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Journal of Cellular Physiology, ISSN 0021-9541, 02/2008, Volume 214, Issue 2, pp. 491 - 503
Endothelial cells are constantly exposed to high or low shear stress in arteries and veins by the flowing blood. Angiopoietin‐2 (Ang‐2) is acting as a critical... 
OXIDATIVE STRESS | PHYSIOLOGY | RECEPTOR TYROSINE KINASES | ANGIOGENESIS | FLUID SHEAR-STRESS | NITRIC-OXIDE SYNTHASE | GROWTH-FACTOR | FOXO TRANSCRIPTION FACTORS | EXPRESSION | HUMAN ENDOTHELIAL-CELLS | TIE2 RECEPTOR | CELL BIOLOGY | Humans | Rifabutin - analogs & derivatives | RNA, Messenger - analysis | Stress, Mechanical | Culture Media, Serum-Free | Endothelium, Vascular - drug effects | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Angiopoietin-2 - metabolism | Nitric Oxide - analysis | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Forkhead Transcription Factors - metabolism | Triazenes - pharmacology | Receptor, TIE-2 - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Umbilical Veins - cytology | Vascular Endothelial Growth Factor A - pharmacology | Angiopoietin-1 - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Morpholines - pharmacology | Cell Separation - methods | Lactams, Macrocyclic - pharmacology | Regional Blood Flow | Nitric Oxide Synthase Type III - antagonists & inhibitors | Benzoquinones - pharmacology | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Forkhead Transcription Factors - analysis | Proto-Oncogene Proteins c-akt - analysis | Femoral Artery - physiology | Forkhead Box Protein O1 | Mice | Nitrites - analysis | Angiopoietin-2 - secretion | Dactinomycin - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2012, Volume 26, Issue 12, pp. 4876 - 4885
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late... 
Proteases | Vascular smooth muscle cells | Angiogenic growth factors | TROPHOBLAST INVASION | GRANULATED LYMPHOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | proteases | CELL BIOLOGY | angiogenic growth factors | EXTRAVILLOUS TROPHOBLAST | SMOOTH-MUSCLE | IN-VITRO | BIOLOGY | CARDIOVASCULAR-DISEASE | MATERNAL ARTERIES | GROWTH-FACTOR | vascular smooth muscle cells | EXPRESSION | FACTS | Immunohistochemistry | Muscle, Smooth, Vascular - metabolism | Decidua - cytology | Humans | Extracellular Matrix - metabolism | Culture Media, Conditioned - pharmacology | Interferon-gamma - metabolism | Angiopoietin-1 - metabolism | Angiopoietin-2 - pharmacology | Angiopoietin-2 - metabolism | Uterine Artery - physiology | Placenta - cytology | Myometrium - metabolism | Female | Trophoblasts - cytology | Uterine Artery - drug effects | Myocytes, Smooth Muscle - drug effects | Uterus - blood supply | Myocytes, Smooth Muscle - metabolism | Angiopoietin-1 - pharmacology | Cell Line | Trophoblasts - metabolism | Uterine Artery - cytology | Tissue Culture Techniques | Extracellular Matrix - drug effects | Cells, Cultured | Muscle, Smooth, Vascular - cytology | Killer Cells, Natural - physiology | Decidua - metabolism | Myometrium - cytology | Placenta - metabolism | Pregnancy | Trophoblasts - physiology | Vascular Endothelial Growth Factor C - metabolism | Uterus - cytology | Killer Cells, Natural - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Vascular Endothelial Growth Factor C - pharmacology
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2015, Volume 65, Issue 2, pp. 501 - 508.e1
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 36, pp. 9201 - 9209
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2007, Volume 27, Issue 12, pp. 2619 - 2626
OBJECTIVE—Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis. Previous studies have demonstrated that Tie2 is... 
Phosphoinositide 3-kinase | Akt | Tie2 | VEGF | Endothelium | endothelium | ACTIVATION | ANGIOGENESIS | TYROSINE KINASE | SOLUBLE TIE | GROWTH-FACTOR LEVELS | HUMAN ENDOTHELIAL-CELLS | OVEREXPRESSING ANGIOPOIETIN-1 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ANGIOPOIETIN RECEPTOR TIE-2 | EXPRESSION | phosphoinositide 3-kinase | PLASMA ANGIOPOIETIN-1 | NIH 3T3 Cells | Neovascularization, Physiologic - drug effects | Fibroblasts - enzymology | Phosphorylation | Tetradecanoylphorbol Acetate - pharmacology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Angiopoietin-1 - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Angiopoietin-2 - metabolism | Transfection | Receptor, TIE-2 - blood | Peptide Fragments - blood | Receptor, TIE-2 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Peptide Fragments - genetics | Fibroblasts - metabolism | Peptide Hydrolases - metabolism | PTEN Phosphohydrolase - genetics | Peptide Fragments - metabolism | Endothelial Cells - metabolism | Dipeptides - pharmacology | Cells, Cultured | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Imidazoles - pharmacology | Receptor, TIE-2 - genetics | Animals | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Matrix Metalloproteinase Inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Matrix Metalloproteinases - metabolism | Endothelial Cells - pathology | Endothelial Cells - enzymology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Endothelial Cells - drug effects
Journal Article
Cancer Research, ISSN 0008-5472, 03/2010, Volume 70, Issue 6, pp. 2213 - 2223
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 31, pp. 7897 - 7904
Journal Article
European Journal of Haematology, ISSN 0902-4441, 03/2010, Volume 84, Issue 3, pp. 239 - 251
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2002, Volume 99, Issue 17, pp. 11205 - 11210
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107146
CD248 (Endosialin) is a type 1 membrane protein involved in developmental and pathological angiogenesis through its expression on pericytes and regulation of... 
ANGIOPOIETINS | MARKER | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | IN-VIVO | PERICYTE LOSS | BLOOD-VESSEL FORMATION | MICE | GROWTH-FACTOR | TUMORS | BETA | Neovascularization, Physiologic - drug effects | Pericytes - drug effects | Angiopoietin-2 - genetics | Capillaries - drug effects | Muscle, Skeletal - metabolism | Neoplasm Proteins - metabolism | Angiopoietin-2 - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Prazosin - pharmacology | Muscle, Skeletal - drug effects | Benzamides - pharmacology | Neoplasm Proteins - genetics | Capillaries - metabolism | Muscle, Skeletal - blood supply | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neovascularization, Physiologic - genetics | Pericytes - metabolism | Receptors, Platelet-Derived Growth Factor - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Knockout | Up-Regulation - drug effects | Platelet-Derived Growth Factor - metabolism | Animals | Signal Transduction - drug effects | Receptors, Platelet-Derived Growth Factor - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Muscles | Gene expression | Platelet-derived growth factor | Systems science | Phosphorylation | Angiopoietin | Smooth muscle | Kinases | Defects | Angiogenesis | Blood platelets | Rodents | Physiology | Growth factors | Protein-tyrosine kinase | Tyrosine | Imatinib | Rheumatology | Inflammation | Endothelial cells | Skeletal muscle | Membrane proteins | Musculoskeletal system | Signaling | Splitting | Shear stress | Pericytes | Mechanical stimuli | Binding sites
Journal Article
Journal Article
PLoS One, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23448
Background: Angiopoietin-2 (Ang-2) is associated with lung injury in ALI/ARDS. As endothelial activation by thrombin plays a role in the permeability of acute... 
INDUCED INCREASE | TIE2 | IN-VIVO | JUNCTIONS | KINASE | BIOLOGY | BARRIER FUNCTION | ACUTE LUNG INJURY | VE-CADHERIN | GENE-THERAPY | VASCULAR-PERMEABILITY | Angiopoietins - pharmacology | Cadherins - metabolism | Angiopoietin-2 - genetics | Humans | Immunoblotting | rhoA GTP-Binding Protein - metabolism | Angiopoietin-1 - metabolism | Angiopoietin-2 - pharmacology | Angiopoietin-2 - metabolism | Antigens, CD - metabolism | Thrombin - pharmacology | Time Factors | Coagulants - pharmacology | Receptor, TIE-2 - metabolism | Phosphorylation - drug effects | Endothelial Cells - physiology | Angiopoietin-1 - pharmacology | Angiopoietins - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Electric Impedance | Recombinant Proteins - pharmacology | Angiopoietin-1 - genetics | Cell Membrane Permeability - drug effects | Angiopoietins - genetics | Lung - blood supply | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | Acute respiratory distress syndrome | Thrombin | Permeability | G proteins | Endothelium | Phosphorylation | Intensive care | Angiopoietin | Cell junctions | Activation | Kinases | Experiments | Angiogenesis | Cell activation | Cell growth | Rodents | Physiology | Vascular endothelial growth factor | Medical research | RhoA protein | Rac1 protein | Inflammation | Cadherin | Endothelial cells | Lungs | Nitric oxide | Ligands | Microvasculature | Kinetics | Destabilization | Electrical junctions
Journal Article