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1. Full Text Cardiac Ankyrin Repeat Protein Gene ( ANKRD1 ) Mutations in Hypertrophic Cardiomyopathy
by Arimura, Takuro, DVM, PhD and Bos, J. Martijn, MD and Sato, Akinori, MD and Kubo, Toru, MD, PhD and Okamoto, Hiroshi, MD, PhD and Nishi, Hirofumi, MD, PhD and Harada, Haruhito, MD, PhD and Koga, Yoshinori, MD, PhD and Moulik, Mousumi, MD and Doi, Yoshinori L., MD, PhD and Towbin, Jeffrey A., MD and Ackerman, Michael J., MD, PhD and Kimura, Akinori, MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 54, Issue 4, pp. 334 - 342
Objectives The purpose of this study was to explore a novel disease gene for hypertrophic cardiomyopathy (HCM) and to evaluate functional alterations caused by... 
Cardiovascular | Internal Medicine | mutation | hypertrophic cardiomyopathy | Z-disc | cardiac ankyrin repeat protein | titin/connectin | CARDIAC & CARDIOVASCULAR SYSTEMS | CARP | TITIN | DISEASE | DILATED CARDIOMYOPATHY | EXPRESSION | Cardiomyopathy, Hypertrophic - genetics | Genetic Predisposition to Disease | Humans | Middle Aged | Rats | Repressor Proteins - genetics | Male | Mutation, Missense | Muscle Proteins - genetics | Animals | Aged, 80 and over | Adult | Female | Aged | Nuclear Proteins - genetics | Polymerase chain reaction | Viral antibodies | Cardiomyopathy, Hypertrophic | Genetic research | Antibodies | Genetic aspects | Nucleic acids | Cardiology | Medical colleges | Genes | Research institutes | Cardiovascular agents | Heart | Heart attacks | Pathogenesis | Cardiomyopathy | Cloning | Cardiovascular disease | Cardiomyocytes | Family medical history | Gene expression | Proteins | Studies | Mutagenesis | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
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2. Full Text Designed ankyrin repeat proteins (DARPins): From research to therapy
by Tamaskovic, Rastislav and Simon, Manuel and Stefan, Nikolas and Schwill, Martin and Plückthun, Andreas
Methods in Enzymology, ISSN 0076-6879, 2012, Volume 503, pp. 101 - 134
Designed ankyrin repeat proteins (DARPins) have been developed into a robust and versatile scaffold for binding proteins. High-affinity binders are routinely... 
PEG, affinity determination, association rates on cells, dissociation rates on cells, fluorescence labeling, repeat proteins, tumor targeting, viral retargeting | Keywords | Click chemistry | DARPins | RECOMBINANT PROTEINS | FUNCTIONAL PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMBINATORIAL LIBRARIES | BIOCHEMICAL RESEARCH METHODS | IN-VITRO SELECTION | RIBOSOME DISPLAY | SINGLE-CHAIN FV | PHAGE DISPLAY | UNNATURAL AMINO-ACIDS | ANTITUMOR-ACTIVITY | CELL ADHESION MOLECULE | Recombinant Fusion Proteins - isolation & purification | Protein Engineering - methods | Humans | Molecular Sequence Data | Polyethylene Glycols - chemistry | Peptide Library | Proteins - therapeutic use | Thermodynamics | Drug Design | Biomedical Research | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Protein Stability | Amino Acid Sequence | Fluorescent Dyes - chemistry | Genetic Vectors - chemistry | Affinity Labels - chemistry | Click Chemistry | Ribosomes - chemistry | Ankyrin Repeat | Recombinant Fusion Proteins - chemistry | Escherichia coli - chemistry | Animals | Viruses - chemistry | Protein Binding | Titrimetry | Proteins - chemistry | Index Medicus
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3. Full Text Nanospring behaviour of ankyrin repeats
by Bennett, Vann and Jiang, Yong and Marszalek, Piotr E and Lee, Gwangrog and Michaely, Peter and Abdi, Khadar
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7081, pp. 246 - 249
Ankyrin repeats are an amino-acid motif believed to function in protein recognition; they are present in tandem copies in diverse proteins in nearly all phyla.... 
SINGLE PROTEIN | HAIR-CELL | SPECTROSCOPY | SPECTRIN | CHANNEL | MOLECULE | TITIN | MULTIDISCIPLINARY SCIENCES | AFM | HEARING | ATOMIC-FORCE MICROSCOPE | Protein Structure, Tertiary | Nanostructures - ultrastructure | Transient Receptor Potential Channels - chemistry | Elasticity | Structure-Activity Relationship | Protein Folding | Amino Acid Motifs | Ankyrins - chemistry | Repetitive Sequences, Amino Acid | Animals | Ankyrins - metabolism | Ankyrins - ultrastructure | Microscopy, Atomic Force | Nanostructures - chemistry | Mechanoreceptors - chemistry | Mechanoreceptors - metabolism | Nanotechnology | Protein Renaturation | Biotechnology | Amino acids | Index Medicus
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4. Full Text Designing Repeat Proteins: Well-expressed, Soluble and Stable Proteins from Combinatorial Libraries of Consensus Ankyrin Repeat Proteins
by Binz, H.Kaspar and Stumpp, Michael T and Forrer, Patrik and Amstutz, Patrick and Plückthun, Andreas
Journal of Molecular Biology, ISSN 0022-2836, 2003, Volume 332, Issue 2, pp. 489 - 503
We describe an efficient way to generate combinatorial libraries of stable, soluble and well-expressed ankyrin repeat (AR) proteins. Using a combination of... 
scaffold | protein design | ankyrin repeat | consensus sequence | combinatorial library | Scaffold | Consensus sequence | Protein design | Combinatorial library | Ankyrin repeat | DOMAIN | CRYSTAL-STRUCTURE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA | DISPLAY | KAPPA-B COMPLEX | MUTATIONS | SELECTION | MELANOGASTER NOTCH RECEPTOR | MYOTROPHIN | Consensus Sequence | Protein Structure, Tertiary | Amino Acid Sequence | Temperature | Gene Library | Models, Molecular | Molecular Sequence Data | Ankyrin Repeat | Repetitive Sequences, Amino Acid | Base Sequence | Databases, Protein | Protein Engineering | Circular Dichroism | Index Medicus
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5. Full Text Mutations in the 5′ UTR of ANKRD26, the Ankirin Repeat Domain 26 Gene, Cause an Autosomal-Dominant Form of Inherited Thrombocytopenia, THC2
by Pippucci, Tommaso and Savoia, Anna and Perrotta, Silverio and Pujol-Moix, Núria and Noris, Patrizia and Castegnaro, Giovanni and Pecci, Alessandro and Gnan, Chiara and Punzo, Francesca and Marconi, Caterina and Gherardi, Samuele and Loffredo, Giuseppe and De Rocco, Daniela and Scianguetta, Saverio and Barozzi, Serena and Magini, Pamela and Bozzi, Valeria and Dezzani, Luca and Di Stazio, Mariateresa and Ferraro, Marcella and Perini, Giovanni and Seri, Marco and Balduini, Carlo L
The American Journal of Human Genetics, ISSN 0002-9297, 01/2011, Volume 88, Issue 1, pp. 115 - 120
THC2, an autosomal-dominant thrombocytopenia described so far in only two families, has been ascribed to mutations in or . Here, we show that another gene... 
MAPS | MATURATION | PROTEINS | EXPRESSION | GENETICS & HEREDITY | Conserved Sequence - genetics | Humans | Thrombocytopenia - congenital | Molecular Sequence Data | Male | Genetic Loci | Haploinsufficiency | Thrombocytopenia - genetics | Ankyrin Repeat - genetics | Genes, Dominant | Pedigree | Base Sequence | Female | Mutation | Chromosome Breakage | Chromosome Disorders - genetics | Thrombocytopenia | Gene mutations | Causes of | Genetic aspects | Research | Binding proteins | Structure | Apoptosis | Protein binding | Gene loci | Genomes | Blood platelets | Blood diseases | Genes | Index Medicus | Report
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6. Full Text Ankyrin‐repeat proteins from sponge symbionts modulate amoebal phagocytosis
by Nguyen, Mary T. H. D and Liu, Michael and Thomas, Torsten
Molecular Ecology, ISSN 0962-1083, 03/2014, Volume 23, Issue 6, pp. 1635 - 1645
Bacteria–eukaryote symbiosis occurs in all stages of evolution, from simple amoebae to mammals, and from facultative to obligate associations. Sponges are... 
eukaryotic‐like proteins | ymbastela concentrica | symbiont evolution | phagosome development | horizontal gene transfer | symbiosis | eukaryotic-like proteins | Cymbastela concentrica | CELLS | LEGIONELLA-PNEUMOPHILA | BACTERIA | SEQUENCE DATA | HUMAN MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MARINE SPONGES | EVOLUTIONARY BIOLOGY | GENE-EXPRESSION | ECOLOGY | DIVERSITY | ELECTRON-MICROSCOPE | REVEALS | Symbiosis | Vacuoles - physiology | Bacterial Proteins - genetics | Molecular Sequence Data | Phagosomes - physiology | Gammaproteobacteria - physiology | Ankyrin Repeat | Phylogeny | Acanthamoeba - physiology | Animals | Bacterial Proteins - metabolism | Gammaproteobacteria - genetics | Porifera - microbiology | Phagocytosis | Fluorescence | Enzymes | Bacteria | Nutrition | Genomics | Requirements | Proteins | Eukaryotes | Cellular biology | Index Medicus
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7. Full Text A General Computational Approach for Repeat Protein Design
by Parmeggiani, Fabio and Huang, Po-Ssu and Vorobiev, Sergey and Xiao, Rong and Park, Keunwan and Caprari, Silvia and Su, Min and Seetharaman, Jayaraman and Mao, Lei and Janjua, Haleema and Montelione, Gaetano T and Hunt, John and Baker, David
Journal of Molecular Biology, ISSN 0022-2836, 01/2015, Volume 427, Issue 2, pp. 563 - 575
Repeat proteins have considerable potential for use as modular binding reagents or biomaterials in biomedical and nanotechnology applications. Here we describe... 
de novo design | computational design | thermodynamic stability | repeat proteins | idealized proteins | Idealized proteins | Repeat proteins | Thermodynamic stability | De novo design | Computational design | DOMAIN | RECOGNITION | PEPTIDE-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONSENSUS DESIGN | TPR MOTIF | MOLECULAR-REPLACEMENT | DATABASE | DATA-BANK | SEQUENCE | SMART | Amino Acid Sequence | Microfilament Proteins - chemistry | Protein Engineering - methods | Biocompatible Materials - chemistry | Armadillo Domain Proteins - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Armadillo Domain Proteins - genetics | Ankyrins - chemistry | Proteins - genetics | Sequence Analysis, Protein | Sequence Alignment | Ankyrins - genetics | Computer Simulation | Protein Conformation | Molecular Structure | Proteins - chemistry | Microfilament Proteins - genetics | Proteins | Family | Biological products | Analysis | Nanotechnology | Index Medicus
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8. Full Text Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase
by Lemonidis, Kimon and MacLeod, Ruth and Baillie, George S and Chamberlain, Luke H
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 42, pp. 17190 - 17202
zDHHC S-acyltransferases are enzymes catalyzing protein S-acylation, a common post-translational modification on proteins frequently affecting their membrane... 
CELLS | MEMBRANE SUPPORTS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PALMITOYL ACYLTRANSFERASE | HIP14 | MICE | DIFFERENTIATION | MAP KINASE ACTIVATION | HUNTINGTONS-DISEASE | SUBSTRATE RECOGNITION | Adaptor Proteins, Signal Transducing - chemistry | Cell Line | HSP40 Heat-Shock Proteins - metabolism | Peptides - chemistry | Humans | Ankyrin Repeat | Synaptosomal-Associated Protein 25 - chemistry | Acyltransferases - metabolism | Proteome - chemistry | Protein Array Analysis - methods | Nerve Tissue Proteins - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Membrane Proteins - chemistry | Protein Binding | Acyltransferases - chemistry | Membrane Proteins - metabolism | Synaptosomal-Associated Protein 25 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | HSP40 Heat-Shock Proteins - chemistry | Proteome - metabolism | Index Medicus | enzyme | zDHHC13 | cytoskeleton | zDABM | zDHHC17 | ankyrin-repeat domain | peptide array | protein-protein interaction | Cell Biology | protein palmitoylation
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9. Full Text Vaccinia virus K1 ankyrin repeat protein inhibits NF-κB activation by preventing RelA acetylation
by Bravo Cruz, Ariana G and Shisler, Joanna L
Journal of General Virology, ISSN 0022-1317, 10/2016, Volume 97, Issue 10, pp. 2691 - 2702
The vaccinia virus (VACV) K1 protein inhibits dsRNA-dependent protein kinase (PKR) activation. A consequence of this function is that K1 inhibits PKR-induced... 
NF-κB | Ankyrin | Poxvirus | Vaccinia | RelA | KINASE COMPLEX | DELETION MUTANT | VIROLOGY | TRANSCRIPTIONAL COACTIVATORS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PKR | POXVIRUS | SIGNAL-INDUCED DEGRADATION | F-BOX PROTEINS | VIRULENCE FACTOR | ALPHA | HOST-RANGE PROTEIN | Vaccinia - virology | Signal Transduction | Vaccinia virus - metabolism | Viral Proteins - chemistry | Humans | Viral Proteins - genetics | NF-kappa B - metabolism | Ankyrin Repeat | Transcription Factor RelA - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Vaccinia - genetics | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Protein Binding | Acetylation | Vaccinia - metabolism | Index Medicus
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10. Full Text High-affinity binders selected from designed ankyrin repeat protein libraries
by Kohl, Andreas and Forrer, Patrik and Briand, Christophe and Stumpp, Michael T and Binz, H Kaspar and Amstutz, Patrick and Grütter, Markus G and Plückthun, Andreas
Nature Biotechnology, ISSN 1087-0156, 05/2004, Volume 22, Issue 5, pp. 575 - 582
We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity target binding. Using a consensus design strategy, we... 
ANTIBODIES | EVOLUTION | RECOGNITION | STRUCTURAL BASIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RIBOSOME DISPLAY | DIVERSITY | SCAFFOLDS | BINDING-SITES | AFFIBODY | PROGRAM | Molecular Sequence Data | Amino Acid Sequence | Protein Conformation | Ankyrin Repeat | Enzyme-Linked Immunosorbent Assay | Index Medicus
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11. Full Text Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
by Simeon, R and Jiang, MQ and Chamoun-Emanuelli, AM and Yu, H and Zhang, YR and Meng, R and Peng, ZY and Jakana, J and Zhang, JJ and Feng, HP and Chen, ZL
PLOS BIOLOGY, ISSN 1544-9173, 06/2019, Volume 17, Issue 6, pp. e3000311 - e3000311
Clostridium difficile infection (CDI) is a major nosocomial disease associated with significant morbidity and mortality. The pathology of CDI stems primarily... 
FRIZZLED PROTEINS | BEZLOTOXUMAB | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMBINATORIAL LIBRARIES | BIOLOGY | BINDING DOMAIN | DARPINS | RECEPTOR | INFECTION | TCDB | CLOSTRIDIUM-DIFFICILE | PHAGE | Nosocomial infection | Visualization | Regulatory agencies | Toxin A | Oligopeptides | Authorship | Epithelial cells | Pathogenesis | Funding | Frizzled protein | Biochemistry | Drug development | pH effects | Proteins | Receptors | Immunology | Stains | Supervision | Enzyme-linked immunosorbent assay | Pathogens | Proteoglycans | Medical imaging | Tight junctions | Toxin b | Crops | FDA approval | Biophysics | Bends | Electron microscopy | Morbidity | Pathogenicity | Transmission electron microscopy | Hospitals | Exotoxins | Antibiotics | Microscopy | Monoclonal antibodies | In vivo methods and tests | Chondroitin sulfate | Toxins | Dimers | Ankyrin | Protein structure | Methods | Neutralization
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12. Full Text Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen–deuterium exchange mass spectrometry (HDX‐MS)
by Ramsey, Kristen M and Narang, Dominic and Komives, Elizabeth A
Protein Science, ISSN 0961-8368, 09/2018, Volume 27, Issue 9, pp. 1624 - 1635
The ankyrin repeat (AR) structure is a common protein–protein interaction motif and ankyrin repeat proteins comprise a vast family across a large array of... 
amide exchange | structure prediction | repeat protein | homology model | Deuterium Exchange Measurement | Humans | Mass Spectrometry | Models, Molecular | I-kappa B Proteins - chemistry | Protein Conformation | Ankyrin Repeat | Proto-Oncogene Proteins - chemistry | Deuterium | Exchanging | Spectroscopy | Structural members | Homology | Mass spectroscopy | Augmented reality | Proteins | Domains | Modelling | Scientific imaging | Ankyrin | Mass spectrometry | Protein structure | Hydrogen ion concentration | Crystal structure | Index Medicus | Full‐Length Papers | Full‐Length Paper
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13. Full Text Probing Muscle Ankyrin‐Repeat Protein (MARP) Structure and Function
by Lun, Alexander Shiang and Chen, Ju and Lange, Stephan
The Anatomical Record, ISSN 1932-8486, 09/2014, Volume 297, Issue 9, pp. 1615 - 1629
Muscle ankyrin‐repeat proteins (MARPs) have been shown to serve diverse functions within cardiac and skeletal muscle cells. Apart from their interactions with... 
titin | MARP | kinase | phosphorylation | muscle | Phosphorylation | Muscle | Kinase | Titin | ANKRD1 MUTATIONS | CARP | ANATOMY & MORPHOLOGY | CARDIAC TITIN | DILATED CARDIOMYOPATHY | COILED-COILS | SKELETAL-MUSCLE | HEART DEVELOPMENT | SUBSTRATE |