Umbilical Vein Endothelial Cells | Antibody Specificity | Immune Sera | Signal Transduction | Angiogenesis Inhibitors | Vascular Endothelial Growth Factor Receptor-2 | Life Sciences | Protein Binding | Genetics | Single-Chain Antibodies | Neovascularization, Physiologic
Journal Article
Cancer Research, ISSN 0008-5472, 06/2005, Volume 65, Issue 12, pp. 5144 - 5152
Pigment epithelial-derived factor (PEDF), an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor... 
CEREBELLAR GRANULE NEURONS | DIABETIC-RETINOPATHY | FACTOR PEDF | ONCOLOGY | IN-VIVO | NEUROENDOCRINE DIFFERENTIATION | MACULAR DEGENERATION | GENE-TRANSFER | CHOROIDAL NEOVASCULARIZATION | TUMOR-GROWTH | ENDOTHELIAL GROWTH-FACTOR | Angiogenesis Inhibitors - immunology | Eye Proteins - immunology | Epitope Mapping | Humans | Molecular Sequence Data | Male | Peptide Fragments - pharmacology | Prostatic Neoplasms - immunology | Corneal Neovascularization | Peptide Fragments - immunology | Neovascularization, Pathologic - prevention & control | Neovascularization, Pathologic - immunology | Epitopes - physiology | Prostatic Neoplasms - blood supply | Amino Acid Sequence | Prostatic Neoplasms - pathology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Transcription Factors - antagonists & inhibitors | Nerve Growth Factors - immunology | NFATC Transcription Factors | Endothelial Cells - immunology | Serpins - immunology | Cell Differentiation - immunology | Animals | Endothelial Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | CASP8 and FADD-Like Apoptosis Regulating Protein | Mice | Nuclear Proteins - physiology | Intracellular Signaling Peptides and Proteins - physiology
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 08/2017, Volume 18, Issue 8, p. 1786
Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is controlled by the complicated and coordinated actions of pro-angiogenic... 
Tumor angiogenesis | Tumor | Antibody | Cancer therapy | VEGF | Therapeutic target | antibody | LECTIN-LIKE DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOCYTE GROWTH-FACTOR | VESSEL MATURATION | therapeutic target | OPEN-LABEL | CHEMISTRY, MULTIDISCIPLINARY | MET RECEPTOR | CELL LUNG-CANCER | cancer therapy | RECEPTOR TYROSINE KINASES | tumor | tumor angiogenesis | TUMOR-GROWTH | PHASE-I | TIE2 RECEPTOR | Angiogenesis Inhibitors - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Bevacizumab - therapeutic use | Carcinogenesis - immunology | Humans | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasms - drug therapy | Neovascularization, Pathologic - pathology | Carcinogenesis - drug effects | Neoplasms - immunology | Neovascularization, Pathologic - drug therapy | Immunotherapy | Angiogenesis Inhibitors - therapeutic use | Neovascularization, Pathologic - immunology | Antibodies, Monoclonal, Humanized - immunology | Neoplasms - pathology | Therapy | Immunoglobulins | Target recognition | Drug resistance | Drug development | Cancer therapies | Bevacizumab | Metastases | Angiogenesis | Side effects | Receptors | Antiangiogenics | Monoclonal antibodies | Tumorigenesis | Vascular endothelial growth factor | Recombinant | Cancer | Tumors
Journal Article