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Journal of clinical oncology, ISSN 1527-7755, 02/2012, Volume 30, Issue 5, pp. 488 - 496
Journal Article
British journal of haematology, ISSN 0007-1048, 01/2015, Volume 168, Issue 1, pp. 69 - 81
Summary Bosutinib is an oral, dual SRC/ABL1 tyrosine kinase inhibitor for resistant/intolerant chronic myeloid leukaemia (CML). We assessed the efficacy and... 
BCR‐ABL1 | CML | tyrosine kinase inhibitor | bosutinib | chronic myeloid leukaemia | Chronic myeloid leukaemia | Tyrosine kinase inhibitor | Bosutinib | BCR-ABL1 | Life Sciences & Biomedicine | Hematology | Science & Technology | Index Medicus | Haematological Malignancy
Journal Article
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 05/2008, Volume 68, Issue 9, pp. 3421 - 3428
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 04/2015, Volume 372, Issue 18, pp. 1689 - 1699
AZD9291, an irreversible inhibitor of epidermal growth factor receptor, was associated with tumor responses in the majority of patients with advanced... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - drug therapy | Humans | Middle Aged | ErbB Receptors - genetics | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Acrylamides - pharmacokinetics | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Aniline Compounds - administration & dosage | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | ErbB Receptors - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Aniline Compounds - pharmacokinetics | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Acrylamides - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Aniline Compounds - adverse effects | Acrylamides - adverse effects | Clinical trials | Care and treatment | Usage | Diagnosis | Lung cancer, Non-small cell | Patient outcomes | Tyrosine | Appetite | Inhibitor drugs | Epidermal growth factor receptors | Lung cancer | Diarrhea | Nausea | Drug resistance | Kinases | Patients | Epidermal growth factor | Pharmacokinetics | Protein-tyrosine kinase | Index Medicus | Abridged Index Medicus
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 01/2015, Volume 14, Issue 1, pp. 111 - 119
.... The efficacy of these compounds was independent of MGMT and MMR functions. DP68-induced interstrand DNA cross-links were demonstrated with H2O2-treated cells... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Agents, Alkylating - chemical synthesis | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents, Alkylating - administration & dosage | Brain Neoplasms - metabolism | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Dacarbazine - pharmacokinetics | Glioblastoma - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Aniline Compounds - administration & dosage | DNA Damage - drug effects | Dacarbazine - administration & dosage | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Neoplasm Recurrence, Local - metabolism | Mice, Inbred C57BL | Heterocyclic Compounds, 2-Ring - administration & dosage | Antineoplastic Agents, Alkylating - pharmacokinetics | Aniline Compounds - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Brain Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | Cell Line, Tumor | Mice | Cell Cycle - drug effects | Glioblastoma - drug therapy | Heterocyclic Compounds, 2-Ring - chemical synthesis | Aniline Compounds - chemical synthesis | Drug Resistance, Neoplasm - drug effects | Index Medicus | glioblastoma | MGMT | DNA damage response | FANCD2 | ATM | Temozolomide | resistance | ATR
Journal Article
Journal Article
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1533-3450, 09/2017, Volume 28, Issue 9, pp. 2756 - 2767
Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However, glucocorticoids used as treatment contribute to the morbidity... 
Life Sciences & Biomedicine