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Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2011, Volume 10, Issue 12, pp. 2298 - 2308
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7541, pp. 102 - 105
The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leukaemia and 30-50% of cases of adult acute lymphoblastic leukaemia(1). Introduction of ABL1... 
MECHANISM | POSITIVE LEUKEMIA | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | FOLLOW-UP | PATIENTS RECEIVING IMATINIB | KINASE INHIBITOR | BCR-ABL INHIBITOR | CHRONIC MYELOID-LEUKEMIA | T315I MUTANT | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Molecular Conformation | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Angiogenesis Inhibitors - therapeutic use | Imidazoles - therapeutic use | Phosphorylation - drug effects | Fusion Proteins, bcr-abl - chemistry | Cell Line | Proto-Oncogene Proteins c-abl - genetics | Indazoles - chemistry | Crystallization | Proto-Oncogene Proteins c-abl - chemistry | Angiogenesis Inhibitors - pharmacology | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Imidazoles - pharmacology | Drug Repositioning | Indazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Fusion Proteins, bcr-abl - genetics | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Protein Kinase Inhibitors - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Protein Binding | Proto-Oncogene Proteins c-abl - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Kidney Neoplasms - drug therapy | Fusion Proteins, bcr-abl - metabolism | Indazoles - therapeutic use | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Axitinib | Genetic aspects | Research | Gene mutations | Drug resistance | Analysis | Phosphorylation | Inhibitor drugs | Leukemia | Bone marrow | Mutation | Kinases | Drug dosages | Patients | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 11/2009, Volume 101, Issue 10, pp. 1717 - 1723
Journal Article
Cancer Research, ISSN 0008-5472, 01/2008, Volume 68, Issue 1, pp. 206 - 215
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2007, Volume 6, Issue 7, pp. 2012 - 2021
With the development of targeted therapeutics, especially for small-molecule inhibitors, it is important to understand whether the observed in vivo efficacy... 
kinase inhibitor | Pharmacodynamics | pazopanib | angiogenesis | VEGF | TARGET | ONCOLOGY | FACTOR RECEPTORS | EXPRESSION | CANCER | TUMORS | RENAL-CELL CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Pyrimidines - blood | Humans | Fibroblast Growth Factor 2 - pharmacology | Antineoplastic Agents - administration & dosage | Indazoles - administration & dosage | Sulfones - pharmacology | Neovascularization, Pathologic - pathology | Phosphotyrosine - metabolism | Dose-Response Relationship, Drug | Sulfonamides - blood | Inhibitory Concentration 50 | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cornea - pathology | Phosphorylation - drug effects | Sulfones - blood | Vascular Endothelial Growth Factor A - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Pyrimidines - administration & dosage | Pyrimidines - pharmacology | Sulfones - pharmacokinetics | Sulfonamides - pharmacology | Protein Kinase Inhibitors - blood | Sulfonamides - pharmacokinetics | Indazoles - pharmacology | Protein Kinase Inhibitors - administration & dosage | Indazoles - blood | Animals | Indazoles - pharmacokinetics | Cell-Free System | Mice, Nude | Antineoplastic Agents - blood | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Mice | Protein Kinase Inhibitors - pharmacology | Sulfonamides - administration & dosage | Sulfones - administration & dosage | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 20, pp. 7066 - 7083
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2009, Volume 8, Issue 7, pp. 1725 - 1738
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2012, Volume 21, Issue 1, pp. 66 - 81
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 11/2012, Volume 527, Issue 2, pp. 81 - 89
Diets with high content of antioxidant polyphenols are associated with low prevalence of cardiovascular diseases and cancer. Inflammatory angiogenesis is a key... 
Polyphenols | Angiogenesis | Oxidative stress | COX-2 | Mediterranean diet | MMP-9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLOOXYGENASE-2 INDUCTION | TUMOR ANGIOGENESIS | OLIVE OIL POLYPHENOLS | MATRIX METALLOPROTEINASES | ANTIANGIOGENIC THERAPY | IN-VITRO | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLAQUE STABILITY | GROWTH-FACTOR | NF-KAPPA-B | Gene Expression Regulation, Enzymologic - drug effects | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Diet, Mediterranean | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Polyphenols - pharmacology | NF-kappa B - metabolism | Neoplasms - prevention & control | Olive Oil | Matrix Metalloproteinase Inhibitors - therapeutic use | Neovascularization, Pathologic - pathology | Neovascularization, Pathologic - enzymology | Matrix Metalloproteinase 9 - metabolism | Cyclooxygenase 2 Inhibitors - therapeutic use | Human Umbilical Vein Endothelial Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Antioxidants - pharmacology | Wine - analysis | Matrix Metalloproteinase Inhibitors - pharmacology | Antioxidants - therapeutic use | Human Umbilical Vein Endothelial Cells - enzymology | Neovascularization, Pathologic - drug therapy | Cyclooxygenase 2 - metabolism | Neovascularization, Pathologic - metabolism | Polyphenols - therapeutic use | Plant Oils - chemistry | Atherosclerosis - prevention & control | Inflammation - physiopathology | Wine | Antioxidants | COX-2 inhibitors | Blood circulation disorders | Oncology, Experimental | Resveratrol | Atherosclerosis | Research | Cells | Cancer | Endothelium | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18633 - 18640
Journal Article