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angiopoietins - genetics (342) 342
index medicus (286) 286
humans (256) 256
animals (219) 219
angiopoietins - metabolism (211) 211
mice (172) 172
angiopoietin-like 4 protein (156) 156
angiopoietin-like proteins (124) 124
male (122) 122
female (111) 111
biochemistry & molecular biology (83) 83
angiogenesis (82) 82
expression (73) 73
gene expression (72) 72
cell biology (61) 61
middle aged (56) 56
angiopoietin (51) 51
cell line, tumor (47) 47
mice, inbred c57bl (47) 47
oncology (46) 46
proteins (45) 45
research (43) 43
lipoprotein-lipase (42) 42
metabolism (42) 42
research article (42) 42
rna, messenger - metabolism (42) 42
cells, cultured (41) 41
angptl4 (40) 40
adult (39) 39
cell line (39) 39
endocrinology & metabolism (38) 38
mice, knockout (38) 38
article (37) 37
inflammation (37) 37
signal transduction (37) 37
aged (36) 36
physiological aspects (36) 36
rna, messenger - genetics (36) 36
obesity (35) 35
gene-expression (32) 32
vascular endothelial growth factor a - genetics (32) 32
medicine (31) 31
rodents (31) 31
target gene (31) 31
gene expression regulation (30) 30
genetic aspects (30) 30
triglycerides (30) 30
triglycerides - blood (30) 30
vascular endothelial growth factor (30) 30
analysis (29) 29
genes (29) 29
inhibition (29) 29
metastasis (29) 29
lipids (27) 27
lipoprotein lipase - metabolism (27) 27
multidisciplinary sciences (27) 27
reverse transcriptase polymerase chain reaction (27) 27
cancer (26) 26
cells (26) 26
lipid-metabolism (26) 26
angiopoietins - biosynthesis (25) 25
gene expression regulation, neoplastic (25) 25
in-vivo (25) 25
lipoprotein lipase (25) 25
mutation (25) 25
science (25) 25
vascular endothelial growth factor a - metabolism (25) 25
blotting, western (24) 24
genetics (24) 24
kinases (24) 24
liver - metabolism (24) 24
adipose-tissue (23) 23
hematology (23) 23
hypoxia (23) 23
physiology (23) 23
angiopoietin-like 4 (22) 22
angiopoietins - blood (22) 22
biology (22) 22
cholesterol (22) 22
disease models, animal (22) 22
growth (22) 22
lipase (22) 22
peripheral vascular disease (22) 22
rats (22) 22
receptor (22) 22
up-regulation (22) 22
genetics & heredity (21) 21
insulin-resistance (21) 21
lipoprotein lipase - genetics (21) 21
rna (21) 21
abridged index medicus (20) 20
gene (20) 20
lipid metabolism (20) 20
neovascularization, pathologic - genetics (20) 20
receptor, tie-2 - genetics (20) 20
transfection (20) 20
angptl3 (19) 19
apoptosis (19) 19
developmental biology (19) 19
endothelium (19) 19
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Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 38, pp. 25593 - 25601
Glucocorticoids are important regulators of lipid homeostasis, and chronically elevated glucocorticoid levels induce hypertriglyceridemia, hepatic steatosis,... 
OBESITY | PLASMA | GENE | CHROMATIN | ANGIOGENESIS | DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERLIPIDEMIA | MICE | TRANSCRIPTIONAL REGULATION | PROTEIN-4 | Transcription, Genetic - drug effects | Hypertriglyceridemia - genetics | Humans | Dexamethasone - adverse effects | Receptors, Glucocorticoid - metabolism | Hepatocytes - metabolism | Fatty Liver - chemically induced | Adipose Tissue - metabolism | Angiopoietin-like 4 Protein | Dexamethasone - pharmacology | Glucocorticoids - genetics | Glucocorticoids - metabolism | Response Elements - genetics | Lipoprotein Lipase - metabolism | Glucocorticoids - adverse effects | Fatty Liver - genetics | Angiopoietins - metabolism | Fatty Liver - metabolism | Lipoprotein Lipase - genetics | Liver - metabolism | Rats | Hypertriglyceridemia - metabolism | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue, White | Hypertriglyceridemia - chemically induced | Animals | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Dexamethasone - metabolism | Glucocorticoids - pharmacology | Mice | Transcription, Genetic - genetics | Triglycerides - genetics | Angiopoietins - genetics | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling | Transcription | Dermatologi och venereologi | Dermatology and Venereal Diseases | Dexamethasone/adverse effects/metabolism/pharmacology | Hypertriglyceridemia/chemically induced/genetics/metabolism | Receptors | Adipose Tissue/metabolism | Liver/metabolism | Tumor | Adipose Tissue | Cell Line | Fatty Liver/chemically induced/genetics/metabolism | Triglycerides/genetics/ metabolism | Response Elements/genetics | Angiopoietins/genetics/ metabolism | Knockout | Lipoprotein Lipase/genetics/metabolism | White | Hepatocytes/metabolism | Genetic/drug effects/genetics | Glucocorticoids/adverse effects/genetics/ metabolism/pharmacology | Glucocorticoid/genetics/ metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2014, Volume 34, Issue 4, pp. 790 - 800
OBJECTIVE—Cardiovascular disease (CVD), the most common morbidity resulting from atherosclerosis, remains a frequent cause of death. Efforts to develop... 
atherosclerosis | endothelium-derived vasoconstrictor factors | cardiovascular diseases | inflammation | INHIBITION | ANGIOPOIETIN-LIKE PROTEIN-2 | DISEASE | RISK | PERIPHERAL VASCULAR DISEASE | MECHANISMS | HEMATOLOGY | PREDICTION | Chemotaxis, Leukocyte | Vasculitis - metabolism | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Vasculitis - prevention & control | Vasodilation | Vasculitis - genetics | Time Factors | Diet, High-Fat | Bone Marrow Transplantation | Aged, 80 and over | Disease Models, Animal | Endothelium, Vascular - immunology | Atherosclerosis - pathology | Atherosclerosis - immunology | Signal Transduction | Endothelial Cells - metabolism | Angiopoietins - deficiency | Obesity - physiopathology | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Disease Progression | Mice, Knockout | Macrophages - metabolism | Endothelium, Vascular - metabolism | Dyslipidemias - metabolism | Endothelium, Vascular - pathology | Mice | Endothelial Cells - pathology | Integrin alpha5beta1 - metabolism | Vasculitis - pathology | Monocytes - metabolism | Vasculitis - immunology | Angiopoietin-like Proteins | Inflammation Mediators - metabolism | Female | Macrophages - immunology | Angiopoietins - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Endothelium, Vascular - physiopathology | Obesity - metabolism | Endothelial Cells - immunology | Animals | Apolipoproteins E - genetics | Angiopoietins - genetics | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Dyslipidemias - physiopathology
Journal Article
Journal Article
Food and Function, ISSN 2042-6496, 5/2014, Volume 5, Issue 6, pp. 1241 - 1249
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16122 - 16134
Angptl4 (Angiopoietin-like 4) is a circulating protein secreted by white and brown adipose tissues and the liver. Structurally, Angptl4 contains an N-terminal... 
ADIPOCYTES | GENE | BEIGE FAT DEVELOPMENT | INSULIN-RESISTANCE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPROVES GLUCOSE-TOLERANCE | MICE | ANGPTL4 | LIPOPROTEIN-LIPASE | BROWN FAT | Up-Regulation | Liver - enzymology | Adipose Tissue, Beige - pathology | Male | Muscle, Skeletal - metabolism | Obesity - blood | Recombinant Fusion Proteins - metabolism | Angiopoietin-like 4 Protein | Adiposity | Peptide Fragments - blood | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Angiopoietins - metabolism | Muscle, Skeletal - enzymology | Peptide Fragments - metabolism | Abdominal Fat - pathology | Adipose Tissue, Beige - cytology | Liver - metabolism | Mice, Inbred C57BL | Oligopeptides - genetics | Cells, Cultured | Mice, Transgenic | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Angiopoietins - blood | Lipolysis | Recombinant Fusion Proteins - blood | Obesity - metabolism | Obesity - pathology | Triglycerides - metabolism | Abdominal Fat - metabolism | Peptide Fragments - chemistry | Abdominal Fat - cytology | Animals | Angiopoietins - chemistry | Energy Metabolism | Models, Biological | Obesity - prevention & control | Triglycerides - blood | Mutation | Angiopoietins - genetics | Adipose Tissue, Beige - metabolism | Index Medicus | type 2 diabetes | angiopoietin-like | adipocyte | Energy expenditure | Metabolism | metabolic disease | obesity
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2016, Volume 291, Issue 14, pp. 7373 - 7385
Choroidal neovascularization (CNV) is a pathogenic process of age-related macular degeneration, a vision-threatening disease. The retinal pigment epithelium... 
METABOLIC SYNDROME | IN-VITRO | METASTASIS | INTEGRIN ALPHA-5-BETA-1 | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE | EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION | MICE | GENERAL JAPANESE POPULATION | EXPRESSION | Inflammation - pathology | Humans | Transforming Growth Factor beta1 - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Integrin alpha4 - genetics | Angiopoietin-like Proteins | Choroidal Neovascularization - pathology | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Inflammation Mediators - metabolism | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Disease Models, Animal | Cell Line | Angiopoietins - biosynthesis | Interleukin-6 - genetics | Macrophages - pathology | CD18 Antigens - genetics | Chemokine CCL2 - genetics | Transforming Growth Factor beta1 - genetics | CD18 Antigens - metabolism | Macular Degeneration - metabolism | Macrophages - metabolism | Animals | Choroidal Neovascularization - metabolism | Integrin alpha4 - metabolism | Macular Degeneration - genetics | Inflammation - genetics | Mice | Angiopoietins - genetics | Choroidal Neovascularization - genetics | Macular Degeneration - pathology | extracellular-signal-regulated kinase (ERK) | inflammatory mediators | Molecular Bases of Disease | inflammation | choroidal neovascularization | migration | macrophage | NF-kappa B (NF-KB) | integrin | age-related macular degeneration | angiopoietin-like protein 2
Journal Article
Circulation Research, ISSN 0009-7330, 06/2010, Volume 106, Issue 11, pp. 1712 - 1721
RATIONALE:Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in... 
Peroxisome proliferator-activated receptor | Angptl4 | Cardiac oxidative stress | Gene expression | Fatty acids | CARDIAC & CARDIOVASCULAR SYSTEMS | fatty acids | MOUSE HEART | TRIGLYCERIDE-METABOLISM | ALPHA | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | cardiac oxidative stress | TARGET GENES | PLASMA | LIPOTOXIC CARDIOMYOPATHY | GENE-EXPRESSION | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | peroxisome proliferator-activated receptor | HEMATOLOGY | gene expression | Dietary Fats - metabolism | Up-Regulation | Linoleic Acid - metabolism | Cardiomyopathies - prevention & control | Male | Cardiomyopathies - genetics | Angiopoietin-like 4 Protein | RNA Interference | Time Factors | Myocardium - metabolism | Dietary Fats - administration & dosage | PPAR delta - genetics | Cytoprotection | Animals, Newborn | Angiopoietins - metabolism | Oleic Acid - metabolism | PPAR delta - deficiency | PPAR-beta - metabolism | Mice, Inbred C57BL | Cells, Cultured | Oxidative Stress - genetics | Angiopoietins - deficiency | Dietary Fats - blood | Fatty Acids, Unsaturated - metabolism | PPAR-beta - genetics | PPAR-beta - deficiency | Mice, Knockout | Fatty Acids, Unsaturated - blood | Fatty Acids, Unsaturated - toxicity | Feedback, Physiological | Animals | Cardiomyopathies - metabolism | alpha-Linolenic Acid - metabolism | Mice | PPAR delta - metabolism | Angiopoietins - genetics | Lipid Peroxidation | Dietary Fats - toxicity | Cardiomyopathies - chemically induced | Fatty Acids, Unsaturated - administration & dosage
Journal Article
Kidney International, ISSN 0085-2538, 08/2015, Volume 88, Issue 2, pp. 262 - 275
Tubulointerstitial hypoxia plays a critical role in the pathogenesis of kidney injury, and hypoxia-inducible factor (HIF)-1 is a master regulator of cellular... 
hypoxia | proximal tubule | inflammation | cell signaling | TRANSCRIPTION FACTORS | INDUCIBLE FACTOR | TUBULOINTERSTITIAL INJURY | 3 C/EBP ISOFORMS | INDUCTION | CANCER | PHASE | PATHWAY | GENE-EXPRESSION | UROLOGY & NEPHROLOGY | KIDNEY | Up-Regulation | Cell Hypoxia - physiology | Heme Oxygenase-1 - metabolism | Superoxide Dismutase - genetics | Kidney - pathology | Nephritis - genetics | Epithelial Cells - drug effects | Humans | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Gene Knockdown Techniques | Hypoxia - metabolism | Heme Oxygenase-1 - genetics | Angiopoietin-like 4 Protein | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Inflammation Mediators - pharmacology | Microarray Analysis | Transcription, Genetic | CCAAT-Enhancer-Binding Protein-delta - metabolism | Reperfusion Injury - complications | Superoxide Dismutase - metabolism | Kidney Tubules, Proximal - cytology | Angiopoietins - metabolism | Gene Expression | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Hypoxia - etiology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Renal Artery Obstruction - complications | Animals | Nephrectomy - adverse effects | CCAAT-Enhancer-Binding Protein-delta - genetics | Kidney Tubules, Proximal - metabolism | Cisplatin - adverse effects | Nephritis - metabolism | Mice | RNA, Small Interfering | Superoxide Dismutase-1 | Angiopoietins - genetics | Cell Hypoxia - genetics | Basic Research
Journal Article
Cell Metabolism, ISSN 1550-4131, 2009, Volume 10, Issue 3, pp. 178 - 188
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80544
Somatic mutations or loss of expression of tumor suppressor VHL happen in the vast majority of clear cell Renal Cell Carcinoma, and it's causal for kidney... 
HYPOXIA-INDUCIBLE FACTOR | BREAST-CANCER CELLS | INHIBITION | THERAPY | FACTOR-BINDING PROTEIN-3 | PROLYL HYDROXYLATION | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | PROLINE HYDROXYLATION | VHL | RENAL-CELL CARCINOMA | Insulin-Like Growth Factor Binding Protein 3 - genetics | Cyclin D1 - metabolism | Receptor, IGF Type 1 - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Glucose Transporter Type 1 - metabolism | Phosphopyruvate Hydratase - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Hypoxia-Inducible Factor 1 - metabolism | Angiopoietin-like 4 Protein | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Phosphopyruvate Hydratase - genetics | Tumor Burden - genetics | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Disease Models, Animal | Angiopoietins - metabolism | Carcinoma, Renal Cell - pathology | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Gene Knockout Techniques | Receptor, IGF Type 1 - genetics | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Animals | Cyclin D1 - genetics | Glucose Transporter Type 1 - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Cell Line, Tumor | Mice | Angiopoietins - genetics | RNA | Growth | Analysis | Genetic research | Development and progression | Disease susceptibility | Vascular endothelial growth factor | Cancer | Cell culture | Syngeneic grafts | Genes | Biology | Insulin-like growth factors | Glucose | Kinases | Cancer therapies | Proteins | Allografts | Insulin-like growth factor I receptors | Cell cycle | Xenografts | Insulin-like growth factor-binding protein 3 | Immunoglobulins | Breast cancer | Metabolism | Gene expression | Insulin | Pathology | Depletion | Kidney cancer | Tumor suppressor genes | Hypoxia | VHL protein | Mutation | Clear cell-type renal cell carcinoma | Apoptosis | Tumors
Journal Article
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 9/2011, Volume 462, Issue 3, pp. 469 - 477
Journal Article