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Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance... 
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | ANANDAMIDE-INDUCED VASORELAXATION | RAT | IDENTIFICATION | VASCULAR ENDOTHELIUM | CORONARY-ARTERIES | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | GPR18 | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2016, Volume 22, Issue 2, pp. 194 - 201
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2014, Volume 289, Issue 30, pp. 21082 - 21097
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 593 - 606
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer | Index Medicus
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 2004, Volume 46, Issue 1, pp. 133 - 149
Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in... 
TRPV | Pain | TRPV1 | VR1 | Ion channel | Capsaicin | pain | PROTEIN-KINASE-C | 1 VR1 | RAT | ROOT GANGLION NEURONS | INTRACELLULAR CALCIUM | IODO-RESINIFERATOXIN | SPINAL-CORD | NEUROSCIENCES | CAPSAICIN RECEPTOR | NEUROPATHIC PAIN | ACTIVATED ION-CHANNEL | ion channel | capsaicin | PHARMACOLOGY & PHARMACY | Norepinephrine - pharmacology | Aniline Compounds - metabolism | Calcium - metabolism | Capsaicin - pharmacology | Embryo, Mammalian | Humans | Anilides - chemistry | Excitatory Postsynaptic Potentials - drug effects | Kidney | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Xanthenes - metabolism | Carrier Proteins - pharmacology | Neuropeptides - pharmacology | Protein Binding - drug effects | Radioligand Assay - methods | Cinnamates - chemistry | Acids - pharmacology | Membrane Potentials - drug effects | Cell Line | Orexins | Intracellular Signaling Peptides and Proteins | Rats | Capsaicin - analogs & derivatives | Excitatory Amino Acid Agonists - pharmacology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Hot Temperature | Cinnamates - pharmacology | Receptors, Drug - chemistry | Animals | Anilides - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Receptors, Drug - antagonists & inhibitors | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 7, pp. 816 - 827
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2011, Volume 163, Issue 7, pp. 1533 - 1549
BACKGROUND AND PURPOSE Endocannabinoids have both anti‐inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the... 
monoacylglycerol lipase | peroxisome proliferator‐activated receptor‐γ | nuclear factor κ‐B | endocannabinoids | neuroinflammation | cyclooxygenase‐2 | nuclear factor κ-B | peroxisome proliferator-activated receptor-γ | cyclooxygenase-2 | CB1 CANNABINOID RECEPTORS | 2-ARACHIDONYL GLYCEROL | NUCLEAR RECEPTORS | SYNAPTIC-TRANSMISSION | MICROGLIAL CELLS | KAPPA-B | OXIDATIVE-METABOLISM | peroxisome proliferator-activated receptor-gamma | PROTECTS NEURONS | nuclear factor kappa-B | ACTIVATED-RECEPTOR-GAMMA | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Interleukin-1beta - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | NF-kappa B - metabolism | Hippocampus - drug effects | PPAR gamma - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cyclooxygenase 2 - biosynthesis | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Cyclooxygenase 2 - genetics | Prostaglandin D2 - analogs & derivatives | Synaptic Transmission - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Thiazolidinediones - pharmacology | Endocannabinoids | PPAR gamma - genetics | NF-kappa B - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - pharmacology | Cells, Cultured | Arachidonic Acids - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | PPAR gamma - agonists | Mice | Prostaglandin D2 - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Index Medicus | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article