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Journal Article
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2014, Volume 50, Issue 5, pp. 876 - 884
Abstract Background LY2584702 tosylate (hereafter referred to as LY2584702) is an oral, selective ATP competitive inhibitor of p70 S6 kinase. Preclinical... 
Hematology, Oncology and Palliative Medicine | p70 S6 kinase inhibitor | LY2584702 tosylate | Erlotinib | Everolimus | Life Sciences & Biomedicine | Oncology | Science & Technology | Erlotinib Hydrochloride | Neoplasms - metabolism | Area Under Curve | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Metabolic Clearance Rate | Fatigue - chemically induced | Protein Kinase Inhibitors - adverse effects | Diarrhea - chemically induced | Dose-Response Relationship, Drug | Time Factors | Adult | Female | Quinazolines - administration & dosage | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacokinetics | Sirolimus - adverse effects | Pyrazoles - adverse effects | Protein Kinase Inhibitors - pharmacokinetics | Sirolimus - analogs & derivatives | Drug Administration Schedule | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Pyrimidines - administration & dosage | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Treatment Outcome | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Sirolimus - administration & dosage | Vomiting - chemically induced | Pyrazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - adverse effects | Quinazolines - adverse effects | Pyrimidines - pharmacokinetics | Anorexia - chemically induced | Aged | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Clinical trials | Care and treatment | Product development | Tumors | Index Medicus | Life Sciences | Cancer
Journal Article
Journal of thoracic oncology, ISSN 1556-0864, 01/2013, Volume 8, Issue 1, pp. 79 - 88
Journal Article
European journal of cancer (1990), ISSN 0959-8049, 05/2017, Volume 76, pp. 144 - 151
Abstract Purpose In tumours with wild-type TP53 , the tumour-suppressive function of p53 is frequently inhibited by HDM2. This phase I, dose-escalating study... 
Hematology, Oncology and Palliative Medicine | HDM2 | De-differentiated liposarcoma | Pharmacodynamics | Solid tumours | MDM2 | Pharmacokinetics | SAR405838 | p53 | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Nausea - chemically induced | Gastrointestinal Neoplasms - drug therapy | Humans | Middle Aged | Spiro Compounds - administration & dosage | Lung Neoplasms - pathology | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Spiro Compounds - adverse effects | Indoles - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Gastrointestinal Neoplasms - pathology | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Skin Neoplasms - pathology | Liposarcoma - drug therapy | Liposarcoma - pathology | Thrombocytopenia - chemically induced | Melanoma - pathology | Spiro Compounds - pharmacokinetics | Neoplasms - drug therapy | Vomiting - chemically induced | Maximum Tolerated Dose | Indoles - adverse effects | Melanoma - drug therapy | Anorexia - chemically induced | Indoles - pharmacokinetics | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasms - pathology | Tumor proteins | Care and treatment | Tumors | Index Medicus
Journal Article
International journal of clinical oncology, ISSN 1341-9625, 2/2016, Volume 21, Issue 1, pp. 110 - 117
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 07/2011, Volume 6, Issue 7, pp. e21836 - e21836
Background: Anti-tuberculosis drug induced liver injury (ATLI) is emerging as a significant threat to tuberculosis control in China, though limited data is available about the burden of ATLI at population level... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Drug-Related Side Effects and Adverse Reactions - blood | Risk Assessment - methods | Antitubercular Agents - adverse effects | Prospective Studies | Nausea - chemically induced | Drug-Related Side Effects and Adverse Reactions - chemically induced | Humans | Middle Aged | Male | Alanine Transaminase - blood | Drug Monitoring - methods | Incidence | Risk Assessment - statistics & numerical data | Tuberculosis - drug therapy | Adult | Female | Chemical and Drug Induced Liver Injury - blood | Chemical and Drug Induced Liver Injury - etiology | Risk Factors | Chemical and Drug Induced Liver Injury - epidemiology | China - epidemiology | Drug-Related Side Effects and Adverse Reactions - epidemiology | Vomiting - chemically induced | Anorexia - chemically induced | Drug Monitoring - statistics & numerical data | Prevention | Drugs | Medical research | Liver diseases | Tuberculosis | Liver | Medicine, Experimental | Antitubercular agents | Drug therapy | Therapy | Anorexia | Science | Population studies | Epidemiology | Confidence intervals | Hepatitis | Vomiting | Hepatotoxicity | Public health | Enzymes | Task forces | Alanine | Lung diseases | Nausea | Patients | Disease control | Disease prevention | Chemotherapy | Infectious diseases | Alanine transaminase | Index Medicus
Journal Article