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index medicus (708) 708
humans (632) 632
animals (440) 440
angiopoietin-like proteins (349) 349
mice (348) 348
male (341) 341
angiopoietin-like 4 protein (306) 306
female (306) 306
angiopoietins - genetics (270) 270
angiopoietins - metabolism (265) 265
biochemistry & molecular biology (187) 187
metabolism (186) 186
expression (181) 181
middle aged (180) 180
endocrinology & metabolism (166) 166
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physiological aspects (138) 138
gene expression (137) 137
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cell biology (124) 124
lipids (123) 123
insulin-resistance (120) 120
lipoprotein lipase (120) 120
angiopoietin (118) 118
glucose (118) 118
lipoprotein-lipase (116) 116
angptl4 (113) 113
insulin resistance (113) 113
mice, inbred c57bl (112) 112
angiopoietin-like 4 (108) 108
inflammation (105) 105
triglycerides (103) 103
analysis (101) 101
diabetes (101) 101
lipid-metabolism (101) 101
article (100) 100
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multidisciplinary sciences (92) 92
liver (89) 89
lipid metabolism (86) 86
cholesterol (85) 85
genetic aspects (85) 85
research article (84) 84
risk factors (84) 84
triglycerides - blood (83) 83
adipose-tissue (79) 79
angiopoietins (78) 78
target gene (78) 78
insulin (77) 77
oncology (77) 77
health aspects (76) 76
betatrophin (75) 75
metastasis (74) 74
angiopoietin-like protein-4 (73) 73
angptl3 (73) 73
peptide hormones - blood (73) 73
cell line, tumor (72) 72
mice, knockout (72) 72
gene-expression (71) 71
angiopoietin-like protein (70) 70
lipoprotein lipase - metabolism (70) 70
enzyme-linked immunosorbent assay (69) 69
inhibition (69) 69
rodents (69) 69
signal transduction (69) 69
angiopoietins - blood (68) 68
atherosclerosis (68) 68
cells, cultured (68) 68
gene (68) 68
medicine (68) 68
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physiology (65) 65
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case-control studies (63) 63
gene expression regulation (63) 63
lipase (63) 63
liver - metabolism (63) 63
type 2 diabetes (62) 62
fatty acids (60) 60
rats (60) 60
protein (58) 58
risk (57) 57
rna, messenger - metabolism (56) 56
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abridged index medicus (53) 53
angiopoietin-like protein 4 (53) 53
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 26, pp. E6020 - E6029
The intravascular processing of triglyceride-rich lipoproteins depends on lipoprotein lipase (LPL) and GPIHBP1, a membrane protein of endothelial cells that... 
Intrinsically disordered | Autoimmune disease | Region | Electrostatic steering | Hypertriglyceridemia | Intravascular lipolysis | electrostatic steering | intrinsically disordered region | TRIGLYCERIDE-METABOLISM | MULTIDISCIPLINARY SCIENCES | hypertriglyceridemia | GRADIENT FORMATION | autoimmune disease | intravascular lipolysis | PREDICTION | CAPILLARIES | AFFINITY | KINETICS | REGIONS | BINDING PROTEIN-1 | UROKINASE RECEPTOR | MICE | Endothelial Cells - metabolism | Lipoprotein Lipase - genetics | Humans | Receptors, Lipoprotein - genetics | Hyperlipoproteinemia Type I - genetics | Receptors, Lipoprotein - metabolism | Receptors, Lipoprotein - chemistry | Tyrosine - metabolism | Animals | Hyperlipoproteinemia Type I - pathology | Angiopoietin-like 4 Protein - metabolism | Protein Binding | Protein Domains | Mice | Hyperlipoproteinemia Type I - metabolism | Lipoprotein Lipase - chemistry | Angiopoietin-like 4 Protein - chemistry | Endothelial Cells - pathology | Lipoprotein Lipase - metabolism | Tyrosine - chemistry | Angiopoietin-like 4 Protein - genetics | Tyrosine - genetics | Tyrosine | Physiological aspects | Physiological research | Lipoprotein lipase | Research | Biological control systems | Binding proteins | Biological Sciences | PNAS Plus | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H. Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca A and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas J and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper and Diabetes - Cardiovascular Disease and Cardiovascular Research - Hypertension and Kardiovaskulär forskning - hypertoni and Diabetes - kardiovaskulär sjukdom and Lund University and Genomics, Diabetes and Endocrinology and EpiHealth: Epidemiology for Health and Genomik, diabetes och endokrinologi and Institutionen för kliniska vetenskaper, Malmö and Lunds universitet and Department of Clinical Sciences, Malmö
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2252 - 11
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient... 
HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | MULTIDISCIPLINARY SCIENCES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | HAN CHINESE | CHINESE POPULATION | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - genetics | Humans | Homeostasis | Male | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Genetic Variation | Diabetes Mellitus, Type 2 - etiology | Female | Lipoprotein Lipase - metabolism | Genetic Association Studies | Mice, Inbred C57BL | Risk Factors | Gene Silencing | Angiopoietin-like 4 Protein - deficiency | Mice, Knockout | Whole Exome Sequencing | Animals | Insulin Resistance - genetics | Angiopoietin-like 4 Protein - metabolism | Heterozygote | Mice | Blood Glucose - metabolism | Amino Acid Substitution | Angiopoietin-like 4 Protein - genetics | Deactivation | Angiopoietin | Diabetes mellitus | Health risks | Risk reduction | Risk | Lipoprotein lipase | Glucose | Lipase | Inactivation | Insulin | Proteins | Confidence intervals | Sensitivity | Nutrient loss | Rodents | Arteriosclerosis | Atherosclerosis | Genetics | Diabetes | Diabetes mellitus (non-insulin dependent) | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Molecular Cancer, ISSN 1476-4598, 10/2018, Volume 17, Issue 1, pp. 152 - 8
Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role... 
Epithelial-mesenchymal transition | Angiopoietin-like 4 | ATP-binding cassette transporters | Multi-drug resistance | TO-MESENCHYMAL TRANSITION | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | CHEMORESISTANCE | Neoplasms - metabolism | Angiopoietin-like 4 Protein - antagonists & inhibitors | Humans | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Epithelial-Mesenchymal Transition - genetics | Neoplasms - drug therapy | Animals | ATP-Binding Cassette Transporters - genetics | Neoplasms - genetics | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Angiopoietin-like 4 Protein - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Energy Metabolism - drug effects | Angiopoietin-like 4 Protein - genetics | Cancer patients | Chemotherapy | Usage | Diagnosis | Health aspects | Cancer | Drugs | Transcription | Mesenchyme | Angiopoietin | Chemoresistance | Metastasis | Myc protein | Drug resistance | Energy requirements | Experiments | Flexibility | Cancer therapies | Metastases | Proteins | Energy | ABC transporters | Deoxyribonucleic acid--DNA | Adducts | Efflux | NF-κB protein | Deprivation | Multidrug resistance | Metabolism | Gene expression | Cisplatin | Hypoxia | DNA adducts | Protein structure | Tumors | Apoptosis
Journal Article
Nature Communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, p. 12313
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report... 
EX-VIVO EXPANSION | CORONARY PLAQUE | STEM-CELLS | CHOLESTEROL ACCUMULATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LOW-DENSITY-LIPOPROTEIN | SCAVENGER RECEPTORS | ANGIOPOIETIN-LIKE PROTEIN-4 | KNOCKOUT MICE | TARGET GENE
Journal Article
Lymphatic Research and Biology, ISSN 1539-6851, 02/2018, Volume 16, Issue 1, pp. 43 - 55
Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene expression... 
PIK3CA | endothelial cells | lymphatic malformations | Interleukin-8 - genetics | Heme Oxygenase-1 - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Vesicular Transport Proteins - metabolism | Humans | Aminoimidazole Carboxamide - pharmacology | Cyclooxygenase 2 - genetics | E-Selectin - genetics | Lipid Metabolism - genetics | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Repressor Proteins - metabolism | Histone Deacetylases - genetics | Interleukin-6 - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Lymphoid Tissue - metabolism | Repressor Proteins - genetics | Lymphatic Abnormalities - pathology | Lymphoid Tissue - pathology | Aminoimidazole Carboxamide - analogs & derivatives | Vascular Endothelial Growth Factor C - metabolism | Angiopoietin-like 4 Protein - metabolism | Mutation | Endothelial Cells - pathology | Autophagy-Related Proteins - metabolism | AMP-Activated Protein Kinases - genetics | Angiopoietin-like 4 Protein - genetics | Lymphatic Abnormalities - genetics | AMP-Activated Protein Kinases - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Ribonucleotides - pharmacology | Heme Oxygenase-1 - genetics | Membrane Proteins - metabolism | Autophagy-Related Proteins - genetics | Cell Line | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Lymphatic Abnormalities - metabolism | E-Selectin - metabolism | Histone Deacetylases - metabolism | Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Transcription Factors - metabolism | Ankyrins - genetics | Alleles | Ankyrins - metabolism | Cyclooxygenase 2 - metabolism | Primary Cell Culture | Endothelial Cells - drug effects
Journal Article
Science signaling, ISSN 1945-0877, 07/2017, Volume 10, Issue 489, p. eaai7905
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 44351
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 43199
In healthy subjects, the intestinal microbiota interacts with the host's epithelium, regulating gene expression to the benefit of both, host and microbiota.... 
COLON-CANCER | INFLAMMATORY-BOWEL-DISEASE | IMMUNE-SYSTEM | METABOLISM | CHAIN FATTY-ACIDS | MULTIDISCIPLINARY SCIENCES | ACTIVATED-RECEPTOR-GAMMA | RESISTANCE | MICROBIOTA | KINASE ACTIVATION | EXPRESSION
Journal Article