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Kidney International, ISSN 0085-2538, 07/2014, Volume 86, Issue 1, pp. 75 - 85
Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic... 
Smad2 | kidney disease | TGF-β | fibrosis | relaxin | AT2 receptor | KIDNEY-DISEASE | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | RESONANCE ENERGY-TRANSFER | FIBROBLASTS | TGF-beta | GROWTH-FACTOR-BETA | AT RECEPTORS | IN-VIVO | UROLOGY & NEPHROLOGY | HYPERTENSIVE-RATS | HORMONE RELAXIN | Relaxin - metabolism | Kidney - pathology | Receptors, G-Protein-Coupled - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Protein Multimerization | Male | Receptors, Peptide - chemistry | Angiotensin II Type 2 Receptor Blockers - pharmacology | Relaxin - pharmacology | Renal Insufficiency, Chronic - drug therapy | Myofibroblasts - metabolism | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Myofibroblasts - pathology | Receptor, Angiotensin, Type 2 - genetics | Kidney - drug effects | Cells, Cultured | Rats | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Myofibroblasts - drug effects | Rats, Sprague-Dawley | Disease Progression | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | MAP Kinase Signaling System - drug effects | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Fibrosis | Mice | Pyridines - pharmacology | Receptor, Angiotensin, Type 2 - deficiency | Receptors, G-Protein-Coupled - chemistry | Receptors, Peptide - metabolism
Journal Article
Circulation Research, ISSN 0009-7330, 07/2014, Volume 115, Issue 3, pp. 388 - 399
Journal Article
Hypertension, ISSN 0194-911X, 10/2017, Volume 70, Issue 4, pp. 831 - 838
Journal Article
Hypertension, ISSN 0194-911X, 09/2012, Volume 60, Issue 3, pp. 722 - 729
Angiotensin II type 2 (AT2) receptor stimulation has been linked to vasodilation. Yet, AT2 receptor-independent hypertension and hypotension (or no effect on... 
coronary circulation | mouse | compound 21 | receptor | rat | vasorelaxation | angiotensin II | Langendorff model | METABOLITES | STIMULATION | RELAXATION | AT receptor | MEDIATED VASODILATION | CORONARY VASCULAR BED | NATRIURESIS | AT | AT RECEPTORS | NONPEPTIDE AGONIST | PERIPHERAL VASCULAR DISEASE | VASOCONSTRICTION | Mesenteric Arteries - physiology | Tetrazoles - pharmacology | Iliac Artery - drug effects | Rats, Wistar | Calcium - metabolism | Humans | Middle Aged | Receptor, Angiotensin, Type 2 - physiology | Receptor, Angiotensin, Type 2 - drug effects | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Angiotensin II Type 2 Receptor Blockers - pharmacology | Endothelium, Vascular - physiology | Phenylephrine - pharmacology | Biphenyl Compounds - pharmacology | Adult | Calcium Ionophores - pharmacology | Female | Models, Animal | Vasodilation - physiology | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Receptor, Angiotensin, Type 2 - genetics | Coronary Vessels - drug effects | Coronary Vessels - physiology | Mice, Inbred C57BL | Rats | Thiophenes - pharmacology | Imidazoles - pharmacology | Sulfonamides - pharmacology | Iliac Artery - physiology | Mice, Knockout | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Mice | Pyridines - pharmacology | Vasodilation - drug effects | In Vitro Techniques
Journal Article
Journal Article
Journal Article
Hypertension, ISSN 0194-911X, 02/2011, Volume 57, Issue 2, pp. 308 - 313
Journal Article
Journal Article
Biochimie, ISSN 0300-9084, 12/2016, Volume 131, pp. 68 - 76
Monocyte chemoattractant protein (MCP-1) and transforming growth factor-β (TGF-β1)-markers of inflammation and fibrosis, are central to type 2 diabetic... 
Macrophage infiltration | Type 2 diabetic nephropathy | Angiotensin II receptors | Fibrosis | H2A lysine 119 monoubiquitination | METHYLATION | ACTIVATION | LOSARTAN | MCP-1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | KAPPA-B | HISTONE ACETYLATION | UBIQUITINATION | DIMETHYLATION | Receptors, Angiotensin - metabolism | Kidney - pathology | Rats, Wistar | Diabetic Nephropathies - etiology | Transforming Growth Factor beta1 - metabolism | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Promoter Regions, Genetic - genetics | Angiotensin II Type 2 Receptor Blockers - pharmacology | Kidney - metabolism | Ubiquitination - drug effects | Chemokine CCL2 - metabolism | Diabetes Mellitus, Experimental - complications | Lysine - metabolism | Diabetes Mellitus, Type 2 - complications | Macrophages - pathology | Diabetic Nephropathies - metabolism | Chemokine CCL2 - genetics | Diabetic Nephropathies - genetics | Imidazoles - pharmacology | Transforming Growth Factor beta1 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - metabolism | Animals | Benzoates - pharmacology | Benzimidazoles - pharmacology | Macrophages - drug effects | Pyridines - pharmacology | Histones - metabolism | Epigenetic inheritance | Streptozocin | Lysine | Diabetic nephropathies | Angiotensin | Bone morphogenetic proteins | Transforming growth factors | Macrophages
Journal Article
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 06/2013, Volume 43, pp. 79 - 88