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Chemical Research in Toxicology, ISSN 0893-228X, 09/2015, Volume 28, Issue 9, pp. 1760 - 1773
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2012, Volume 32, Issue 12, pp. 4004 - 4016
Previous studies have shown that modulation of the receptor-mediated cannabinoid system during neuroinflammation can produce potent neuroprotective and... 
SYNTHASE | SYSTEM | CB2 RECEPTORS | ADHESION | MULTIPLE-SCLEROSIS | EMERGING ROLE | NEUROINFLAMMATION | TRANSENDOTHELIAL MIGRATION | PATHOLOGICAL CONDITIONS | EXPRESSION | NEUROSCIENCES | Capillary Permeability - physiology | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Anisoles - pharmacology | Humans | Blood-Brain Barrier - physiopathology | Bornanes - pharmacology | Capillary Permeability - drug effects | Fluorescein-5-isothiocyanate - metabolism | Leukocytes - physiology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Phosphoproteins - metabolism | Lipopolysaccharides - adverse effects | Flow Cytometry | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Statistics, Nonparametric | Membrane Proteins - metabolism | Endothelial Cells - physiology | Disease Models, Animal | Pyrazoles - pharmacology | Dextrans - metabolism | Cell Adhesion - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Encephalitis - pathology | Fluorescein-5-isothiocyanate - analogs & derivatives | Electric Impedance | Cell Adhesion - drug effects | Blood-Brain Barrier - drug effects | Cannabinoids - pharmacology | Mice, Knockout | Gene Expression Regulation - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Intercellular Adhesion Molecule-1 - metabolism | Animals | Zonula Occludens-1 Protein | Endothelium - metabolism | Anisoles - therapeutic use | Mice | Encephalitis - chemically induced | Vascular Cell Adhesion Molecule-1 - metabolism | Receptor, Cannabinoid, CB2 - deficiency
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137515
The heart hosts tissue resident macrophages which are capable of modulating cardiac inflammation and function by multiple mechanisms. At present, the... 
GW2580 | REPAIR | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MONOCYTE SUBSETS | RUPTURE | INJURY | IMPROVES | MICE | POLARIZATION | Mannose-Binding Lectins - metabolism | Myocardial Infarction - genetics | Anisoles - pharmacology | Arginase - metabolism | Male | Interleukin-1beta - genetics | Lectins, C-Type - genetics | Lectins, C-Type - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Interleukin-1beta - metabolism | Myocardial Infarction - pathology | Myocardium - metabolism | Myocardial Infarction - physiopathology | Interleukin-6 - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Interleukin-6 - genetics | Macrophages - pathology | Signal Transduction | Gene Expression Regulation | Receptors, Cell Surface - metabolism | Mice, Transgenic | Myocardium - pathology | Arginase - genetics | Myocardial Infarction - metabolism | Pyrimidines - pharmacology | Macrophages - metabolism | Animals | Mannose-Binding Lectins - genetics | Myocardial Infarction - drug therapy | Mice | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, Cell Surface - genetics | Heart | Myocardial infarction | Heart attacks | Laboratories | Biology | Kinases | Macrophages | Interleukin 6 | Genotype & phenotype | Inhibition | Heart diseases | Enlargement | Spleen | Heart failure | Preservation | Neutrophils | Contractility | Oral administration | Macrophage colony-stimulating factor | Leukocytes (neutrophilic) | Inflammation | Gene expression | Muscle contraction | Signaling | Ostomy | Monocytes | Depletion | Collagen | Ligands | Infiltration | Infarction | Ventricle | Veins & arteries
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2017, Volume 336, pp. 75 - 83
Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy,... 
Cell proliferation | DNA adduct | PP2A | Gene mutation | Estragole | KINASE PATHWAY | HUMAN BREAST | TYROSINE PHOSPHORYLATION | CANCER CELLS | CIP2A | INACTIVATION | LUNG-CANCER | GROWTH | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Phosphorylation | Apoptosis - drug effects | Rats, Inbred F344 | Liver Neoplasms - chemically induced | Hepatocytes - pathology | Male | Cell Transformation, Neoplastic - chemically induced | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | DNA Adducts - metabolism | Dose-Response Relationship, Drug | Time Factors | Cell Transformation, Neoplastic - genetics | src-Family Kinases - metabolism | Liver Neoplasms - pathology | Liver Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Hepatocytes - drug effects | Rad51 Recombinase - metabolism | Liver Neoplasms - genetics | Rats, Transgenic | Tumor Suppressor Protein p53 - metabolism | MAP Kinase Kinase Kinases - metabolism | Cell Transformation, Neoplastic - metabolism | Animals | Anisoles - toxicity | Signal Transduction - drug effects | Protein Phosphatase 2 - metabolism | Cell Proliferation - drug effects | DNA Adducts - genetics | Histones - metabolism | Mutation | Cell Transformation, Neoplastic - pathology | Hepatocytes - enzymology | Prevention | Immunohistochemistry | Phosphatases | Gene mutations | Cellular signal transduction | Cell differentiation | Mass spectrometry | Carcinogenesis | Cancer | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2014, Volume 351, Issue 1, pp. 44 - 53
Journal Article
The Plant Journal, ISSN 0960-7412, 07/2017, Volume 91, Issue 2, pp. 292 - 305
Fruit accumulate a diverse set of volatiles including esters and phenylpropenes. Volatile esters are synthesised via fatty acid degradation or from amino acid... 
apple | phenylpropene | ester | fruit | alcohol acyl transferase | Malus domestica | volatile | CLARKIA-BREWERI | SOLID-PHASE MICROEXTRACTION | FUNCTIONAL-CHARACTERIZATION | PLANT SCIENCES | MALUS X DOMESTICA | BIOSYNTHESIS | ROYAL-GALA | GENE FAMILY | CHROMATOGRAPHY-MASS SPECTROMETRY | ALCOHOL ACYL-TRANSFERASE | FLAVOR | Volatile Organic Compounds - metabolism | Tobacco - metabolism | Anisoles - metabolism | Esters - metabolism | Phenols - metabolism | Acyltransferases - metabolism | Gene Knockout Techniques | Acyltransferases - genetics | Malus - genetics | Proteins - genetics | Fruit - growth & development | Plant Proteins - genetics | Malus - metabolism | Proteins - metabolism | Metabolic Networks and Pathways | Plants, Genetically Modified | Fragaria - genetics | Gene Expression Regulation, Plant | Lycopersicon esculentum - genetics | Plant Proteins - metabolism | Quantitative Trait Loci | Fruit - metabolism | Fruit - genetics | Quantitative genetics | Cladistic analysis | Transferases | Analysis | Amino acids | Esters | Genetic engineering | Acetates | Fatty acids | Methyltransferase | Transgenic | Alcohol | Gene expression | Volatiles | Eugenol | Substrates | Alcohols | Fruits | Chalcone synthase | Degradation | Quantitative trait loci | Ripening | Tobacco | Overexpression | Pathways | Tomatoes | Acetic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54302
Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced... 
BREAST-CANCER | INFLAMMATORY MONOCYTES | CELLS | ACTIVATION | MAMMARY-TUMORS | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | MOUSE MODEL | PAPILLARY | EXPRESSION | CCR2 | Receptors, CCR2 - genetics | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Carcinoma, Papillary - genetics | Anisoles - pharmacology | Humans | Carcinoma, Papillary - metabolism | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Chemokine CCL2 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | Macrophage Colony-Stimulating Factor - genetics | Proto-Oncogene Proteins B-raf - metabolism | Carcinoma - drug therapy | Macrophages - pathology | Carcinoma, Papillary - drug therapy | Receptor, Macrophage Colony-Stimulating Factor - genetics | Chemokine CCL2 - genetics | Mice, Transgenic | Macrophage Colony-Stimulating Factor - metabolism | Pyrimidines - pharmacology | Carcinoma, Papillary - pathology | Disease Progression | Thyroid Cancer, Papillary | Cell Movement - drug effects | Thyroid Neoplasms - genetics | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Signal Transduction - drug effects | Thyroid Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Macrophages - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Carcinoma - metabolism | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Care and treatment | Thyroid cancer | Prognosis | Analysis | Development and progression | Macrophages | Tumors | Cancer | Chemotactic factors | CC chemokine receptors | Animal models | Papillary thyroid cancer | Pathogenesis | Oncology | Recruitment | Angiogenesis | Immunology | CCR2 protein | Rodents | Tumorigenesis | Thyroid | Macrophage colony-stimulating factor | Pharmacology | Breast cancer | Medicine | Infectious diseases | Mutation | Chemokines | Monocyte chemoattractant protein 1
Journal Article
Journal Article
by Hong, J and Sha, S and Zhou, L and Wang, C and Yin, J and Chen, L
Cell Death and Disease, ISSN 2041-4889, 07/2015, Volume 6, Issue 7, pp. e1832 - e1832
Sigma-1 receptor (sigma R-1) has been reported to be decreased in nigrostriatal motor system of Parkinson's disease patients. Using heterozygous and homozygous... 
ANTAGONIST | TYROSINE PHOSPHORYLATION | MOUSE MODEL | DISEASE | DEPRESSIVE-LIKE | MITOCHONDRIAL DYSFUNCTION | DENTATE GYRUS | KNOCKOUT MICE | SUBSTANTIA-NIGRA | NEUROTOXICITY | CELL BIOLOGY | Dopamine Plasma Membrane Transport Proteins - metabolism | Microglia - metabolism | Phosphorylation | Vesicular Monoamine Transport Proteins - metabolism | Dopaminergic Neurons - pathology | Anisoles - pharmacology | Humans | Astrocytes - pathology | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Receptors, sigma - antagonists & inhibitors | Pars Compacta - pathology | Receptors, N-Methyl-D-Aspartate - genetics | Neuroprotective Agents - pharmacology | Cell Death - genetics | Piperidines - pharmacology | Dopaminergic Neurons - metabolism | Parkinson Disease, Secondary - drug therapy | Microglia - pathology | Parkinson Disease, Secondary - metabolism | Parkinson Disease, Secondary - chemically induced | Receptors, sigma - metabolism | Dopamine - metabolism | Disease Models, Animal | Phenols - pharmacology | Psychomotor Performance | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Morpholines - pharmacology | Pars Compacta - metabolism | Receptors, sigma - agonists | Receptors, sigma - genetics | Dopamine Plasma Membrane Transport Proteins - genetics | Mice, Knockout | Animals | Parkinson Disease, Secondary - genetics | Vesicular Monoamine Transport Proteins - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Mice | Propylamines - pharmacology | Astrocytes - metabolism | Original
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2017, Volume 591, Issue 20, pp. 3391 - 3401
Shewanella oneidensis , a Gram‐negative γ‐proteobacterium with an extensive redox capacity, possesses four old yellow enzyme ( OYE ) homologs. Of these,... 
old yellow enzyme | atomic resolution crystallography | cellular detoxification | oxidative stress | redox chemistry | ACID | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | HOMOLOG | FAMILY | CELL BIOLOGY | YQJM | BIOPHYSICS | SUBSTRATE | SEQUENCE | PENTAERYTHRITOL TETRANITRATE REDUCTASE | NADPH Dehydrogenase - metabolism | Oxidative Stress | Bacterial Proteins - chemistry | Substrate Specificity | Crystallography, X-Ray | NADPH Dehydrogenase - genetics | Isoenzymes - chemistry | Isoenzymes - metabolism | NADPH Dehydrogenase - chemistry | Picrates - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Gene Expression | Benzaldehydes - chemistry | Oxidation-Reduction | Protein Structure, Secondary | Isoenzymes - genetics | Picrates - metabolism | Bacterial Proteins - genetics | Shewanella - enzymology | Models, Molecular | Recombinant Proteins - chemistry | Anisoles - metabolism | Anisoles - chemistry | Recombinant Proteins - genetics | Cresols - chemistry | Cresols - metabolism | Amino Acid Motifs | Benzaldehydes - metabolism | Escherichia coli - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Bacterial Proteins - metabolism | Ligands | Kinetics | Shewanella - chemistry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 50, pp. 41439 - 41448
Cell migration is a prerequisite for cancer invasion and metastasis, suggesting cell motility as a potential therapeutic target for cancer treatment. A... 
BREAST-CANCER | ADHESION | CHEMICAL GENETICS | METASTASIS | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | KINASE-C | EXPRESSION | MASS-SPECTROMETRY | HEAT-SHOCK-PROTEIN | Neoplasms - metabolism | Phosphorylation | Models, Chemical | Anisoles - pharmacology | Bromides - chemistry | Humans | Molecular Sequence Data | Heat-Shock Proteins - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Crk-Associated Substrate Protein - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Dose-Response Relationship, Drug | RNA, Small Interfering - chemistry | Transfection | Time Factors | Protein Kinase C - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Membrane - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Neoplasm Invasiveness | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Anisoles - chemistry | Isoxazoles - chemistry | Blotting, Western | Neoplasms - drug therapy | Isoxazoles - pharmacology | Chromatography, Affinity | Cell Line, Tumor | Protein Binding | Enzyme Activation | HSP27 Heat-Shock Proteins | DNA, Complementary - metabolism | Cell Movement | Drug Screening Assays, Antitumor | RNA, Small Interfering - metabolism
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 01/2016, Volume 87, pp. 103 - 112
Journal Article