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The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 3, pp. 1269 - 1285
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INTRAHEPATIC CHOLANGIOCARCINOMA | THIOACETAMIDE | PORCUPINE | LIVER | BILIARY | BETA-CATENIN | RAT CHOLANGIOCARCINOMA | PROGRESSION | CANCER STEM-CELLS | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 07/2016, Volume 358, Issue 1, pp. 125 - 137
Journal Article
Cancer discovery, ISSN 2159-8274, 2014, Volume 4, Issue 3, pp. 362 - 675
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2009, Volume 158, Issue 4, pp. 1153 - 1164
... of the Abl kinase and the subsequent findings that this compound displays growth inhibitory and pro‐apoptotic effects in Bcr‐Abl+ cells has revolutionized trends... 
ADME-Tox | CML | TKI | ABCB1 | Bcr-Abl | MDR | ABCG2 | ADME‐Tox | Bcr‐Abl | CHRONIC MYELOGENOUS LEUKEMIA | MULTIDRUG TRANSPORTER | DRUG-RESISTANCE | CHRONIC MYELOID-LEUKEMIA | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | HIGH-AFFINITY INTERACTION | HEMATOPOIETIC STEM-CELLS | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Thiazoles - metabolism | Nitriles - pharmacology | Aniline Compounds - metabolism | Protein-Tyrosine Kinases - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Substrate Specificity | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Thiazoles - therapeutic use | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Dose-Response Relationship, Drug | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Dasatinib | Nitriles - metabolism | Aniline Compounds - pharmacology | Pyrimidines - pharmacology | Neoplasms - drug therapy | Quinolines - metabolism | Pyrimidines - therapeutic use | K562 Cells | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Thiazoles - pharmacology | Aniline Compounds - therapeutic use | Fusion Proteins, bcr-abl - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Nitriles - therapeutic use | Index Medicus | Research Papers
Journal Article
Blood, ISSN 0006-4971, 04/2008, Volume 111, Issue 7, pp. 3742 - 3750
Acute myeloid leukemia (AML) cells are relatively resistant to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL). We previously reported... 
CANCER-CELLS | DEATH RECEPTORS | IN-VITRO | LIGAND (TRAIL)-INDUCED APOPTOSIS | PROTEIN EXPRESSION | KILLER/DR5 GENE | SMALL-MOLECULE ANTAGONISTS | PROGNOSTIC-SIGNIFICANCE | LEUKEMIA CELLS | HEMATOLOGY | P53 | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents, Alkylating - pharmacology | Male | Antineoplastic Agents, Alkylating - agonists | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Epoxy Compounds - agonists | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Epoxy Compounds - pharmacology | TNF-Related Apoptosis-Inducing Ligand - pharmacology | TNF-Related Apoptosis-Inducing Ligand - agonists | U937 Cells | Diterpenes - agonists | Leukemia, Myeloid, Acute - drug therapy | Female | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Diterpenes - pharmacology | Epoxy Compounds - therapeutic use | Diterpenes - therapeutic use | Phenanthrenes - therapeutic use | Aniline Compounds - pharmacology | Phenanthrenes - agonists | Tumor Suppressor Protein p53 - metabolism | Piperazines - agonists | Aniline Compounds - agonists | Imidazoles - pharmacology | Piperazines - pharmacology | Antineoplastic Agents, Alkylating - therapeutic use | Drug Synergism | Phenanthrenes - pharmacology | Signal Transduction - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Aniline Compounds - therapeutic use | Imidazoles - agonists | Index Medicus | Abridged Index Medicus | Neoplasia
Journal Article
Cancer discovery, ISSN 2159-8290, 2014, Volume 4, Issue 9, pp. 1046 - 1061
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2006, Volume 66, Issue 17, pp. 8731 - 8739
Journal Article
The FEBS journal, ISSN 1742-464X, 2017, Volume 284, Issue 24, pp. 4177 - 4195
The ERK1/2 signalling pathway is best known for its role in connecting activated growth factor receptors to changes in gene expression due to activated ERK1/2... 
BH3‐only proteins | ERK1/2 | MEK1/2 | RAS | mitochondria | BIM | BCL2 | apoptosis | BRAF | DRP1 | BH3-only proteins | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | BH3-ONLY PROTEIN | REGULATED KINASE | BAD PHOSPHORYLATION | INHIBITS APOPTOSIS | ERK1/2-DEPENDENT PHOSPHORYLATION | MEDIATED ACTIVATION | HUMAN-MELANOMA CELLS | ERK2 PHOSPHORYLATION | MEMBRANE PERMEABILIZATION | MAP Kinase Signaling System - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Indoles - administration & dosage | Mitochondrial Dynamics - physiology | Pyrroles - administration & dosage | Indoles - pharmacology | Oncogene Addiction | Pyrroles - therapeutic use | Aniline Compounds - administration & dosage | Aniline Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Sulfonamides - pharmacology | Neoplasms - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Pyrroles - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Mitochondrial Dynamics - drug effects | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Apoptosis Regulatory Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - physiology | Indoles - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aniline Compounds - therapeutic use | Apoptosis - physiology | Neoplasms - pathology | Sulfonamides - administration & dosage | Drug Screening Assays, Antitumor | Cell death | Utrophin | Stem cells | Physiological aspects | Biochemistry | DNA binding proteins | Gene expression | Transcription factors | Decisions | Kinases | Nuclei | Fission | Proteins | Signal transduction | Mitochondria | Receptors | Bcl-x protein | Cell fate | Tumorigenesis | Repressing | Starvation | Cell survival | Extracellular signal-regulated kinase | MAP kinase | Growth factor receptors | Organelles | Survival | Substrates | Mcl-1 protein | Golgi apparatus | Signaling | Proteomics | Endoplasmic reticulum | BIM protein | Phagocytosis | Endosomes | Cancer | Apoptosis | State‐of‐the‐Art Review | ERK1 | MEK1
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets. Using small cell lung cancer (SCLC) as a model, we... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | BAK ACTIVATION | POTENT | MULTIDISCIPLINARY SCIENCES | BIM | TRANSCRIPTION | DEATH | CDK INHIBITOR | ABT-263 | BH3 DOMAIN | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis
Journal Article